SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 238
ALA A 216
ALA A 214
VAL A 237
GLN A 208
 None
 1.18A 1kt4A-2jbmA:
undetectable		 1kt4A-2jbmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 169
ALA A 137
SER A 250
MET A 171
LEU A 222
 None
None
None
SRT  A 401 ( 4.9A)
None
 1.43A 1ya3B-2jbmA:
undetectable		 1ya3B-2jbmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 5 GLY A  58
GLN A  59
VAL A 156
SER A 114
 None
 1.30A 1zzqB-2jbmA:
undetectable		 1zzqB-2jbmA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 5 GLY A  58
GLN A  59
VAL A 156
SER A 114
 None
 1.31A 1zzuA-2jbmA:
undetectable		 1zzuA-2jbmA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		3 / 3 PHE A  62
VAL A  73
TRP A  75
 None
 0.79A 2cc8A-2jbmA:
undetectable		 2cc8A-2jbmA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		3 / 3 PHE A  62
VAL A  73
TRP A  75
 None
 0.80A 2ccbA-2jbmA:
undetectable		 2ccbA-2jbmA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 6 SER A 250
ASP A 224
SER A 270
VAL A 268
 None
 1.11A 2hdnI-2jbmA:
undetectable
2hdnJ-2jbmA:
undetectable
2hdnL-2jbmA:
2.1		 2hdnI-2jbmA:
9.47
2hdnJ-2jbmA:
22.91
2hdnL-2jbmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 6 SER A 270
VAL A 268
SER A 250
ASP A 224
 None
 1.15A 2hdnJ-2jbmA:
undetectable
2hdnK-2jbmA:
undetectable
2hdnL-2jbmA:
2.2		 2hdnJ-2jbmA:
22.91
2hdnK-2jbmA:
9.47
2hdnL-2jbmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		3 / 3 PHE A  62
VAL A  73
TRP A  75
 None
 0.80A 2vx9A-2jbmA:
undetectable		 2vx9A-2jbmA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 8 ALA A 278
GLY A 153
LEU A 154
GLY A 138
 None
 0.63A 2yfxA-2jbmA:
undetectable		 2yfxA-2jbmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 6 ALA A 249
LEU A 223
ALA A 235
THR A 236
 None
 0.87A 3b6hA-2jbmA:
undetectable		 3b6hA-2jbmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 6 ALA A 249
LEU A 223
ALA A 235
THR A 236
 None
 0.89A 3b6hB-2jbmA:
undetectable		 3b6hB-2jbmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 11 LEU A 238
ALA A 218
ALA A 214
VAL A 237
GLN A 208
 None
 1.19A 3bszE-2jbmA:
undetectable		 3bszE-2jbmA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A  69
TRP A  49
GLY A 102
LEU A 100
ALA A  47
 None
 1.29A 3ou6C-2jbmA:
undetectable		 3ou6C-2jbmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A  69
TRP A  49
GLY A 102
LEU A 100
ALA A  47
 None
 1.32A 3ou7C-2jbmA:
undetectable		 3ou7C-2jbmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 VAL A 136
ALA A 159
GLY A 158
ALA A 278
LEU A 258
 None
 1.13A 3qxyA-2jbmA:
undetectable		 3qxyA-2jbmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 11 VAL A 136
ALA A 159
GLY A 158
ALA A 278
LEU A 258
 None
 1.15A 3rc0A-2jbmA:
undetectable		 3rc0A-2jbmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 VAL A 136
ALA A 159
GLY A 158
ALA A 278
LEU A 258
 None
 1.16A 3rc0B-2jbmA:
undetectable		 3rc0B-2jbmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 10 ALA A 111
LEU A 110
PHE A  62
ALA A  90
ALA A  87
 None
 1.11A 4j14A-2jbmA:
undetectable		 4j14A-2jbmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 8 VAL A 156
VAL A 149
TRP A  75
LEU A  56
 None
 1.02A 4puoC-2jbmA:
4.7		 4puoC-2jbmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 10 GLY A  58
GLN A  59
PHE A  62
ALA A  90
ALA A  50
 None
 1.18A 4wnuD-2jbmA:
undetectable		 4wnuD-2jbmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		3 / 3 LEU A 101
VAL A  21
ASP A  22
 None
 0.53A 4y8wC-2jbmA:
undetectable		 4y8wC-2jbmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		4 / 6 PHE A  61
SER A 114
ALA A  57
LEU A 110
 None
 1.33A 5dzkg-2jbmA:
2.7
5dzku-2jbmA:
undetectable		 5dzkg-2jbmA:
22.07
5dzku-2jbmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A  20
GLY A 145
VAL A 149
ARG A 147
GLY A 167
 None
 1.35A 5f9zA-2jbmA:
undetectable		 5f9zA-2jbmA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		3 / 3 LEU A 231
VAL A 247
ASP A 267
 None
 0.66A 5x23A-2jbmA:
undetectable		 5x23A-2jbmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 10 LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
 None
 1.32A 6bsgA-2jbmA:
4.0		 6bsgA-2jbmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 10 LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
 None
 1.33A 6bsiA-2jbmA:
4.3		 6bsiA-2jbmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 10 LEU A 110
VAL A 156
GLY A 153
TRP A  75
LEU A  56
 None
 1.49A 6bsjA-2jbmA:
4.2		 6bsjA-2jbmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 10 LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
 None
 1.32A 6bsjA-2jbmA:
4.2		 6bsjA-2jbmA:
11.71