SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		4 / 8 ARG A 626
GLN A 629
TYR A 617
THR A 615
 None
None
ATP  A1752 (-3.5A)
None
 1.06A 2vxaF-2j9lA:
undetectable
2vxaG-2j9lA:
undetectable
2vxaI-2j9lA:
undetectable		 2vxaF-2j9lA:
18.92
2vxaG-2j9lA:
18.92
2vxaI-2j9lA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 ILE A 722
THR A 724
ASP A 727
LYS A 730
PRO A 621
 ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
None
None
 1.04A 3kpbA-2j9lA:
12.0		 3kpbA-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 ILE A 722
THR A 724
ASP A 727
SER A 618
PRO A 621
 ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
ATP  A1752 (-3.3A)
None
 0.63A 3kpbA-2j9lA:
12.0		 3kpbA-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 ILE A 722
THR A 724
ASP A 727
LYS A 730
PRO A 621
 ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
None
None
 1.06A 3kpbC-2j9lA:
12.3		 3kpbC-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 ILE A 722
THR A 724
ASP A 727
SER A 618
PRO A 621
 ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
ATP  A1752 (-3.3A)
None
 0.57A 3kpbC-2j9lA:
12.3		 3kpbC-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 11 ILE A 722
THR A 724
ASP A 727
SER A 618
PRO A 621
 ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
ATP  A1752 (-3.3A)
None
 0.61A 3kpcA-2j9lA:
13.0		 3kpcA-2j9lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 ILE A 722
THR A 724
ASP A 727
SER A 618
PRO A 621
 ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
ATP  A1752 (-3.3A)
None
 0.49A 3kpdC-2j9lA:
12.3		 3kpdC-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 ASP A 592
GLY A 619
LEU A 719
THR A 596
ILE A 611
 None
None
None
ATP  A1752 (-4.1A)
None
 0.89A 3pwwA-2j9lA:
undetectable		 3pwwA-2j9lA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A 640
VAL A 635
VAL A 608
LEU A 685
 None
 0.91A 3rgfA-2j9lA:
undetectable		 3rgfA-2j9lA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		3 / 3 PRO A 675
THR A 676
LEU A 669
 None
 0.72A 3ttrA-2j9lA:
undetectable		 3ttrA-2j9lA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 VAL A 713
VAL A 699
HIS A 731
ARG A 589
PRO A 588
 None
 1.49A 4bvaA-2j9lA:
undetectable		 4bvaA-2j9lA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		5 / 12 VAL A 713
VAL A 699
HIS A 731
ARG A 589
PRO A 588
 None
 1.48A 4bvaB-2j9lA:
undetectable		 4bvaB-2j9lA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2j9l CHLORIDE CHANNEL
PROTEIN 5
(Homo
sapiens) 		4 / 6 LEU A 683
LEU A 631
VAL A 632
PHE A 634
 None
 1.15A 4uswA-2j9lA:
undetectable		 4uswA-2j9lA:
17.67