SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 12 LEU A  37
GLY A  59
LEU A  77
LEU A  42
LEU A  22
 None
 1.17A 3cjtG-2j8iA:
undetectable		 3cjtG-2j8iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 12 LEU A  42
GLY A  64
LEU A  82
LEU A  47
LEU A  27
 None
 1.19A 3cjtG-2j8iA:
undetectable		 3cjtG-2j8iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 10 LEU A  37
LEU A  57
ASN A  51
SER A  33
ALA A  45
 None
 1.10A 4xj7C-2j8iA:
undetectable
4xj7D-2j8iA:
undetectable		 4xj7C-2j8iA:
23.02
4xj7D-2j8iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 10 LEU A  57
LEU A  77
ASN A  71
SER A  53
ALA A  65
 None
 1.08A 4xj7C-2j8iA:
undetectable
4xj7D-2j8iA:
undetectable		 4xj7C-2j8iA:
23.02
4xj7D-2j8iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 8 LEU A  57
LEU A  67
ALA A  90
LEU A  77
ALA A  75
 None
 1.04A 4z90A-2j8iA:
undetectable
4z90B-2j8iA:
undetectable
4z90C-2j8iA:
undetectable
4z90D-2j8iA:
undetectable
4z90E-2j8iA:
undetectable		 4z90A-2j8iA:
14.33
4z90B-2j8iA:
14.33
4z90C-2j8iA:
14.33
4z90D-2j8iA:
14.33
4z90E-2j8iA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2j8i NP275
(Nostoc
punctiforme) 		6 / 9 LEU A  22
LEU A   6
LEU A  32
ALA A  35
LEU A  42
ALA A  40
 None
 1.21A 4z91F-2j8iA:
undetectable
4z91G-2j8iA:
undetectable
4z91H-2j8iA:
undetectable
4z91I-2j8iA:
undetectable
4z91J-2j8iA:
undetectable		 4z91F-2j8iA:
14.33
4z91G-2j8iA:
14.33
4z91H-2j8iA:
14.33
4z91I-2j8iA:
14.33
4z91J-2j8iA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2j8i NP275
(Nostoc
punctiforme) 		6 / 9 LEU A  32
ALA A  35
LEU A  42
ALA A  40
LEU A  22
LEU A   6
 None
 1.26A 4z91F-2j8iA:
undetectable
4z91G-2j8iA:
undetectable
4z91H-2j8iA:
undetectable
4z91I-2j8iA:
undetectable
4z91J-2j8iA:
undetectable		 4z91F-2j8iA:
14.33
4z91G-2j8iA:
14.33
4z91H-2j8iA:
14.33
4z91I-2j8iA:
14.33
4z91J-2j8iA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2j8i NP275
(Nostoc
punctiforme) 		6 / 9 LEU A  92
ALA A  75
LEU A  77
LEU A  82
LEU A  87
ALA A  90
 None
 1.12A 4z91F-2j8iA:
undetectable
4z91G-2j8iA:
undetectable
4z91H-2j8iA:
undetectable
4z91I-2j8iA:
undetectable
4z91J-2j8iA:
undetectable		 4z91F-2j8iA:
14.33
4z91G-2j8iA:
14.33
4z91H-2j8iA:
14.33
4z91I-2j8iA:
14.33
4z91J-2j8iA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 12 LEU A  82
LEU A  22
MET A   1
ILE A  30
ALA A  55
 None
 1.25A 5ienA-2j8iA:
undetectable		 5ienA-2j8iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 12 LEU A  82
MET A   1
ILE A  30
ALA A  55
LEU A  32
 None
 0.95A 5ienB-2j8iA:
undetectable		 5ienB-2j8iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 9 THR A  61
ALA A  60
ALA A  40
GLY A  64
ALA A  45
 None
 1.08A 5l5zK-2j8iA:
undetectable
5l5zL-2j8iA:
undetectable		 5l5zK-2j8iA:
21.70
5l5zL-2j8iA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 9 THR A  61
ALA A  60
ALA A  40
GLY A  64
ALA A  45
 None
 1.08A 5l5zY-2j8iA:
undetectable
5l5zZ-2j8iA:
undetectable		 5l5zY-2j8iA:
21.70
5l5zZ-2j8iA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2j8i NP275
(Nostoc
punctiforme) 		5 / 12 LEU A  47
ALA A  45
LEU A  22
ILE A  30
ALA A  50
 None
 1.01A 5xiwB-2j8iA:
undetectable		 5xiwB-2j8iA:
22.50