SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  91
VAL A  24
ILE A  10
LEU A  40
 None
 0.86A 1igxA-2jaxA:
undetectable		 1igxA-2jaxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.48A 1q23C-2jaxA:
undetectable		 1q23C-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.44A 1q23H-2jaxA:
undetectable		 1q23H-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.50A 1q23G-2jaxA:
undetectable		 1q23G-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.56A 1q23L-2jaxA:
undetectable		 1q23L-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.48A 1q23J-2jaxA:
undetectable		 1q23J-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  27
ALA A  20
GLY A 117
GLY A  13
ILE A  14
 None
ATP  A1296 (-2.6A)
ATP  A1296 (-2.5A)
ATP  A1296 (-3.3A)
None
 1.14A 2v7bA-2jaxA:
3.0		 2v7bA-2jaxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  27
ALA A  20
GLY A 117
GLY A  13
ILE A  14
 None
ATP  A1296 (-2.6A)
ATP  A1296 (-2.5A)
ATP  A1296 (-3.3A)
None
 1.14A 2v7bB-2jaxA:
3.5		 2v7bB-2jaxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  15
SER A  17
ARG A 123
 ATP  A1296 (-3.2A)
ATP  A1296 ( 4.2A)
None
 1.00A 3loqA-2jaxA:
22.6		 3loqA-2jaxA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 120
ILE A  72
GLY A  13
ALA A  20
ALA A  75
 ATP  A1296 (-3.2A)
None
ATP  A1296 (-3.3A)
ATP  A1296 (-2.6A)
None
 0.99A 3sudC-2jaxA:
undetectable		 3sudC-2jaxA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  14
VAL A 115
LEU A 113
ILE A  11
 None
 0.73A 4asdA-2jaxA:
undetectable		 4asdA-2jaxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  27
ALA A  20
GLY A 117
GLY A  13
ILE A  14
 None
ATP  A1296 (-2.6A)
ATP  A1296 (-2.5A)
ATP  A1296 (-3.3A)
None
 1.11A 4eatB-2jaxA:
undetectable		 4eatB-2jaxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 266
LEU A 193
PRO A 245
VAL A 241
VAL A 239
 ATP  A1295 ( 4.6A)
None
ATP  A1295 (-4.6A)
None
None
 1.44A 4mjrA-2jaxA:
undetectable		 4mjrA-2jaxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2jax HYPOTHETICAL PROTEIN
TB31.7
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  15
SER A 121
ASP A  16
HIS A  67
 ATP  A1296 (-3.2A)
None
None
None
 1.42A 5wyqB-2jaxA:
0.5		 5wyqB-2jaxA:
21.82