SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 8 ARG A 633
LEU A 665
ALA A 621
GLY A 653
VAL A 662
 None
 1.33A 1d4sB-2jfdA:
undetectable		 1d4sB-2jfdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 805
LEU A 438
VAL A 472
GLY A 478
ALA A 798
 None
 1.25A 1e7aA-2jfdA:
1.7		 1e7aA-2jfdA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 8 ALA A 426
LEU A 423
LEU A 424
LEU A 438
ALA A 471
 None
 1.24A 1e7cA-2jfdA:
undetectable		 1e7cA-2jfdA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 796
THR A 780
VAL A 757
LEU A 567
ILE A 800
 None
 1.30A 1kqwA-2jfdA:
undetectable		 1kqwA-2jfdA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 ASP A 591
GLY A 592
PRO A 707
SER A 730
 None
 0.85A 1n4fA-2jfdA:
undetectable		 1n4fA-2jfdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 791
LYS A 419
ARG A 422
 None
 1.15A 1ra8A-2jfdA:
undetectable		 1ra8A-2jfdA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 PHE A 516
LEU A 563
ILE A 564
SER A 519
 None
 1.14A 1sbrA-2jfdA:
2.2
1sbrB-2jfdA:
2.1		 1sbrA-2jfdA:
19.17
1sbrB-2jfdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 566
LEU A 803
LEU A 797
ILE A 782
 None
 0.95A 1z95A-2jfdA:
undetectable		 1z95A-2jfdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.30A 2nmzA-2jfdA:
undetectable		 2nmzA-2jfdA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.32A 2rkfB-2jfdA:
undetectable		 2rkfB-2jfdA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 8 ARG A 425
ILE A 800
ASP A 791
LEU A 793
PHE A 796
 None
 1.36A 2tsrB-2jfdA:
undetectable		 2tsrB-2jfdA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 PHE A 553
SER A 714
PHE A 682
ILE A 717
 None
 1.16A 2v0mD-2jfdA:
undetectable		 2v0mD-2jfdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 553
GLY A 498
GLY A 500
SER A 552
SER A 581
 None
 1.40A 3dlcA-2jfdA:
undetectable		 3dlcA-2jfdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.30A 3jw2A-2jfdA:
undetectable		 3jw2A-2jfdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.31A 3jw2B-2jfdA:
undetectable		 3jw2B-2jfdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.13A 3kvvA-2jfdA:
undetectable		 3kvvA-2jfdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.10A 3kvvB-2jfdA:
undetectable		 3kvvB-2jfdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.10A 3kvvC-2jfdA:
undetectable		 3kvvC-2jfdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.07A 3kvvD-2jfdA:
undetectable		 3kvvD-2jfdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.09A 3kvvE-2jfdA:
undetectable		 3kvvE-2jfdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.13A 3kvvF-2jfdA:
undetectable		 3kvvF-2jfdA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.25A 3s54B-2jfdA:
undetectable		 3s54B-2jfdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 THR A 715
VAL A 578
GLU A 747
LEU A 775
VAL A 770
 None
 1.23A 3tbgC-2jfdA:
undetectable		 3tbgC-2jfdA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 10 ALA A 590
ASP A 591
GLY A 579
ILE A 495
LEU A 563
ILE A 564
 None
 1.16A 3ttpA-2jfdA:
undetectable		 3ttpA-2jfdA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 10 ALA A 590
ASP A 591
GLY A 579
ILE A 495
LEU A 563
ILE A 564
 None
 1.14A 3ttpB-2jfdA:
undetectable		 3ttpB-2jfdA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 579
MET A 499
ILE A 495
VAL A 578
 None
 1.12A 4e1vF-2jfdA:
undetectable		 4e1vF-2jfdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 GLY A 428
SER A 427
ALA A 426
PHE A 467
 None
 1.05A 4m93B-2jfdA:
undetectable
4m93C-2jfdA:
undetectable		 4m93B-2jfdA:
20.09
4m93C-2jfdA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 ALA A 599
ILE A 564
GLY A 562
ILE A 520
VAL A 585
 None
 1.13A 4nptA-2jfdA:
undetectable		 4nptA-2jfdA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 807
ALA A 462
ARG A 468
LEU A 492
ALA A 810
 None
 1.19A 5bw4B-2jfdA:
undetectable		 5bw4B-2jfdA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.23A 5e5kA-2jfdA:
undetectable		 5e5kA-2jfdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.27A 5t2zB-2jfdA:
undetectable		 5t2zB-2jfdA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 567
ALA A 590
ILE A 561
GLY A 583
ILE A 564
 None
 0.89A 5t8hB-2jfdA:
undetectable		 5t8hB-2jfdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A 793
PHE A 795
LEU A 510
PHE A 516
 None
 1.25A 5xdxP-2jfdA:
undetectable
5xdxW-2jfdA:
undetectable		 5xdxP-2jfdA:
21.13
5xdxW-2jfdA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2jfd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 LEU A 513
LEU A 793
ARG A 512
 None
 0.67A 6fgdA-2jfdA:
undetectable		 6fgdA-2jfdA:
21.31