SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 8 LEU A  56
ILE A  92
GLY A  65
ILE A  64
LEU A  85
 None
None
None
None
CAS  A  82 ( 4.5A)
 1.15A 2o4nB-2jbhA:
undetectable		 2o4nB-2jbhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A  64
SER A 101
GLY A  65
SER A  93
LEU A 138
 None
 1.42A 3ik6B-2jbhA:
undetectable
3ik6E-2jbhA:
undetectable		 3ik6B-2jbhA:
22.81
3ik6E-2jbhA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 SER A  93
LEU A 138
ILE A  64
SER A 101
GLY A  65
 None
 1.40A 3iluB-2jbhA:
undetectable
3iluE-2jbhA:
undetectable		 3iluB-2jbhA:
22.81
3iluE-2jbhA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A  64
SER A 101
GLY A  65
SER A  93
LEU A 138
 None
 1.38A 3iluB-2jbhA:
undetectable
3iluE-2jbhA:
undetectable		 3iluB-2jbhA:
22.81
3iluE-2jbhA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 145
GLY A 147
THR A 149
 5GP  A1230 (-3.3A)
5GP  A1230 (-3.5A)
5GP  A1230 (-3.6A)
 0.24A 3si7B-2jbhA:
undetectable		 3si7B-2jbhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 202
ILE A 215
GLY A 197
PHE A 206
 None
 0.65A 4iqqA-2jbhA:
undetectable		 4iqqA-2jbhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 202
ILE A 215
GLY A 197
PHE A 206
 None
 0.78A 4iqqC-2jbhA:
undetectable		 4iqqC-2jbhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 202
ILE A 215
GLY A 197
PHE A 206
 None
 0.75A 4iqqD-2jbhA:
undetectable		 4iqqD-2jbhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 138
VAL A  71
GLY A  65
VAL A 100
VAL A 104
 None
None
None
None
CAS  A  82 ( 4.2A)
 0.82A 4m2vA-2jbhA:
undetectable		 4m2vA-2jbhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A  81
ALA A 199
SER A 169
LEU A 170
VAL A 143
 CAS  A  82 ( 4.7A)
None
None
None
5GP  A1230 (-4.0A)
 1.11A 4or0A-2jbhA:
undetectable		 4or0A-2jbhA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 155
GLY A 180
ASP A 179
GLY A 147
 None
None
None
5GP  A1230 (-3.5A)
 0.86A 5cdnA-2jbhA:
undetectable
5cdnB-2jbhA:
2.7		 5cdnA-2jbhA:
19.27
5cdnB-2jbhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 155
GLY A 180
ASP A 179
GLY A 147
 None
None
None
5GP  A1230 (-3.5A)
 0.91A 5cdnR-2jbhA:
undetectable
5cdnS-2jbhA:
2.7		 5cdnR-2jbhA:
19.27
5cdnS-2jbhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  65
ARG A  98
ILE A  92
ASN A 136
PHE A  99
 None
 1.12A 5fa8A-2jbhA:
undetectable		 5fa8A-2jbhA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 202
ILE A 215
GLY A 197
PHE A 206
 None
 0.67A 5nooA-2jbhA:
undetectable		 5nooA-2jbhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 202
ILE A 215
GLY A 197
PHE A 206
 None
 0.74A 5nooD-2jbhA:
undetectable		 5nooD-2jbhA:
21.32