SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		4 / 4 HIS A 148
LEU A 207
LEU A 220
LEU A  68
 PIA  A  66 ( 4.2A)
None
None
PIA  A  66 ( 3.5A)
 0.93A 1a4lD-2jadA:
undetectable		 1a4lD-2jadA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		4 / 5 GLU A   5
GLY A   4
THR A   9
PHE A   8
 None
 1.34A 1icrA-2jadA:
undetectable
1icrB-2jadA:
undetectable		 1icrA-2jadA:
21.45
1icrB-2jadA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		4 / 5 GLU A   5
GLY A   4
THR A   9
PHE A   8
 None
 1.32A 1kqbA-2jadA:
undetectable
1kqbB-2jadA:
undetectable		 1kqbA-2jadA:
18.64
1kqbB-2jadA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		3 / 3 ASN A 170
LEU A 141
HIS A 169
 None
 0.85A 2q6fB-2jadA:
undetectable		 2q6fB-2jadA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
PIA  A  66 ( 3.9A)
None
None
 1.17A 3t3rB-2jadA:
undetectable		 3t3rB-2jadA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
PIA  A  66 ( 3.9A)
None
None
 1.20A 3t3rC-2jadA:
undetectable		 3t3rC-2jadA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
PIA  A  66 ( 3.9A)
None
None
 1.13A 3t3rD-2jadA:
undetectable		 3t3rD-2jadA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		4 / 7 ILE A 331
GLU A 264
LEU A 350
VAL A 289
 None
 0.82A 3ua5B-2jadA:
undetectable		 3ua5B-2jadA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		3 / 3 VAL A 248
SER A 249
THR A 252
 None
 0.30A 4luhA-2jadA:
undetectable		 4luhA-2jadA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Aequorea
victoria;
Saccharomyces
cerevisiae) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
PIA  A  66 ( 4.9A)
 0.97A 4o1zA-2jadA:
undetectable		 4o1zA-2jadA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		5 / 12 HIS A 330
ILE A 331
ALA A 268
ILE A 260
PHE A 266
 None
 1.13A 4rp8C-2jadA:
undetectable		 4rp8C-2jadA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		5 / 11 LEU A 337
GLU A 342
LEU A 346
LEU A 287
LEU A 283
 None
 1.02A 4wg0G-2jadA:
undetectable
4wg0H-2jadA:
undetectable
4wg0I-2jadA:
undetectable		 4wg0G-2jadA:
5.21
4wg0H-2jadA:
5.21
4wg0I-2jadA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		5 / 11 LEU A 337
GLU A 342
LEU A 346
LEU A 287
LEU A 283
 None
 1.12A 4wg0K-2jadA:
undetectable
4wg0L-2jadA:
undetectable
4wg0M-2jadA:
undetectable		 4wg0K-2jadA:
5.21
4wg0L-2jadA:
5.21
4wg0M-2jadA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		3 / 3 LEU A 201
ILE A 152
TYR A  92
 None
 0.67A 5uunB-2jadA:
3.9		 5uunB-2jadA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		4 / 8 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
 0.81A 6cduD-2jadA:
undetectable
6cduE-2jadA:
undetectable		 6cduD-2jadA:
21.27
6cduE-2jadA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN
(Saccharomyces
cerevisiae;
Aequorea
victoria) 		4 / 8 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
 0.88A 6cduG-2jadA:
undetectable
6cduH-2jadA:
undetectable		 6cduG-2jadA:
21.27
6cduH-2jadA:
21.27