SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 7 ASP A  96
TRP A 119
TYR A 127
ARG A  34
 AGT  A 357 ( 3.3A)
AGT  A 357 ( 3.9A)
None
None
 1.44A 1cebB-2jerA:
undetectable		 1cebB-2jerA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		5 / 12 GLY A  98
ASN A 216
SER A 178
GLY A 121
ASN A 117
 None
 1.18A 1q8jB-2jerA:
undetectable		 1q8jB-2jerA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		5 / 11 SER A 178
THR A 215
GLY A 217
HIS A 218
PHE A 161
 None
AGT  A 357 ( 4.3A)
None
None
None
 1.48A 2hmaA-2jerA:
undetectable		 2hmaA-2jerA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		5 / 12 ASN A 354
ASN A  37
VAL A  52
ALA A  53
VAL A  94
 None
AGT  A 357 ( 4.6A)
None
None
None
 1.27A 2nniA-2jerA:
undetectable		 2nniA-2jerA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 6 GLY A 351
GLU A 214
GLY A 353
ASN A  37
 None
AGT  A 357 ( 3.8A)
AGT  A 357 ( 3.8A)
AGT  A 357 ( 4.6A)
 0.93A 3e9rA-2jerA:
undetectable		 3e9rA-2jerA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 6 GLY A 351
GLU A 214
GLY A 353
ASN A  37
 None
AGT  A 357 ( 3.8A)
AGT  A 357 ( 3.8A)
AGT  A 357 ( 4.6A)
 0.94A 3e9rC-2jerA:
undetectable		 3e9rC-2jerA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		5 / 12 ASP A 221
ASP A 220
VAL A 314
ALA A 327
ILE A 355
 AGT  A 357 ( 4.9A)
AGT  A 357 ( 3.8A)
None
None
None
 1.19A 3n3iA-2jerA:
undetectable		 3n3iA-2jerA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 VAL A   6
GLY A   7
TYR A 149
ASP A  13
 None
 1.36A 3w9tB-2jerA:
undetectable		 3w9tB-2jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 VAL A   6
GLY A   7
TYR A 149
ASP A  13
 None
 1.36A 3w9tC-2jerA:
undetectable		 3w9tC-2jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 VAL A   6
GLY A   7
TYR A 149
ASP A  13
 None
 1.35A 3w9tD-2jerA:
undetectable		 3w9tD-2jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 VAL A   6
GLY A   7
TYR A 149
ASP A  13
 None
 1.36A 3w9tE-2jerA:
undetectable		 3w9tE-2jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 VAL A   6
GLY A   7
TYR A 149
ASP A  13
 None
 1.36A 3w9tG-2jerA:
undetectable		 3w9tG-2jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 6 LEU A 198
LEU A 194
ILE A 190
THR A 171
 None
 0.98A 4do3B-2jerA:
undetectable		 4do3B-2jerA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 ASP A 124
ASP A  96
ASN A 216
CYH A 175
 None
AGT  A 357 ( 3.3A)
None
None
 1.10A 4feuF-2jerA:
undetectable		 4feuF-2jerA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 ASP A 124
ASP A  96
ASN A 216
CYH A 175
 None
AGT  A 357 ( 3.3A)
None
None
 1.10A 4fewD-2jerA:
undetectable		 4fewD-2jerA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 ASP A 124
ASP A  96
ASN A 216
CYH A 175
 None
AGT  A 357 ( 3.3A)
None
None
 1.13A 4fewF-2jerA:
undetectable		 4fewF-2jerA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 ASP A 124
ASP A  96
ASN A 216
CYH A 175
 None
AGT  A 357 ( 3.3A)
None
None
 1.11A 4gkhB-2jerA:
undetectable		 4gkhB-2jerA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 ASP A 124
ASP A  96
ASN A 216
CYH A 175
 None
AGT  A 357 ( 3.3A)
None
None
 1.11A 4gkiA-2jerA:
undetectable		 4gkiA-2jerA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 ASP A 124
ASP A  96
ASN A 216
CYH A 175
 None
AGT  A 357 ( 3.3A)
None
None
 1.11A 4gkiC-2jerA:
undetectable		 4gkiC-2jerA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		3 / 3 ASP A  91
TYR A 127
TRP A  38
 None
 1.26A 4p7nA-2jerA:
undetectable		 4p7nA-2jerA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		3 / 3 ARG A  16
GLN A 166
GLU A  22
 None
 0.78A 4tvtA-2jerA:
undetectable		 4tvtA-2jerA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 SER A 303
ALA A 223
ALA A 250
ALA A 246
 None
 0.79A 4twdF-2jerA:
undetectable
4twdG-2jerA:
undetectable
4twdH-2jerA:
undetectable
4twdI-2jerA:
undetectable
4twdJ-2jerA:
undetectable		 4twdF-2jerA:
21.81
4twdG-2jerA:
21.81
4twdH-2jerA:
21.81
4twdI-2jerA:
21.81
4twdJ-2jerA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 ASP A 286
GLY A  41
PRO A  35
TRP A  38
 None
 1.20A 5nn8A-2jerA:
undetectable		 5nn8A-2jerA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 8 PRO A 317
TYR A 319
VAL A 349
GLY A 353
 None
None
None
AGT  A 357 ( 3.8A)
 0.86A 5nzyA-2jerA:
undetectable		 5nzyA-2jerA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B2W_A_AG2A401_1
(PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		6 / 10 ASP A  91
TRP A  93
ASP A  96
TRP A 119
THR A 215
HIS A 218
 None
AGT  A 357 ( 3.4A)
AGT  A 357 ( 3.3A)
AGT  A 357 ( 3.9A)
AGT  A 357 ( 4.3A)
None
 0.55A 6b2wA-2jerA:
43.7		 6b2wA-2jerA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B2W_A_AG2A401_1
(PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		5 / 10 ASP A 133
ASP A  96
TRP A 119
THR A 215
HIS A 218
 None
AGT  A 357 ( 3.3A)
AGT  A 357 ( 3.9A)
AGT  A 357 ( 4.3A)
None
 1.35A 6b2wA-2jerA:
43.7		 6b2wA-2jerA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 GLN A 360
VAL A  27
TRP A  28
PRO A  99
 None
 1.35A 6cduA-2jerA:
undetectable
6cduB-2jerA:
undetectable		 6cduA-2jerA:
23.47
6cduB-2jerA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 5 GLN A 360
VAL A  27
PRO A  99
THR A  83
 None
 1.47A 6cduI-2jerA:
undetectable
6cduJ-2jerA:
undetectable		 6cduI-2jerA:
23.47
6cduJ-2jerA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 6 ASP A 152
TYR A 197
ASP A 113
CYH A 141
 None
 1.48A 6mn5C-2jerA:
undetectable		 6mn5C-2jerA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 6 ASP A 152
ARG A 150
ASP A 113
CYH A 141
 None
 1.20A 6mn5D-2jerA:
undetectable		 6mn5D-2jerA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2jer AGMATINE DEIMINASE
(Enterococcus
faecalis) 		4 / 7 ASP A 152
ARG A 150
ASP A 113
CYH A 141
 None
 1.26A 6mn5E-2jerA:
undetectable		 6mn5E-2jerA:
12.53