SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		3 / 3 ALA A  86
VAL A  88
TRP A 352
 None
 0.90A 1grmA-2jdxA:
undetectable		 1grmA-2jdxA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		3 / 3 ALA A  86
VAL A  88
TRP A 352
 None
 0.90A 1grmB-2jdxA:
undetectable		 1grmB-2jdxA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		3 / 3 ASP A 298
GLU A 101
TYR A 227
 None
 0.85A 1wsvA-2jdxA:
undetectable		 1wsvA-2jdxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 7 PHE A 244
TYR A 227
ASN A 224
ARG A 269
 None
 1.25A 1wu8A-2jdxA:
undetectable
1wu8C-2jdxA:
undetectable		 1wu8A-2jdxA:
18.93
1wu8C-2jdxA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		3 / 3 ASP A 298
ILE A 229
VAL A 272
 None
 0.70A 2avvD-2jdxA:
undetectable		 2avvD-2jdxA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 ALA A 261
THR A 307
PHE A 296
ILE A 294
PHE A 308
 None
 1.19A 2v95A-2jdxA:
undetectable		 2v95A-2jdxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 6 ARG A 142
ILE A  79
ILE A 395
LEU A 401
 None
 0.96A 2xkwB-2jdxA:
undetectable		 2xkwB-2jdxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 7 SER A 160
LEU A 163
SER A 188
THR A 161
 None
 0.86A 3cfqA-2jdxA:
undetectable
3cfqB-2jdxA:
undetectable		 3cfqA-2jdxA:
14.56
3cfqB-2jdxA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 GLU A 192
TYR A 193
ILE A 180
ALA A 213
ASP A 254
 None
 0.92A 3nmuB-2jdxA:
undetectable
3nmuJ-2jdxA:
undetectable		 3nmuB-2jdxA:
19.32
3nmuJ-2jdxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		3 / 3 SER A 359
ASP A 305
ASP A 254
 None
 0.92A 3uj7A-2jdxA:
undetectable		 3uj7A-2jdxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 PRO A 216
THR A 247
LEU A 222
TYR A 227
GLN A 271
 None
 1.44A 3zqeA-2jdxA:
0.0
3zqeB-2jdxA:
0.0		 3zqeA-2jdxA:
21.53
3zqeB-2jdxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 ALA A 261
THR A 307
PHE A 296
ILE A 294
PHE A 308
 None
 1.16A 4c49A-2jdxA:
undetectable		 4c49A-2jdxA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 6 PHE A 115
ALA A  86
PRO A  90
LEU A 163
 None
 0.99A 4dtzA-2jdxA:
undetectable		 4dtzA-2jdxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 6 PHE A 115
ALA A  86
PRO A  90
LEU A 163
 None
 0.98A 4dtzB-2jdxA:
undetectable		 4dtzB-2jdxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 7 PHE A 115
ALA A  86
PRO A  90
LEU A 163
 None
 0.90A 4du2A-2jdxA:
undetectable		 4du2A-2jdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 8 SER A 160
LEU A 163
SER A 188
THR A 161
 None
 0.91A 4ikjA-2jdxA:
undetectable
4ikjB-2jdxA:
undetectable		 4ikjA-2jdxA:
14.62
4ikjB-2jdxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 8 LEU A 163
SER A 188
THR A 161
SER A 160
 None
 0.90A 4ikkA-2jdxA:
undetectable
4ikkB-2jdxA:
undetectable		 4ikkA-2jdxA:
14.62
4ikkB-2jdxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 7 SER A 160
LEU A 163
SER A 188
THR A 161
 None
 0.94A 4ikkA-2jdxA:
undetectable
4ikkB-2jdxA:
undetectable		 4ikkA-2jdxA:
14.62
4ikkB-2jdxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 PRO A  89
HIS A 303
GLY A 402
ASP A 254
LEU A 163
 None
 1.35A 5eeiA-2jdxA:
undetectable		 5eeiA-2jdxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 PRO A  89
HIS A 303
GLY A 402
ASP A 254
LEU A 163
 None
 1.32A 5eeiB-2jdxA:
undetectable		 5eeiB-2jdxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		4 / 4 GLN A 271
VAL A 245
GLU A  94
ILE A  93
 None
 1.28A 5jncA-2jdxA:
0.0		 5jncA-2jdxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 ASN A 361
PHE A 405
LEU A 358
ASN A 399
ILE A 133
 None
 1.48A 6dwnB-2jdxA:
undetectable		 6dwnB-2jdxA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 10 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
 None
 1.08A 6ebpD-2jdxA:
undetectable		 6ebpD-2jdxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
 None
 1.06A 6ebzA-2jdxA:
undetectable		 6ebzA-2jdxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
 None
 1.06A 6ebzB-2jdxA:
undetectable		 6ebzB-2jdxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
 None
 1.05A 6ebzD-2jdxA:
undetectable		 6ebzD-2jdxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 ASP A 170
ASN A 361
LEU A 358
GLY A 404
MET A 167
 None
 1.04A 6exiA-2jdxA:
undetectable		 6exiA-2jdxA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 12 ASP A 170
ASN A 361
LEU A 358
GLY A 404
MET A 167
 None
 1.04A 6exiD-2jdxA:
undetectable		 6exiD-2jdxA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
 None
 1.03A 6gp2A-2jdxA:
undetectable		 6gp2A-2jdxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens) 		5 / 11 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
 None
 1.05A 6gp2B-2jdxA:
undetectable		 6gp2B-2jdxA:
12.10