SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RV7_B_AB1B1001_1 (PROTEASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	5 / 11	ASN A 150 ILE A 163 THR A 137 PRO A 158 LEU A 173	None	1.19A	1rv7A-2jarA: undetectable 1rv7B-2jarA: undetectable	1rv7A-2jarA: 20.61 1rv7B-2jarA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZ1_B_SHHB2552_1 (HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	5 / 12	LEU A 104 HIS A 169 ASP A 147 PHE A 20 PHE A 73	UMP A1200 (-4.1A) None MG A1201 (-2.6A) UMP A1200 (-4.2A) None	1.15A	1zz1B-2jarA: undetectable 1zz1C-2jarA: undetectable	1zz1B-2jarA: 19.07 1zz1C-2jarA: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_1 (SAM DEPENDENT METHYLTRANSFERASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	3 / 3	ASP A 146 ASP A 149 ASP A 14	UMP A1200 ( 4.1A) None UMP A1200 ( 3.6A)	0.66A	2igtA-2jarA: 2.4	2igtA-2jarA: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	3 / 3	ASP A 146 ASP A 149 ASP A 14	UMP A1200 ( 4.1A) None UMP A1200 ( 3.6A)	0.67A	2igtB-2jarA: 2.3	2igtB-2jarA: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I00_A_ZMRA509_2 (NEURAMINIDASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	4 / 5	LEU A 143 TRP A 160 ILE A 151 ASN A 170	None	1.43A	4i00A-2jarA: undetectable	4i00A-2jarA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_A_SASA806_1 (SEPIAPTERIN REDUCTASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	5 / 12	LEU A 104 CYH A 110 PHE A 73 ASP A 19 GLY A 15	UMP A1200 (-4.1A) UMP A1200 ( 4.5A) None None MG A1201 ( 4.5A)	1.08A	4j7xA-2jarA: undetectable	4j7xA-2jarA: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_F_SASF805_1 (SEPIAPTERIN REDUCTASE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	5 / 12	LEU A 104 CYH A 110 PHE A 73 ASP A 19 GLY A 15	UMP A1200 (-4.1A) UMP A1200 ( 4.5A) None None MG A1201 ( 4.5A)	1.11A	4j7xF-2jarA: undetectable	4j7xF-2jarA: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWZ_A_SAMA301_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	3 / 3	SER A 22 ASP A 147 ASP A 149	None MG A1201 (-2.6A) None	0.91A	4mwzA-2jarA: undetectable	4mwzA-2jarA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WCX_C_SAMC503_0 (BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED)	2jar	5'(3')-DEOXYRIBONUCL EOTIDASE (Mus musculus)	5 / 12	TYR A 115 GLY A 112 GLU A 113 LEU A 17 LEU A 86	None	1.23A	4wcxC-2jarA: undetectable	4wcxC-2jarA: 17.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RV7_B_AB1B1001_1","PROTEASE;PROTEASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",5,"ASN A 150;ILE A 163;THR A 137;PRO A 158;LEU A 173","None","1.19A","1rv7A-2jarA:undetectable;1rv7B-2jarA:undetectable","1rv7A-2jarA:20.61;1rv7B-2jarA:20.61"],["1ZZ1_B_SHHB2552_1","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE;HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",5,"LEU A 104;HIS A 169;ASP A 147;PHE A  20;PHE A  73","UMP A1200 (-4.1A);None; MG A1201 (-2.6A);UMP A1200 (-4.2A);None","1.15A","1zz1B-2jarA:undetectable;1zz1C-2jarA:undetectable","1zz1B-2jarA:19.07;1zz1C-2jarA:19.07"],["2IGT_A_SAMA1001_1","SAM DEPENDENT METHYLTRANSFERASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",3,"ASP A 146;ASP A 149;ASP A  14","UMP A1200 ( 4.1A);None;UMP A1200 ( 3.6A)","0.66A","2igtA-2jarA:2.4","2igtA-2jarA:21.87"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",3,"ASP A 146;ASP A 149;ASP A  14","UMP A1200 ( 4.1A);None;UMP A1200 ( 3.6A)","0.67A","2igtB-2jarA:2.3","2igtB-2jarA:21.87"],["4I00_A_ZMRA509_2","NEURAMINIDASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",4,"LEU A 143;TRP A 160;ILE A 151;ASN A 170","None","1.43A","4i00A-2jarA:undetectable","4i00A-2jarA:16.67"],["4J7X_A_SASA806_1","SEPIAPTERIN REDUCTASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",5,"LEU A 104;CYH A 110;PHE A  73;ASP A  19;GLY A  15","UMP A1200 (-4.1A);UMP A1200 ( 4.5A);None;None; MG A1201 ( 4.5A)","1.08A","4j7xA-2jarA:undetectable","4j7xA-2jarA:21.99"],["4J7X_F_SASF805_1","SEPIAPTERIN REDUCTASE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",5,"LEU A 104;CYH A 110;PHE A  73;ASP A  19;GLY A  15","UMP A1200 (-4.1A);UMP A1200 ( 4.5A);None;None; MG A1201 ( 4.5A)","1.11A","4j7xF-2jarA:undetectable","4j7xF-2jarA:21.99"],["4MWZ_A_SAMA301_1","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",3,"SER A  22;ASP A 147;ASP A 149","None; MG A1201 (-2.6A);None","0.91A","4mwzA-2jarA:undetectable","4mwzA-2jarA:20.30"],["4WCX_C_SAMC503_0","BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED","2jar","5'(3')-DEOXYRIBONUCLEOTIDASE","Mus musculus",5,"TYR A 115;GLY A 112;GLU A 113;LEU A  17;LEU A  86","None","1.23A","4wcxC-2jarA:undetectable","4wcxC-2jarA:17.05"]]