SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 VAL A 459
VAL A 411
TRP A 458
 None
 0.97A 1bdwA-2jf4A:
undetectable
1bdwB-2jf4A:
undetectable		 1bdwA-2jf4A:
3.75
1bdwB-2jf4A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 LEU A 168
SER A 161
ASN A 183
 None
 0.73A 1bx4A-2jf4A:
undetectable		 1bx4A-2jf4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 1jffB-2jf4A:
undetectable		 1jffB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 TYR A 202
GLU A 155
ASP A 160
ALA A 307
LEU A 337
 VDM  A1548 (-4.5A)
None
VDM  A1548 (-3.0A)
VDM  A1548 (-3.5A)
None
 1.31A 1nw3A-2jf4A:
undetectable		 1nw3A-2jf4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 GLY A 244
ASP A 243
ASN A 247
 None
 0.54A 1vq1A-2jf4A:
undetectable		 1vq1A-2jf4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 8 SER A 315
SER A 314
GLN A 446
TRP A 311
 None
None
VDM  A1548 (-4.2A)
None
 1.13A 2cmlC-2jf4A:
undetectable		 2cmlC-2jf4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 2hxfB-2jf4A:
undetectable		 2hxfB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 2hxhB-2jf4A:
undetectable		 2hxhB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 ARG A 273
ASP A 274
THR A 275
ASP A  41
 None
 1.09A 2j2pE-2jf4A:
undetectable
2j2pF-2jf4A:
undetectable		 2j2pE-2jf4A:
18.50
2j2pF-2jf4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 2p4nB-2jf4A:
undetectable		 2p4nB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 LEU A  73
PRO A  72
LEU A  76
 None
 0.60A 2po5B-2jf4A:
undetectable		 2po5B-2jf4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 7 TYR A 202
TYR A 157
GLN A 207
ARG A 205
 VDM  A1548 (-4.5A)
VDM  A1548 (-3.7A)
VDM  A1548 (-3.3A)
VDM  A1548 (-3.8A)
 1.50A 2qmqA-2jf4A:
0.0		 2qmqA-2jf4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 9 PHE A 211
ALA A 212
VAL A 215
GLU A 216
 None
 0.42A 2vufA-2jf4A:
undetectable		 2vufA-2jf4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 2wbeB-2jf4A:
undetectable		 2wbeB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 7 ASP A 271
SER A 204
SER A 200
ASP A  65
 None
 1.17A 3bc9A-2jf4A:
undetectable		 3bc9A-2jf4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 5 ILE A 375
SER A 339
PRO A 408
PHE A 407
 None
 1.35A 3bjwC-2jf4A:
undetectable		 3bjwC-2jf4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 9 PRO A 450
VAL A 500
GLY A 434
ILE A 476
GLY A 452
 None
 1.34A 3csjB-2jf4A:
undetectable		 3csjB-2jf4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.97A 3dcoB-2jf4A:
undetectable		 3dcoB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.98A 3edlB-2jf4A:
undetectable		 3edlB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 ASN A  69
ASP A  78
GLN A  82
 None
 0.68A 3eeyC-2jf4A:
undetectable		 3eeyC-2jf4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 ASN A  69
ASP A  78
GLN A  82
 None
 0.70A 3eeyD-2jf4A:
undetectable		 3eeyD-2jf4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 ASN A  69
ASP A  78
GLN A  82
 None
 0.66A 3eeyE-2jf4A:
undetectable		 3eeyE-2jf4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.95A 3iz0B-2jf4A:
undetectable		 3iz0B-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 12 ASP A 160
PHE A 407
THR A 402
PRO A 208
GLY A 310
 VDM  A1548 (-3.0A)
None
None
None
VDM  A1548 (-3.7A)
 0.98A 3j6pB-2jf4A:
undetectable		 3j6pB-2jf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 7 TYR A 269
LEU A 379
PHE A 407
VAL A 459
 None
 0.88A 3jwqC-2jf4A:
undetectable		 3jwqC-2jf4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 8 ASN A 522
THR A 525
LEU A 529
HIS A 118
 None
 0.94A 3kp2A-2jf4A:
undetectable
3kp2B-2jf4A:
undetectable		 3kp2A-2jf4A:
14.82
3kp2B-2jf4A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 PHE A 480
TYR A 498
THR A 525
VAL A 524
 None
