SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		5 / 12 GLN A  92
THR A  36
VAL A  43
LEU A 100
ILE A  78
 None
 1.28A 1kqwA-2jacA:
undetectable		 1kqwA-2jacA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  89
GLY A  87
ALA A  22
LEU A  66
ASN A  70
 GSH  A1000 (-3.2A)
GSH  A1000 (-3.5A)
None
None
None
 1.05A 3p5nA-2jacA:
undetectable		 3p5nA-2jacA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  89
GLY A  87
ALA A  22
LEU A  66
ASN A  70
 GSH  A1000 (-3.2A)
GSH  A1000 (-3.5A)
None
None
None
 1.04A 3p5nB-2jacA:
undetectable		 3p5nB-2jacA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  85
GLU A  18
LEU A 104
VAL A  43
 None
 0.88A 3ua5B-2jacA:
undetectable		 3ua5B-2jacA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A   2
SER A   3
THR A   6
 None
 0.28A 4luhA-2jacA:
undetectable		 4luhA-2jacA:
10.92