SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 8 ALA A  58
ALA A 396
ILE A  65
GLU A  49
 None
 0.74A 3dtuC-2j9iA:
undetectable
3dtuD-2j9iA:
undetectable		 3dtuC-2j9iA:
20.98
3dtuD-2j9iA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		3 / 3 ILE A  88
SER A  28
SER A  30
 None
 0.57A 3iltH-2j9iA:
undetectable		 3iltH-2j9iA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 322
GLY A 229
HIS A 231
ALA A 197
LEU A 333
 None
 1.35A 3tm4A-2j9iA:
undetectable		 3tm4A-2j9iA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		5 / 12 ARG A 210
ILE A 182
ALA A  77
THR A  84
ALA A  81
 None
 1.19A 3ua1A-2j9iA:
undetectable		 3ua1A-2j9iA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		5 / 9 ALA A 273
ALA A 327
ALA A 324
SER A 230
ALA A 271
 None
 1.21A 4twdA-2j9iA:
undetectable
4twdB-2j9iA:
undetectable
4twdC-2j9iA:
undetectable
4twdD-2j9iA:
undetectable
4twdE-2j9iA:
undetectable		 4twdA-2j9iA:
18.33
4twdB-2j9iA:
18.33
4twdC-2j9iA:
18.33
4twdD-2j9iA:
18.33
4twdE-2j9iA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		5 / 9 ALA A 327
ALA A 325
SER A 230
ALA A 219
ALA A 276
 None
 1.21A 4twdA-2j9iA:
undetectable
4twdB-2j9iA:
undetectable
4twdC-2j9iA:
undetectable
4twdD-2j9iA:
undetectable
4twdE-2j9iA:
undetectable		 4twdA-2j9iA:
18.33
4twdB-2j9iA:
18.33
4twdC-2j9iA:
18.33
4twdD-2j9iA:
18.33
4twdE-2j9iA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 8 ILE A 318
GLU A 365
ALA A 266
LEU A 264
 None
 0.77A 5og9A-2j9iA:
undetectable		 5og9A-2j9iA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		3 / 3 TYR A 330
ALA A 106
LEU A 107
 None
 0.60A 6ag0C-2j9iA:
undetectable		 6ag0C-2j9iA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 4 ALA A 280
ALA A 283
ALA A 324
ALA A 326
 None
 0.61A 6gtqA-2j9iA:
0.0
6gtqB-2j9iA:
0.0		 6gtqA-2j9iA:
15.70
6gtqB-2j9iA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 4 ALA A 324
ALA A 326
ALA A 280
ALA A 283
 None
 0.62A 6gtqA-2j9iA:
0.0
6gtqB-2j9iA:
0.0		 6gtqA-2j9iA:
15.70
6gtqB-2j9iA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 ARG A 210
ALA A  77
THR A  84
ALA A  81
 None
 1.13A 6ma6A-2j9iA:
undetectable		 6ma6A-2j9iA:
9.98