SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ja9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 189
ASN A 191
TYR A 120
VAL A  95
 None
 0.90A 1dbbH-2ja9A:
undetectable
1dbbL-2ja9A:
undetectable		 1dbbH-2ja9A:
19.82
1dbbL-2ja9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 101
GLY A 148
LEU A  97
SER A  96
LEU A  88
 None
 0.97A 1ya4A-2ja9A:
undetectable		 1ya4A-2ja9A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 101
PHE A 102
LEU A 113
VAL A  72
VAL A 119
 None
 0.97A 3rukA-2ja9A:
undetectable		 3rukA-2ja9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 110
ASP A 117
ILE A  76
TYR A  84
 None
 0.91A 5a06B-2ja9A:
undetectable		 5a06B-2ja9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 197
LEU A 175
ILE A 194
 None
 0.75A 5kc0A-2ja9A:
undetectable		 5kc0A-2ja9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 197
LEU A 175
ILE A 194
 None
 0.82A 5kc4A-2ja9A:
undetectable		 5kc4A-2ja9A:
22.61