SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2je1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 8 LEU A  44
PHE A  46
LEU A  69
LEU A  66
 None
 0.94A 1e7cA-2je1A:
undetectable		 1e7cA-2je1A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		5 / 12 ILE A  57
PHE A  41
ASN A  74
ILE A   7
THR A  49
 None
 1.14A 2rlcA-2je1A:
undetectable		 2rlcA-2je1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 6 LEU A 120
GLY A  97
LEU A 118
SER A 117
 None
 0.87A 3aiaA-2je1A:
undetectable		 3aiaA-2je1A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 7 LEU A  34
LEU A 112
VAL A  82
LEU A 120
 None
 0.91A 3g8iA-2je1A:
undetectable		 3g8iA-2je1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 7 ARG A 132
ASP A 146
ASP A 119
PHE A 136
 None
 1.14A 3kivA-2je1A:
undetectable		 3kivA-2je1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		3 / 3 LEU A  24
MET A   3
ASP A  18
 None
 0.57A 4j7xB-2je1A:
undetectable		 4j7xB-2je1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 8 LEU A  95
VAL A 135
LEU A 139
ILE A 106
 None
 0.87A 4r38D-2je1A:
undetectable		 4r38D-2je1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 4 TYR A 131
GLY A  97
SER A  96
LEU A 120
 None
 1.41A 5bphC-2je1A:
undetectable		 5bphC-2je1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		5 / 12 ILE A 100
VAL A 135
LEU A  95
LEU A 109
LEU A  93
 None
 1.18A 5tiwA-2je1A:
undetectable		 5tiwA-2je1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens) 		4 / 6 LEU A 142
GLN A 141
LEU A 112
LEU A 109
 None
 1.18A 5yvnA-2je1A:
undetectable		 5yvnA-2je1A:
21.31