SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		5 / 9 GLU A  69
ASN A  72
ILE A  75
ALA A  51
VAL A  61
 None
 1.36A 2drdA-2jb7A:
4.2		 2drdA-2jb7A:
9.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		7 / 10 ASN A  20
TRP A  95
ILE A  97
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.22A 2gl0A-2jb7A:
29.6
2gl0B-2jb7A:
29.8		 2gl0A-2jb7A:
98.20
2gl0B-2jb7A:
98.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		8 / 11 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.17A 2gl0B-2jb7A:
29.8
2gl0C-2jb7A:
29.8		 2gl0B-2jb7A:
98.20
2gl0C-2jb7A:
98.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		8 / 12 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.24A 2gl0A-2jb7A:
29.6
2gl0C-2jb7A:
29.8		 2gl0A-2jb7A:
98.20
2gl0C-2jb7A:
98.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		8 / 12 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.17A 2gl0D-2jb7A:
29.8
2gl0E-2jb7A:
29.5		 2gl0D-2jb7A:
98.20
2gl0E-2jb7A:
98.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		8 / 11 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.17A 2gl0E-2jb7A:
29.5
2gl0F-2jb7A:
29.7		 2gl0E-2jb7A:
98.20
2gl0F-2jb7A:
98.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		8 / 11 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.22A 2gl0D-2jb7A:
29.8
2gl0F-2jb7A:
29.7		 2gl0D-2jb7A:
98.20
2gl0F-2jb7A:
98.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		4 / 8 ILE A  89
ALA A 115
ILE A 103
PHE A  87
 None
 0.71A 2w9sE-2jb7A:
undetectable		 2w9sE-2jb7A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2jb7 HYPOTHETICAL PROTEIN
PAE2307
(Pyrobaculum
aerophilum) 		5 / 10 ILE A  81
VAL A  86
ILE A  22
VAL A  13
VAL A 122
 None
 1.08A 4j5jB-2jb7A:
undetectable		 4j5jB-2jb7A:
20.12