SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 4 ARG A  25
ALA A  28
ALA A  54
GLU A  50
 None
 1.24A 1e7bA-2jahA:
undetectable		 1e7bA-2jahA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 8 LEU A  88
THR A  78
VAL A  75
ALA A  37
 None
 0.89A 1fiqC-2jahA:
undetectable		 1fiqC-2jahA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 8 THR A  23
LEU A  27
THR A 136
VAL A 181
 None
 1.15A 1o76B-2jahA:
undetectable		 1o76B-2jahA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A  14
ARG A  39
ASP A  64
ASN A  91
ALA A  92
 NDP  A1248 (-3.3A)
NDP  A1248 (-3.4A)
NDP  A1248 (-3.8A)
NDP  A1248 (-3.2A)
NDP  A1248 (-3.5A)
 0.99A 2bm9E-2jahA:
6.0		 2bm9E-2jahA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A  14
ARG A  39
ARG A  40
ASP A  64
ALA A  92
 NDP  A1248 (-3.3A)
NDP  A1248 (-3.4A)
NDP  A1248 (-4.2A)
NDP  A1248 (-3.8A)
NDP  A1248 (-3.5A)
 0.90A 2br4F-2jahA:
2.7		 2br4F-2jahA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 ALA A  10
ILE A  12
VAL A 228
ALA A 227
ILE A 183
 None
 1.10A 2h42B-2jahA:
undetectable		 2h42B-2jahA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		6 / 12 MET A  95
LEU A  97
ALA A 152
LEU A 192
TYR A 205
ARG A 208
 None
None
None
NDP  A1248 (-3.5A)
None
None
 1.35A 2japA-2jahA:
46.6		 2japA-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		11 / 12 MET A  95
LEU A  97
SER A 142
ILE A 143
ALA A 144
VAL A 149
ALA A 152
TYR A 155
THR A 187
LEU A 192
TYR A 205
 None
None
NDP  A1248 (-3.3A)
None
None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-4.6A)
NDP  A1248 (-3.5A)
None
 0.13A 2japA-2jahA:
46.6		 2japA-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		7 / 12 MET A  95
LEU A  97
ALA A 152
TYR A 155
LEU A 192
TYR A 205
ARG A 208
 None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-3.5A)
None
None
 1.25A 2japB-2jahA:
46.6		 2japB-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		11 / 12 MET A  95
LEU A  97
SER A 142
ILE A 143
ALA A 144
VAL A 149
ALA A 152
TYR A 155
THR A 187
LEU A 192
TYR A 205
 None
None
NDP  A1248 (-3.3A)
None
None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-4.6A)
NDP  A1248 (-3.5A)
None
 0.15A 2japB-2jahA:
46.6		 2japB-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		7 / 12 MET A  95
LEU A  97
ALA A 152
TYR A 155
LEU A 192
TYR A 205
ARG A 208
 None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-3.5A)
None
None
 1.19A 2japC-2jahA:
46.5		 2japC-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		11 / 12 MET A  95
LEU A  97
SER A 142
ILE A 143
ALA A 144
VAL A 149
ALA A 152
TYR A 155
THR A 187
LEU A 192
TYR A 205
 None
None
NDP  A1248 (-3.3A)
None
None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-4.6A)
NDP  A1248 (-3.5A)
None
 0.13A 2japC-2jahA:
46.5		 2japC-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		6 / 12 MET A  95
LEU A  97
ALA A 152
LEU A 192
TYR A 205
ARG A 208
 None
None
None
NDP  A1248 (-3.5A)
None
None
 1.10A 2japD-2jahA:
46.5		 2japD-2jahA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		11 / 12 MET A  95
LEU A  97
SER A 142
ILE A 143
ALA A 144
VAL A 149
ALA A 152
TYR A 155
THR A 187
LEU A 192
TYR A 205
 None
None
NDP  A1248 (-3.3A)
None
None
None
None
NDP  A1248 (-4.7A)
NDP  A1248 (-4.6A)
NDP  A1248 (-3.5A)
None
 0.14A 2japD-2jahA:
46.5		 2japD-2jahA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 8 LEU A  88
THR A  78
VAL A  75
ALA A  37
 None
 0.93A 3ax9A-2jahA:
undetectable		 3ax9A-2jahA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 4 VAL A  89
ARG A 225
ILE A 241
THR A 136
 None
 1.08A 3cl9A-2jahA:
1.7		 3cl9A-2jahA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 ALA A  92
GLY A 118
MET A 122
ASP A 113
ALA A  15
 NDP  A1248 (-3.5A)
None
None
None
None
 1.31A 3ou6C-2jahA:
6.0		 3ou6C-2jahA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A  44
ALA A  24
GLY A  20
SER A  16
LEU A  51
 None
None
None
NDP  A1248 (-2.6A)
None
 1.23A 3ou7A-2jahA:
5.7		 3ou7A-2jahA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A  44
ALA A  24
GLY A  20
SER A  16
LEU A  51
 None
None
None
NDP  A1248 (-2.6A)
None
 1.26A 3ou7D-2jahA:
5.9		 3ou7D-2jahA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 7 LEU A 215
ALA A 223
VAL A 138
ILE A 220
 None
 0.81A 3wsjB-2jahA:
undetectable		 3wsjB-2jahA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 11 ASP A 219
GLU A 222
ARG A 225
ILE A 183
THR A  23
 None
 1.49A 4urnB-2jahA:
undetectable		 4urnB-2jahA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 11 ASP A 219
GLU A 222
ARG A 225
ILE A 183
THR A  23
 None
 1.47A 4urnC-2jahA:
undetectable		 4urnC-2jahA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		4 / 4 ILE A  12
ASN A  91
ILE A 183
VAL A 224
 None
NDP  A1248 (-3.2A)
None
None
 1.04A 4uy87-2jahA:
undetectable		 4uy87-2jahA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2jah CLAVULANIC ACID
DEHYDROGENASE
(Streptomyces
clavuligerus) 		5 / 12 ALA A  10
GLY A  55
GLY A  31
LEU A   5
GLY A  48
 None
 0.97A 5i73A-2jahA:
undetectable		 5i73A-2jahA:
17.77