SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 7 LEU A 361
ARG A 321
ASP A 366
LEU A 317
None
0.84A 1n13D-2jf7A:
undetectable
1n13E-2jf7A:
undetectable
1n13D-2jf7A:
11.93
1n13E-2jf7A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 7 PHE A 175
GLU A 169
LEU A 164
TYR A 172
None
1.21A 1rmtB-2jf7A:
1.8
1rmtB-2jf7A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 7 TYR A 441
HIS A 445
LEU A 396
TYR A 345
None
1.17A 1tuvA-2jf7A:
undetectable
1tuvA-2jf7A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 3 GLU A 331
GLU A 254
LEU A 305
None
0.65A 1v8bB-2jf7A:
undetectable
1v8bB-2jf7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 GLY A 127
GLY A 126
GLY A 132
PHE A 184
SER A 121
None
1.22A 1wg8A-2jf7A:
undetectable
1wg8A-2jf7A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 7 ASP A 338
ILE A 199
PHE A 192
GLN A 264
None
1.11A 2jc9A-2jf7A:
2.4
2jc9A-2jf7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 5 LEU A 164
PRO A 165
LEU A 168
ILE A 180
None
0.83A 2qd4A-2jf7A:
undetectable
2qd4A-2jf7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 11 ASN A 206
GLU A 207
TYR A 345
GLU A 416
TRP A 465
None
0.68A 2v3dB-2jf7A:
2.6
2v3dB-2jf7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 10 VAL A 486
ILE A  93
LEU A 111
GLY A  52
ALA A  51
None
1.22A 2xf3A-2jf7A:
undetectable
2xf3A-2jf7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 VAL A 486
ILE A  93
LEU A 111
GLY A  52
ALA A  51
None
1.24A 2xf3B-2jf7A:
undetectable
2xf3B-2jf7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 VAL A 486
ILE A  93
LEU A 111
GLY A  52
ALA A  51
None
1.21A 2xfsB-2jf7A:
undetectable
2xfsB-2jf7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 VAL A 486
ILE A  93
LEU A 111
GLY A  52
ALA A  51
None
1.26A 2xh9B-2jf7A:
undetectable
2xh9B-2jf7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 LEU A 305
THR A 306
THR A 203
THR A 204
ILE A 268
None
1.08A 3a35A-2jf7A:
undetectable
3a35A-2jf7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 LEU A 305
THR A 306
THR A 203
THR A 204
ILE A 268
None
1.10A 3a35B-2jf7A:
undetectable
3a35B-2jf7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 LEU A 305
THR A 306
THR A 203
THR A 204
ILE A 268
None
1.14A 3a3bA-2jf7A:
undetectable
3a3bA-2jf7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ATT_A_ACTA1209_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 4 ASP A 183
ARG A 128
ASP A 182
GLU A 186
None
1.35A 3attA-2jf7A:
0.0
3attA-2jf7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 4 GLY A 215
GLY A 219
GLY A 226
GLY A 224
None
0.57A 3bogC-2jf7A:
undetectable
3bogC-2jf7A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 4 GLY A 215
GLY A 219
GLY A 226
GLY A 224
None
0.48A 3bogD-2jf7A:
undetectable
3bogD-2jf7A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 7 PHE A  43
PHE A  49
TYR A 462
GLY A 341
None
1.06A 3em0B-2jf7A:
undetectable
3em0B-2jf7A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 3 TYR A 407
TYR A 337
ILE A 340
None
0.78A 3eteA-2jf7A:
undetectable
3eteB-2jf7A:
undetectable
3eteA-2jf7A:
22.20
3eteB-2jf7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 6 ILE A 340
HIS A 249
PRO A 208
LEU A 272
None
0.99A 3oi8A-2jf7A:
undetectable
3oi8A-2jf7A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 5 PHE A 195
ILE A 118
GLY A 137
HIS A 142
None
1.26A 3r0lD-2jf7A:
undetectable
3r0lD-2jf7A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 4 SER A 121
GLY A  89
GLU A 472
None
0.51A 3raeA-2jf7A:
undetectable
3raeC-2jf7A:
undetectable
3raeA-2jf7A:
23.96
3raeC-2jf7A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 6 TYR A 413
VAL A 411
THR A 203
THR A 204
None
1.05A 3tneA-2jf7A:
undetectable
3tneA-2jf7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 7 TYR A 477
GLU A  59
GLN A  91
TYR A  96
None
1.26A 3ugrA-2jf7A:
10.3
3ugrA-2jf7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 3 TYR A 402
ASP A 295
ASP A 288
None
0.60A 4a6eA-2jf7A:
undetectable
4a6eA-2jf7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 GLY A  60
ALA A  92
SER A 117
TYR A 114
PHE A 144
None
1.40A 4bupA-2jf7A:
undetectable
4bupA-2jf7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 4 LEU A 164
PRO A 165
LEU A 168
ILE A 180
None
0.91A 4f4dB-2jf7A:
undetectable
4f4dB-2jf7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 4 SER A 121
GLY A  89
GLU A 472
None
0.56A 4juoA-2jf7A:
undetectable
4juoC-2jf7A:
undetectable
4juoA-2jf7A:
23.96
4juoC-2jf7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 3 HIS A 442
GLY A 482
ILE A 483
None
0.57A 4k50A-2jf7A:
undetectable
4k50A-2jf7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 3 HIS A 442
GLY A 482
ILE A 483
None
0.56A 4k50I-2jf7A:
undetectable
4k50I-2jf7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 PHE A 205
PRO A 208
ASN A 273
MET A 342
LEU A 246
None
1.27A 4kowA-2jf7A:
0.9
4kowA-2jf7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 6 TYR A 402
LEU A 272
VAL A 213
ALA A 212
None
0.79A 4nkvC-2jf7A:
undetectable
4nkvC-2jf7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 6 LEU A 272
ASN A 343
LEU A 412
VAL A 449
None
1.19A 4okbA-2jf7A:
undetectable
4okbA-2jf7A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 12 TYR A 187
ILE A 270
ALA A 188
HIS A 161
ILE A 245
None
1.11A 4rvdA-2jf7A:
undetectable
4rvdA-2jf7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
3 / 3 ASN A 206
PHE A 463
TYR A 114
None
0.69A 4u15A-2jf7A:
undetectable
4u15A-2jf7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 TYR A 385
GLY A 386
GLY A 387
VAL A 420
HIS A 390
None
1.37A 5f8yA-2jf7A:
undetectable
5f8yA-2jf7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 TYR A 385
GLY A 386
GLY A 387
VAL A 420
HIS A 390
None
1.32A 5f8yA-2jf7A:
undetectable
5f8yA-2jf7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 TYR A 385
GLY A 386
GLY A 387
VAL A 420
HIS A 390
None
1.34A 5f8yB-2jf7A:
undetectable
5f8yB-2jf7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
5 / 9 TYR A 385
GLY A 386
GLY A 387
VAL A 420
HIS A 390
None
1.36A 5f8yB-2jf7A:
undetectable
5f8yB-2jf7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina)
4 / 6 ASP A 469
ASN A 474
ASN A 470
GLN A  57
None
1.18A 5l6eA-2jf7A:
undetectable
5l6eA-2jf7A:
17.37