SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		5 / 12 PHE A 234
PHE A 230
GLN A 247
ALA A 282
MET A 224
 None
None
TRS  A1369 (-4.0A)
MN  A1367 ( 4.9A)
None
 1.38A 1fm4A-2jcjA:
undetectable		 1fm4A-2jcjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 8 MET A 354
PHE A 147
ALA A 282
ILE A 283
 None
None
MN  A1367 ( 4.9A)
None
 1.19A 1pnlA-2jcjA:
undetectable
1pnlB-2jcjA:
undetectable		 1pnlA-2jcjA:
23.55
1pnlB-2jcjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 5 VAL A 136
TYR A 139
VAL A 226
ASP A 225
 UDP  A1366 (-3.8A)
UDP  A1366 (-3.4A)
UDP  A1366 (-4.1A)
MN  A1367 ( 3.1A)
 1.22A 2x45A-2jcjA:
undetectable		 2x45A-2jcjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 7 GLU A 110
GLU A 336
TYR A 113
SER A 334
 None
 1.24A 2zt7A-2jcjA:
undetectable		 2zt7A-2jcjA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 7 GLY A 275
ASP A 257
TRP A 250
TYR A 260
 None
 0.93A 3arrA-2jcjA:
undetectable		 3arrA-2jcjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 7 GLY A 275
ASP A 257
TRP A 250
TYR A 260
 None
 0.96A 3aruA-2jcjA:
undetectable		 3aruA-2jcjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 5 THR A 295
ILE A 206
PHE A 284
LEU A 221
 None
 1.49A 3tf1A-2jcjA:
undetectable		 3tf1A-2jcjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 8 ASP A 348
MET A 100
VAL A 107
THR A  99
 None
 1.15A 4lnwA-2jcjA:
undetectable		 4lnwA-2jcjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		3 / 3 ASP A 227
TYR A 143
TRP A 356
 MN  A1367 ( 2.2A)
None
None
 1.34A 4p7nA-2jcjA:
undetectable		 4p7nA-2jcjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 6 ARG A 138
ASP A 168
LYS A 188
ILE A 140
 None
 1.40A 5a06A-2jcjA:
undetectable		 5a06A-2jcjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 8 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.03A 5vlmB-2jcjA:
undetectable		 5vlmB-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 7 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.09A 5vlmE-2jcjA:
undetectable		 5vlmE-2jcjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE
(Bos
taurus) 		4 / 7 GLY A 286
GLN A 125
TYR A 121
ASP A 219
 None
 1.13A 5vlmG-2jcjA:
undetectable		 5vlmG-2jcjA:
21.79