SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ja2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 464
LEU A 368
LEU A 417
LEU A 414
 None
 0.92A 1errA-2ja2A:
undetectable		 1errA-2ja2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 480
ARG A 475
ALA A 455
ALA A 398
ILE A 393
 None
 1.05A 1fk6A-2ja2A:
undetectable		 1fk6A-2ja2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  23
ALA A  27
LEU A  65
LEU A  61
LEU A 284
 None
 1.32A 1gwrA-2ja2A:
undetectable		 1gwrA-2ja2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 231
LEU A 101
LEU A 232
HIS A 229
LEU A 206
 None
 1.13A 1h9zA-2ja2A:
undetectable		 1h9zA-2ja2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 471
LEU A 480
ALA A 435
ALA A 413
LEU A 464
 None
 1.29A 1kt5A-2ja2A:
undetectable		 1kt5A-2ja2A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  23
ALA A  27
LEU A  65
LEU A  61
LEU A 284
 None
 1.31A 1pcgA-2ja2A:
undetectable		 1pcgA-2ja2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  23
ALA A  27
LEU A  65
LEU A  61
LEU A 284
 None
 1.32A 1pcgB-2ja2A:
undetectable		 1pcgB-2ja2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 471
LEU A 480
ALA A 412
ALA A 435
ALA A 413
 None
 1.23A 1rbpA-2ja2A:
undetectable		 1rbpA-2ja2A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 361
PHE A 362
ALA A 366
LEU A 344
 None
 0.61A 2bxmA-2ja2A:
undetectable		 2bxmA-2ja2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 133
TYR A 132
TYR A 108
HIS A 138
 None
 1.42A 2bytA-2ja2A:
14.2		 2bytA-2ja2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 133
TYR A 132
TYR A 108
HIS A 138
 None
 1.41A 2bytD-2ja2A:
14.2		 2bytD-2ja2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 132
ASP A 133
THR A 113
GLU A 116
 None
 1.28A 2dttB-2ja2A:
undetectable
2dttC-2ja2A:
undetectable		 2dttB-2ja2A:
13.18
2dttC-2ja2A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  25
ASP A 301
LEU A 300
PHE A 298
 CL  A1487 (-4.2A)
None
None
None
 0.88A 2tsrB-2ja2A:
undetectable		 2tsrB-2ja2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 133
TYR A 132
TYR A 108
HIS A 138
 None
 1.23A 2v0gD-2ja2A:
13.5		 2v0gD-2ja2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A  88
VAL A 199
TYR A  94
ASP A  47
 None
 1.27A 2x45A-2ja2A:
undetectable		 2x45A-2ja2A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  64
LEU A  65
ALA A  27
THR A  26
 None
 0.88A 3b6hA-2ja2A:
undetectable		 3b6hA-2ja2A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 187
ARG A 234
LEU A 232
ALA A 227
 None
 1.19A 3b9mA-2ja2A:
undetectable		 3b9mA-2ja2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 436
LEU A 417
ALA A 413
LEU A 410
ALA A 454
 None
 1.29A 3e22B-2ja2A:
undetectable		 3e22B-2ja2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  27
LEU A  68
LEU A  65
LEU A  61
HIS A 270
 None
 1.17A 3erdA-2ja2A:
undetectable		 3erdA-2ja2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 471
GLY A 472
LEU A 468
ALA A 425
LEU A 368
 None
 1.02A 3gwvA-2ja2A:
undetectable		 3gwvA-2ja2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 372
LEU A 382
THR A 458
 None
 0.77A 3oxcA-2ja2A:
undetectable		 3oxcA-2ja2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 417
THR A 418
ALA A 412
ALA A 435
LEU A 436
 None
 1.04A 3p5nA-2ja2A:
undetectable		 3p5nA-2ja2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 417
THR A 418
ALA A 412
ALA A 435
LEU A 436
 None
 1.04A 3p5nB-2ja2A:
undetectable		 3p5nB-2ja2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 250
LEU A 287
TYR A 283
LEU A 267
 CL  A1487 (-4.1A)
None
None
None
 1.02A 3qeoB-2ja2A:
undetectable		 3qeoB-2ja2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 192
VAL A 156
HIS A 109
THR A 188
 None
 1.13A 3tj7A-2ja2A:
undetectable
3tj7B-2ja2A:
undetectable		 3tj7A-2ja2A:
15.27
3tj7B-2ja2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 192
VAL A 156
HIS A 109
THR A 188
 None
 1.12A 3tj7C-2ja2A:
undetectable
3tj7D-2ja2A:
undetectable		 3tj7C-2ja2A:
15.27
3tj7D-2ja2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 156
HIS A 109
THR A 188
GLY A 192
 None
 1.12A 3tj7C-2ja2A:
undetectable
3tj7D-2ja2A:
undetectable		 3tj7C-2ja2A:
15.27
3tj7D-2ja2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 MET A 334
LEU A 335
GLU A 330
HIS A 331
 None
 1.28A 4aq7A-2ja2A:
14.9		 4aq7A-2ja2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 362
GLU A 367
VAL A 337
ARG A 345
 None
 1.13A 5adeA-2ja2A:
undetectable
5adeB-2ja2A:
undetectable		 5adeA-2ja2A:
21.51
5adeB-2ja2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  23
ALA A  27
LEU A  65
LEU A  61
LEU A 284
 None
 1.31A 5dxeB-2ja2A:
undetectable		 5dxeB-2ja2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 166
PRO A 242
LEU A 213
HIS A 246
 None
 1.17A 5eskA-2ja2A:
undetectable		 5eskA-2ja2A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  23
ALA A  27
LEU A  65
LEU A  61
LEU A 284
 None
 1.36A 5hyrA-2ja2A:
undetectable		 5hyrA-2ja2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  58
ALA A  64
LEU A  65
 None
 0.32A 6ag0C-2ja2A:
undetectable		 6ag0C-2ja2A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ja2 GLUTAMYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 362
GLU A 367
VAL A 337
ARG A 345
 None
 1.15A 6av6C-2ja2A:
undetectable
6av6D-2ja2A:
undetectable		 6av6C-2ja2A:
10.00
6av6D-2ja2A:
10.00