SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 137
LEU A 140
VAL A 144
ALA A 150
 None
 0.72A 1mz9A-2jayA:
undetectable		 1mz9A-2jayA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 137
LEU A 140
VAL A 144
ALA A 150
 None
 0.73A 1mz9C-2jayA:
undetectable		 1mz9C-2jayA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 216
LEU A 221
GLY A 220
ARG A 266
 None
 1.46A 2j2pD-2jayA:
0.0
2j2pE-2jayA:
0.0		 2j2pD-2jayA:
22.04
2j2pE-2jayA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 253
PRO A 249
LEU A 270
ILE A 267
 None
 1.01A 2q83B-2jayA:
undetectable		 2q83B-2jayA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 163
GLY A 175
GLY A  68
LEU A 161
PHE A 180
 None
 0.90A 3ihtA-2jayA:
undetectable		 3ihtA-2jayA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 163
TYR A 164
GLY A  68
ASP A 255
 None
 1.20A 3kl3A-2jayA:
undetectable		 3kl3A-2jayA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 204
SER A 179
GLN A 194
 None
 1.23A 3si7A-2jayA:
undetectable		 3si7A-2jayA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		5 / 12 SER A 219
GLY A  68
GLY A  67
ASP A 165
PHE A 133
 None
 1.10A 4pghD-2jayA:
undetectable		 4pghD-2jayA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		4 / 6 THR A  94
ALA A  99
THR A 100
VAL A  91
 None
 0.86A 5ecoA-2jayA:
undetectable		 5ecoA-2jayA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  68
VAL A 214
ALA A  62
LEU A  63
ALA A 224
 None
 0.92A 5kpcA-2jayA:
undetectable		 5kpcA-2jayA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		5 / 11 TYR A 211
ASP A 216
THR A 215
GLY A  68
ASP A 255
 None
 1.39A 6mb5A-2jayA:
undetectable		 6mb5A-2jayA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 2jay PROTEASOME
(Mycobacterium
tuberculosis) 		5 / 10 TYR A 211
ASP A 216
THR A 215
GLY A  68
ASP A 255
 None
 1.44A 6mb9D-2jayA:
0.0		 6mb9D-2jayA:
14.78