SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  93
ASP A  92
ASP A  60
ASP A  12
 None
 1.11A 3havA-2j8mA:
undetectable		 3havA-2j8mA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  19
ILE A  55
SER A  70
LEU A 103
 None
 0.91A 4m51A-2j8mA:
undetectable		 4m51A-2j8mA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.41A 4qvqV-2j8mA:
undetectable
4qvqb-2j8mA:
undetectable		 4qvqV-2j8mA:
21.85
4qvqb-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.41A 4qvqH-2j8mA:
undetectable
4qvqN-2j8mA:
undetectable		 4qvqH-2j8mA:
21.85
4qvqN-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.42A 4qw0V-2j8mA:
undetectable
4qw0b-2j8mA:
undetectable		 4qw0V-2j8mA:
21.85
4qw0b-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.42A 4qw0H-2j8mA:
undetectable
4qw0N-2j8mA:
undetectable		 4qw0H-2j8mA:
21.85
4qw0N-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.40A 4qw3V-2j8mA:
undetectable
4qw3b-2j8mA:
undetectable		 4qw3V-2j8mA:
21.85
4qw3b-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 118
PHE A 139
HIS A 134
GLU A  85
 None
 1.41A 5ad9A-2j8mA:
undetectable
5ad9B-2j8mA:
undetectable		 5ad9A-2j8mA:
16.39
5ad9B-2j8mA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.41A 5cz7H-2j8mA:
undetectable
5cz7N-2j8mA:
undetectable		 5cz7H-2j8mA:
21.85
5cz7N-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.42A 5d0xV-2j8mA:
undetectable
5d0xb-2j8mA:
undetectable		 5d0xV-2j8mA:
21.85
5d0xb-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  86
THR A  83
ARG A 112
GLY A 115
ALA A 111
 None
 1.41A 5d0xH-2j8mA:
undetectable
5d0xN-2j8mA:
undetectable		 5d0xH-2j8mA:
21.85
5d0xN-2j8mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 7 HIS A  86
HIS A 134
LEU A 137
SER A 130
 None
None
None
AZI  A1174 ( 3.9A)
 0.97A 5m8rA-2j8mA:
undetectable		 5m8rA-2j8mA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  86
HIS A 134
LEU A 137
SER A 130
 None
None
None
AZI  A1174 ( 3.9A)
 0.97A 5m8rB-2j8mA:
undetectable		 5m8rB-2j8mA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  86
HIS A 134
LEU A 137
SER A 130
 None
None
None
AZI  A1174 ( 3.9A)
 0.96A 5m8rD-2j8mA:
undetectable		 5m8rD-2j8mA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 158
VAL A 148
GLN A 144
HIS A 134
 None
 0.98A 5nu7A-2j8mA:
undetectable		 5nu7A-2j8mA:
19.25