SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 MET A  33
VAL A  35
LEU A 190
ALA A  63
ILE A   5
 None
 1.02A 1epbA-2janA:
undetectable		 1epbA-2janA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 TRP A  98
PRO A  41
LEU A  46
LEU A 106
ALA A  37
 None
 1.45A 1hk3A-2janA:
0.4		 1hk3A-2janA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		6 / 11 GLY A  38
HIS A  47
HIS A  50
GLY A 194
ASP A 196
GLN A 197
 None
 0.89A 1jzsA-2janA:
undetectable		 1jzsA-2janA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 HIS A  47
GLY A  49
HIS A  50
GLY A 194
ASP A 196
 None
 0.79A 1pg2A-2janA:
4.9		 1pg2A-2janA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  18
LEU A 190
VAL A  35
PHE A  60
ALA A  37
 None
 1.49A 1q23D-2janA:
undetectable
1q23E-2janA:
undetectable		 1q23D-2janA:
18.72
1q23E-2janA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  49
HIS A  50
GLY A 194
ASP A 196
GLN A 197
 None
 0.99A 1qu2A-2janA:
4.9		 1qu2A-2janA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  50
GLY A 194
ASP A 196
GLN A 197
VAL A 224
 None
 0.86A 1qu2A-2janA:
4.9		 1qu2A-2janA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1603_0
(FERROCHELATASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  59
LEU A   9
PRO A  32
MET A 117
 None
 1.43A 2hrcB-2janA:
0.2		 2hrcB-2janA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 HIS A  47
GLY A  49
HIS A  50
GLY A 194
ASP A 196
 None
 0.81A 2x1lA-2janA:
6.5		 2x1lA-2janA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  47
GLY A  49
HIS A  50
GLY A 194
ASP A 196
 None
 0.86A 2x1lB-2janA:
6.4		 2x1lB-2janA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 HIS A  47
GLY A  49
HIS A  50
GLY A 194
ASP A 196
 None
 0.88A 2x1lC-2janA:
6.4		 2x1lC-2janA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 385
VAL A 383
TRP A 395
 None
 0.85A 3l8lA-2janA:
undetectable
3l8lB-2janA:
undetectable		 3l8lA-2janA:
5.45
3l8lB-2janA:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 275
LEU A 269
LEU A 307
LEU A 304
 None
 0.80A 3q1eA-2janA:
undetectable
3q1eC-2janA:
undetectable		 3q1eA-2janA:
14.66
3q1eC-2janA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 307
LEU A 304
LEU A 275
LEU A 269
 None
 0.81A 3q1eA-2janA:
undetectable
3q1eC-2janA:
undetectable		 3q1eA-2janA:
14.66
3q1eC-2janA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 241
PHE A 257
ALA A 301
THR A 305
 None
 0.89A 3t3zA-2janA:
undetectable		 3t3zA-2janA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 241
PHE A 257
ALA A 301
THR A 305
 None
 0.92A 3t3zB-2janA:
undetectable		 3t3zB-2janA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 241
PHE A 257
ALA A 301
THR A 305
 None
 0.85A 3t3zD-2janA:
undetectable		 3t3zD-2janA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A   5
LEU A   6
MET A  33
THR A  34
 None
 1.13A 3wg7A-2janA:
undetectable
3wg7J-2janA:
undetectable		 3wg7A-2janA:
23.30
3wg7J-2janA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  29
LEU A  24
LEU A   6
PHE A  60
HIS A  65
 None
 1.18A 4aqlA-2janA:
undetectable		 4aqlA-2janA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 108
GLU A 107
PHE A 112
 None
 0.99A 4kszA-2janA:
undetectable		 4kszA-2janA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  35
VAL A 205
ALA A 218
SER A  18
LEU A 219
 None
 1.39A 4m11C-2janA:
undetectable		 4m11C-2janA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  35
VAL A 205
ALA A 218
SER A  18
LEU A 219
 None
 1.41A 4m11D-2janA:
undetectable		 4m11D-2janA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  65
VAL A 221
LEU A 219
 None
 0.62A 4m2vA-2janA:
undetectable		 4m2vA-2janA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 192
VAL A  69
PRO A  67
ALA A  37
 None
 0.80A 5cu6A-2janA:
undetectable		 5cu6A-2janA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 179
ALA A 218
GLN A 197
THR A 220
 None
 1.17A 5n0tA-2janA:
3.0		 5n0tA-2janA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A  36
ALA A 218
GLN A 197
THR A 220
 None
 1.36A 5n4iA-2janA:
2.1		 5n4iA-2janA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 261
PHE A 272
LEU A 300
VAL A 224
 None
 0.52A 5nujA-2janA:
undetectable		 5nujA-2janA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 267
GLY A  13
VAL A 224
LEU A 223
ALA A 195
 None
 1.07A 5o96G-2janA:
undetectable
5o96H-2janA:
2.0		 5o96G-2janA:
21.66
5o96H-2janA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2jan TYROSYL-TRNA
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  24
LEU A   6
THR A  19
PRO A 222
GLY A 194
 None
 1.19A 6b0lB-2janA:
undetectable		 6b0lB-2janA:
10.56