SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		4 / 7 PHE A 124
LEU A 127
ASN A 148
ASP A 146
 None
None
ACT  A1260 ( 4.7A)
None
 0.90A 1yc2E-2jc4A:
undetectable		 1yc2E-2jc4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		3 / 3 ARG A 189
ASN A 148
THR A 199
 None
ACT  A1260 ( 4.7A)
None
 0.89A 2q63A-2jc4A:
undetectable		 2q63A-2jc4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		4 / 6 TYR A  62
SER A  57
GLN A  39
ASP A  86
 2HP  A1261 ( 4.0A)
None
None
None
 1.31A 2zvjA-2jc4A:
undetectable		 2zvjA-2jc4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		4 / 6 ASP A 202
ASP A 217
HIS A 247
ASP A 146
 None
 1.15A 3c0zC-2jc4A:
undetectable		 3c0zC-2jc4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		5 / 12 LEU A 143
LEU A 144
GLY A 145
VAL A  65
ILE A  67
 None
 1.05A 4c9oA-2jc4A:
undetectable		 4c9oA-2jc4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		5 / 12 LEU A 143
LEU A 144
GLY A 145
VAL A  65
ILE A  67
 None
 1.04A 4c9oB-2jc4A:
undetectable		 4c9oB-2jc4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		5 / 12 CYH A  54
PHE A  42
GLN A  19
ALA A  46
LEU A  15
 None
 1.30A 4j7xB-2jc4A:
3.2		 4j7xB-2jc4A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		3 / 3 TYR A 203
ARG A  14
SER A 245
 None
 1.12A 4lf7I-2jc4A:
undetectable
4lf7J-2jc4A:
undetectable		 4lf7I-2jc4A:
18.50
4lf7J-2jc4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		3 / 3 TYR A 203
ARG A  14
SER A 245
 None
 1.12A 4lf8I-2jc4A:
undetectable
4lf8J-2jc4A:
undetectable		 4lf8I-2jc4A:
18.50
4lf8J-2jc4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		4 / 7 GLY A 145
TRP A 123
GLN A  88
TYR A 119
 None
None
2HP  A1261 ( 3.9A)
None
 1.18A 5vlmG-2jc4A:
undetectable		 5vlmG-2jc4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		3 / 3 GLN A  59
TYR A  62
ASN A  63
 None
2HP  A1261 ( 4.0A)
None
 0.56A 6dwdC-2jc4A:
undetectable		 6dwdC-2jc4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		3 / 3 ASP A 186
ASP A 231
ASN A  25
 None
 0.79A 6gngB-2jc4A:
undetectable		 6gngB-2jc4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2jc4 EXODEOXYRIBONUCLEASE
III
(Neisseria
meningitidis) 		4 / 7 ALA A 206
GLY A 205
GLY A 213
TYR A 157
 None
 0.76A 6nm4A-2jc4A:
undetectable		 6nm4A-2jc4A:
19.76