 1.20A 3lb3A-2jf4A:
undetectable		 3lb3A-2jf4A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 PHE A 480
TYR A 498
THR A 525
VAL A 524
 None
 1.25A 3lb3B-2jf4A:
undetectable		 3lb3B-2jf4A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 8 LEU A 456
ALA A 449
THR A 439
TRP A 311
GLY A 310
 None
None
None
None
VDM  A1548 (-3.7A)
 1.10A 3ny4A-2jf4A:
undetectable		 3ny4A-2jf4A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 8 ALA A  54
VAL A  51
ASP A  50
LEU A  47
 None
 0.74A 3roxA-2jf4A:
undetectable		 3roxA-2jf4A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 5 ASP A 160
GLU A 496
TYR A 157
GLN A 207
 VDM  A1548 (-3.0A)
None
VDM  A1548 (-3.7A)
VDM  A1548 (-3.3A)
 1.02A 3w9tB-2jf4A:
undetectable		 3w9tB-2jf4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 5 ASP A 160
GLU A 496
TYR A 157
GLN A 207
 VDM  A1548 (-3.0A)
None
VDM  A1548 (-3.7A)
VDM  A1548 (-3.3A)
 1.10A 3w9tD-2jf4A:
undetectable		 3w9tD-2jf4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 7 PHE A  63
GLY A  45
ILE A  75
PHE A  98
 None
 0.89A 4ejjD-2jf4A:
undetectable		 4ejjD-2jf4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 7 THR A 439
VAL A 500
PRO A 450
GLY A 508
 None
 0.85A 4forA-2jf4A:
undetectable		 4forA-2jf4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 ASP A  59
TRP A 453
SER A 280
 None
None
VDM  A1548 (-3.5A)
 0.90A 4lrhA-2jf4A:
undetectable		 4lrhA-2jf4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 4 ASN A 196
GLY A 197
ASP A 516
ASP A 160
 VDM  A1548 (-2.9A)
None
None
VDM  A1548 (-3.0A)
 1.39A 4n49A-2jf4A:
undetectable		 4n49A-2jf4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 TYR A 467
ASN A 420
GLU A 376
TYR A 387
 None
 1.27A 4twdB-2jf4A:
undetectable
4twdC-2jf4A:
undetectable		 4twdB-2jf4A:
20.00
4twdC-2jf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 5 TYR A 467
ASN A 420
GLU A 376
TYR A 387
 None
 1.28A 4twdC-2jf4A:
1.9
4twdD-2jf4A:
1.9		 4twdC-2jf4A:
20.00
4twdD-2jf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 TYR A 467
ASN A 420
GLU A 376
TYR A 387
 None
 1.27A 4twdD-2jf4A:
undetectable
4twdE-2jf4A:
undetectable		 4twdD-2jf4A:
20.00
4twdE-2jf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 TYR A 467
ASN A 420
GLU A 376
TYR A 387
 None
 1.25A 4twdG-2jf4A:
undetectable
4twdH-2jf4A:
undetectable		 4twdG-2jf4A:
20.00
4twdH-2jf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 6 TYR A 467
ASN A 420
GLU A 376
TYR A 387
 None
 1.26A 4twdI-2jf4A:
undetectable
4twdJ-2jf4A:
undetectable		 4twdI-2jf4A:
20.00
4twdJ-2jf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 7 SER A 309
TRP A 447
ASP A 448
THR A 402
 None
VDM  A1548 (-4.1A)
None
None
 1.12A 4uacA-2jf4A:
undetectable		 4uacA-2jf4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 ARG A 371
TYR A 238
GLU A 345
 None
 0.58A 4zzbE-2jf4A:
undetectable		 4zzbE-2jf4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 ASP A  65
ARG A 273
ARG A 205
 None
None
VDM  A1548 (-3.8A)
 0.98A 5eajB-2jf4A:
undetectable		 5eajB-2jf4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		3 / 3 VAL A 411
ARG A 268
PRO A 334
 None
 0.73A 5koxA-2jf4A:
undetectable		 5koxA-2jf4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 10 ARG A 154
PHE A 153
GLY A 517
PHE A 518
ASN A 522
 None
VDM  A1548 (-3.8A)
None
VDM  A1548 (-4.6A)
None
 1.43A 5x66D-2jf4A:
undetectable		 5x66D-2jf4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		5 / 10 GLY A 197
TYR A 157
ASP A  65
GLU A 283
TYR A 512
 None
VDM  A1548 (-3.7A)
None
None
VDM  A1548 (-4.4A)
 1.05A 6cgdA-2jf4A:
0.6		 6cgdA-2jf4A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2jf4 PERIPLASMIC
TREHALASE
(Escherichia
coli) 		4 / 5 GLY A 121
LEU A 122
TYR A 488
GLN A 113
 None
 1.32A 6ji6A-2jf4A:
undetectable		 6ji6A-2jf4A:
17.42