SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 8 HIS B  57
SER C 217
SER C 195
VAL C 213
GLY C 226
 None
 1.03A 1aq7A-2jetB:
14.1		 1aq7A-2jetB:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 9 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.57A 1bcuH-2jetC:
8.3		 1bcuH-2jetC:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 VAL B  52
LEU B 106
ILE C 212
GLY C 197
LEU B  33
 None
 1.01A 1eqhA-2jetB:
undetectable		 1eqhA-2jetB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 VAL B  60
VAL B  52
ILE C 212
GLY C 197
LEU B  33
 None
 1.01A 1eqhA-2jetB:
undetectable		 1eqhA-2jetB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		6 / 12 HIS B  57
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.69A 1etrH-2jetB:
13.6		 1etrH-2jetB:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		4 / 6 SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.64A 1tnlA-2jetC:
9.4		 1tnlA-2jetC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		4 / 6 SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.65A 2otvA-2jetC:
9.6		 2otvA-2jetC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		6 / 12 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 None
 0.69A 2p16A-2jetC:
10.7		 2p16A-2jetC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		4 / 8 SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.72A 2vinA-2jetC:
9.7		 2vinA-2jetC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		6 / 12 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 None
 0.60A 2w26A-2jetC:
9.2		 2w26A-2jetC:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 11 HIS B  57
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
 0.64A 3gy3A-2jetB:
14.4		 3gy3A-2jetB:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 THR B 138
THR B 139
ALA C 158
GLY C 196
SER C 217
 None
 1.17A 3mg02-2jetB:
undetectable
3mg0V-2jetB:
undetectable		 3mg02-2jetB:
19.10
3mg0V-2jetB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 THR B 104
GLY C 197
GLY B  43
VAL C 213
SER C 229
 None
 1.04A 3nk7A-2jetB:
undetectable		 3nk7A-2jetB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 6 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.61A 3rxfA-2jetC:
7.7		 3rxfA-2jetC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		4 / 5 SER C 217
SER C 195
VAL C 213
GLY C 226
 None
 1.07A 3rxhA-2jetC:
9.6		 3rxhA-2jetC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 GLY B  19
ASP B  21
GLY B 142
LYS C 154
ASP B  72
 None
 1.11A 3sueC-2jetB:
4.5		 3sueC-2jetB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 8 GLY C 197
GLY C 196
ILE B 103
LEU B 105
VAL C 231
 None
 1.01A 3v1nA-2jetC:
undetectable		 3v1nA-2jetC:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 8 ILE B 103
ASP B 102
ILE C 212
GLY B  44
 None
 0.83A 4ac9C-2jetB:
2.4		 4ac9C-2jetB:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 SER C 217
THR B 138
THR B 139
ALA C 158
GLY C 196
 None
 1.18A 4qvnV-2jetC:
undetectable
4qvnb-2jetC:
undetectable		 4qvnV-2jetC:
18.97
4qvnb-2jetC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 SER C 217
THR B 138
THR B 139
ALA C 158
GLY C 196
 None
 1.18A 4qvnH-2jetC:
undetectable
4qvnN-2jetC:
undetectable		 4qvnH-2jetC:
18.97
4qvnN-2jetC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 12 HIS B  57
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.68A 4rn6B-2jetB:
12.9		 4rn6B-2jetB:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 8 LEU C 199
GLY C 211
VAL C 200
ALA B 137
GLY C 193
 None
 1.16A 4zauA-2jetC:
undetectable		 4zauA-2jetC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus) 		5 / 8 LEU C 199
VAL C 200
ALA B 137
LEU C 160
GLY C 193
 None
 1.13A 4zauA-2jetC:
undetectable		 4zauA-2jetC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 SER C 214
SER C 195
PHE B  94
 None
 0.95A 5mugA-2jetC:
undetectable		 5mugA-2jetC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		6 / 7 GLY B 142
GLY C 193
GLY C 197
PRO C 198
GLY B  44
GLY B  43
 None
 1.20A 6ag0A-2jetB:
undetectable		 6ag0A-2jetB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 SER C 217
THR B 138
THR B 139
ALA C 158
GLY C 196
 None
 1.19A 6hwdV-2jetC:
undetectable
6hwdb-2jetC:
undetectable		 6hwdV-2jetC:
22.86
6hwdb-2jetC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 SER C 217
THR B 138
THR B 139
ALA C 158
GLY C 196
 None
 1.19A 6hwdH-2jetC:
undetectable
6hwdN-2jetC:
undetectable		 6hwdH-2jetC:
22.86
6hwdN-2jetC:
20.00