SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 GLY A 124
GLN A 125
VAL A 114
SER A 214
 None
 1.16A 1p6kB-2jb1A:
undetectable		 1p6kB-2jb1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 ARG A  44
ARG A  46
ILE A 255
 FAD  A1489 (-3.9A)
None
None
 0.80A 1uobA-2jb1A:
undetectable		 1uobA-2jb1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 GLY A 124
GLN A 125
VAL A 114
SER A 214
 None
 1.15A 1zzuB-2jb1A:
undetectable		 1zzuB-2jb1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 ARG A  55
VAL A 368
GLY A 322
 None
 0.56A 2avvE-2jb1A:
undetectable		 2avvE-2jb1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 ALA A  23
THR A 292
PHE A 246
 FAD  A1489 (-3.2A)
FAD  A1489 ( 4.7A)
None
 0.79A 2c6nB-2jb1A:
undetectable		 2c6nB-2jb1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 ARG A  44
VAL A  17
THR A 292
 FAD  A1489 (-3.9A)
None
FAD  A1489 ( 4.7A)
 0.80A 2nmzA-2jb1A:
undetectable		 2nmzA-2jb1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 ARG A  44
VAL A  17
THR A 292
 FAD  A1489 (-3.9A)
None
FAD  A1489 ( 4.7A)
 0.85A 2nnkA-2jb1A:
undetectable		 2nnkA-2jb1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		5 / 12 ARG A 331
TYR A 404
ILE A 326
GLY A 342
TYR A 357
 None
 1.48A 2nyrB-2jb1A:
4.1		 2nyrB-2jb1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 7 VAL A 261
LEU A 301
TYR A 275
ILE A 284
 FAD  A1489 (-3.7A)
None
None
None
 1.04A 3avpA-2jb1A:
undetectable		 3avpA-2jb1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		5 / 9 THR A 311
VAL A 309
LEU A 447
ALA A 316
ALA A 315
 None
 1.20A 3ax7B-2jb1A:
undetectable		 3ax7B-2jb1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 ARG A  44
VAL A  17
THR A 292
 FAD  A1489 (-3.9A)
None
FAD  A1489 ( 4.7A)
 0.85A 3pwrA-2jb1A:
undetectable		 3pwrA-2jb1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 ASP A 358
GLY A 237
TYR A 357
GLN A 103
 None
 1.15A 3w9tB-2jb1A:
undetectable		 3w9tB-2jb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1004_1
(HEMOLYTIC LECTIN
CEL-III)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 4 ASP A 358
GLY A 237
TYR A 357
GLN A 103
 None
 1.15A 3w9tC-2jb1A:
0.0		 3w9tC-2jb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 ASP A 358
GLY A 237
TYR A 357
GLN A 103
 None
 1.21A 3w9tD-2jb1A:
undetectable		 3w9tD-2jb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 ASP A 358
GLY A 237
TYR A 357
GLN A 103
 None
 1.19A 3w9tE-2jb1A:
undetectable		 3w9tE-2jb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 ASP A 358
GLY A 237
TYR A 357
GLN A 103
 None
 1.21A 3w9tG-2jb1A:
undetectable		 3w9tG-2jb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		3 / 3 TYR A 360
ARG A 331
HIS A 359
 None
 1.22A 4fubA-2jb1A:
undetectable		 4fubA-2jb1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		5 / 12 GLY A  20
PRO A  47
PHE A 246
VAL A  40
ILE A 250
 FAD  A1489 ( 4.6A)
None
None
None
None
 1.11A 4rvdA-2jb1A:
2.7		 4rvdA-2jb1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		5 / 12 GLY A  20
PRO A  47
PHE A 246
VAL A  40
ILE A 250
 FAD  A1489 ( 4.6A)
None
None
None
None
 1.10A 4rvgA-2jb1A:
2.7		 4rvgA-2jb1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 6 GLU A  30
TYR A  94
LEU A  98
PHE A  29
 None
 1.23A 4twdB-2jb1A:
undetectable
4twdC-2jb1A:
undetectable		 4twdB-2jb1A:
22.04
4twdC-2jb1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 6 GLU A  30
TYR A  94
LEU A  98
PHE A  29
 None
 1.18A 4twdD-2jb1A:
undetectable
4twdE-2jb1A:
undetectable		 4twdD-2jb1A:
22.04
4twdE-2jb1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 7 GLU A  30
TYR A  94
LEU A  98
PHE A  29
 None
 1.14A 4twdF-2jb1A:
undetectable
4twdJ-2jb1A:
undetectable		 4twdF-2jb1A:
22.04
4twdJ-2jb1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 6 GLU A  30
TYR A  94
LEU A  98
PHE A  29
 None
 1.08A 4twdF-2jb1A:
undetectable
4twdG-2jb1A:
undetectable		 4twdF-2jb1A:
22.04
4twdG-2jb1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 6 GLU A  30
TYR A  94
LEU A  98
PHE A  29
 None
 1.10A 4twdI-2jb1A:
undetectable
4twdJ-2jb1A:
undetectable		 4twdI-2jb1A:
22.04
4twdJ-2jb1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 6 PHE A 246
PRO A  22
THR A  91
ILE A 242
 None
FAD  A1489 (-3.7A)
None
None
 1.34A 5ih0A-2jb1A:
undetectable		 5ih0A-2jb1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 5 GLY A 124
GLN A 125
VAL A 114
SER A 214
 None
 1.22A 5vunA-2jb1A:
undetectable		 5vunA-2jb1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2jb1 L-AMINO ACID OXIDASE
(Rhodococcus
opacus) 		4 / 8 ASP A 363
SER A 362
GLY A  56
SER A  58
 None
 1.07A 6giqL-2jb1A:
undetectable
6giqP-2jb1A:
undetectable
6giqT-2jb1A:
undetectable		 6giqL-2jb1A:
21.65
6giqP-2jb1A:
18.78
6giqT-2jb1A:
10.56