SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 7 TYR A  93
VAL A 105
ILE A 118
TYR A 119
GLY A 135
 None
 1.05A 11gsA-2j8xA:
undetectable		 11gsA-2j8xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 7 TYR A  93
ILE A 118
TYR A 119
GLY A 135
 None
 0.83A 11gsB-2j8xA:
undetectable		 11gsB-2j8xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 10 TYR A  93
VAL A 105
ILE A 118
TYR A 119
GLY A 135
 None
 1.09A 13gsA-2j8xA:
undetectable		 13gsA-2j8xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 GLU A  68
ILE A  52
ARG A  57
 None
 0.70A 1cd2A-2j8xA:
undetectable		 1cd2A-2j8xA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 8 ALA A 102
LEU A  88
LEU A 238
THR A 210
 None
 0.98A 1dvtA-2j8xA:
undetectable
1dvtB-2j8xA:
undetectable		 1dvtA-2j8xA:
20.09
1dvtB-2j8xA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  50
VAL A  55
TRP A 167
 None
 0.89A 1jnoA-2j8xA:
undetectable		 1jnoA-2j8xA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  50
VAL A  55
TRP A 167
 None
 0.88A 1jnoB-2j8xA:
undetectable		 1jnoB-2j8xA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  50
VAL A  55
TRP A 167
 None
 0.92A 1ng8A-2j8xA:
undetectable		 1ng8A-2j8xA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  50
VAL A  55
TRP A 167
 None
 0.92A 1ng8B-2j8xA:
undetectable		 1ng8B-2j8xA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  50
VAL A  55
TRP A 167
 None
 0.86A 1nruA-2j8xA:
undetectable		 1nruA-2j8xA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  50
VAL A  55
TRP A 167
 None
 0.86A 1nruB-2j8xA:
undetectable		 1nruB-2j8xA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  53
VAL A  55
TRP A 167
 None
 0.88A 1nt6A-2j8xA:
undetectable		 1nt6A-2j8xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  53
VAL A  55
TRP A 167
 None
 0.89A 1nt6B-2j8xA:
undetectable		 1nt6B-2j8xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 12 LEU A 146
MET A 188
VAL A 186
HIS A 235
ILE A 118
 None
 1.34A 1z95A-2j8xA:
undetectable		 1z95A-2j8xA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 10 TYR A  93
PHE A 236
LEU A 137
LEU A 147
ILE A  87
 None
 1.06A 2bxeB-2j8xA:
undetectable		 2bxeB-2j8xA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 12 LEU A 200
ILE A 201
LEU A 148
VAL A  86
LEU A  88
 None
 1.06A 2bxfB-2j8xA:
undetectable		 2bxfB-2j8xA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 12 GLY A  96
ALA A  98
ASN A 149
PRO A 159
GLY A 160
 None
 1.00A 2vmyA-2j8xA:
undetectable		 2vmyA-2j8xA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 7 TYR A  93
VAL A 105
ILE A 118
GLY A 135
 None
 1.00A 3gssA-2j8xA:
undetectable		 3gssA-2j8xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 7 TYR A  93
VAL A 105
ILE A 118
GLY A 135
 None
 1.00A 3gssB-2j8xA:
undetectable		 3gssB-2j8xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 9 ALA A 239
VAL A 145
ILE A 118
LEU A 137
ILE A  87
 None
 1.18A 3jw3B-2j8xA:
undetectable		 3jw3B-2j8xA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
PHE A 103
SER A 114
ASN A 149
 None
 0.75A 4wryA-2j8xA:
29.4		 4wryA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
PHE A 103
SER A 114
HIS A 213
 None
 0.79A 4wryA-2j8xA:
29.4		 4wryA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
TYR A  93
PHE A 103
ASN A 149
 None
 0.96A 4wryA-2j8xA:
29.4		 4wryA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
TYR A  93
PHE A 103
HIS A 213
 None
 1.03A 4wryA-2j8xA:
29.4		 4wryA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 8 GLN A  90
PHE A 103
SER A 114
HIS A 213
 None
 0.63A 4wrzA-2j8xA:
28.8		 4wrzA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 8 GLN A  90
TYR A  93
PHE A 103
HIS A 213
 None
 0.75A 4wrzA-2j8xA:
28.8		 4wrzA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
PHE A 103
SER A 114
ASN A 149
 None
 0.76A 4wrzA-2j8xA:
28.8		 4wrzA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
TYR A  93
PHE A 103
ASN A 149
 None
 0.99A 4wrzA-2j8xA:
28.8		 4wrzA-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 7 GLY A  89
GLN A  90
TYR A  93
PHE A 103
ASN A 149
 None
 0.75A 4ws0A-2j8xA:
28.9		 4ws0A-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
PHE A 103
SER A 114
ASN A 149
 None
 0.60A 4ws1A-2j8xA:
28.9		 4ws1A-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 8 GLY A  89
GLN A  90
TYR A  93
PHE A 103
ASN A 149
 None
 0.75A 4ws1A-2j8xA:
28.9		 4ws1A-2j8xA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 8 GLY A  89
PHE A 103
SER A 114
HIS A 213
 None
 0.70A 4ws1A-2j8xA:
28.9		 4ws1A-2j8xA:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		4 / 6 VAL A 174
HIS A 173
LEU A  38
LEU A  48
 None
 1.21A 5hrqB-2j8xA:
undetectable
5hrqI-2j8xA:
undetectable
5hrqJ-2j8xA:
undetectable		 5hrqB-2j8xA:
7.17
5hrqI-2j8xA:
6.45
5hrqJ-2j8xA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 12 ASP A 252
ARG A 254
PRO A 127
GLU A 121
ASN A 234
 None
 1.24A 5il1A-2j8xA:
undetectable		 5il1A-2j8xA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2j8x URACIL-DNA
GLYCOSYLASE
(Human
gammaherpesvirus
4) 		5 / 12 ASP A 252
ARG A 254
PRO A 127
GLU A 121
ASN A 234
 None
 1.23A 5k7uA-2j8xA:
undetectable		 5k7uA-2j8xA:
21.46