SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jeo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		4 / 6 MET A  97
VAL A 135
LEU A  25
PHE A 152
 None
 0.98A 1x8vA-2jeoA:
undetectable		 1x8vA-2jeoA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		5 / 10 LEU A 136
VAL A  28
GLY A  27
GLY A 139
GLN A  64
 None
 1.22A 2wd9C-2jeoA:
undetectable		 2wd9C-2jeoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  25
VAL A 135
VAL A 110
VAL A 129
 None
 0.94A 2z97A-2jeoA:
undetectable		 2z97A-2jeoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		4 / 5 ASP A  65
ILE A  61
VAL A  28
THR A 160
 None
 1.10A 3eigA-2jeoA:
2.2		 3eigA-2jeoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		4 / 5 GLN A  64
PHE A 137
LYS A  36
ARG A 155
 None
 1.12A 3sufD-2jeoA:
0.0		 3sufD-2jeoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		4 / 7 SER A  37
ARG A  66
SER A  63
GLU A 138
 None
 1.40A 4xzkA-2jeoA:
undetectable		 4xzkA-2jeoA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		5 / 8 ILE A 209
VAL A 135
ILE A 104
ILE A 148
PHE A 143
 None
 1.40A 5hi2A-2jeoA:
undetectable		 5hi2A-2jeoA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		3 / 3 LEU A  47
LEU A 231
ARG A  55
 None
 0.63A 5hnzB-2jeoA:
undetectable		 5hnzB-2jeoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2jeo URIDINE-CYTIDINE
KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 231
ASN A  50
LEU A 136
 None
 0.68A 6exiA-2jeoA:
undetectable		 6exiA-2jeoA:
14.04