SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		5 / 10 GLY X 187
ASP X 175
LEU X 176
VAL X 171
ALA X 330
 None
 1.28A 1fpqA-2jfeX:
undetectable		 1fpqA-2jfeX:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 ASP X 105
LEU X 108
LYS X 109
ARG X 156
 None
 1.31A 2gj5A-2jfeX:
undetectable		 2gj5A-2jfeX:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 PHE X  91
ARG X  82
GLY X  26
LYS X  27
 None
 0.88A 2i30A-2jfeX:
undetectable		 2i30A-2jfeX:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 LEU X 123
PRO X 124
LEU X 127
ILE X 138
 None
 0.63A 2qd4A-2jfeX:
undetectable		 2qd4A-2jfeX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 TYR X 174
TYR X 119
LEU X 127
TRP X  80
 None
 1.38A 3uzzB-2jfeX:
9.5		 3uzzB-2jfeX:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 ARG X  75
TYR X 309
VAL X 168
ASN X 164
HIS X 120
 None
 1.50A 3w2tB-2jfeX:
undetectable		 3w2tB-2jfeX:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		5 / 12 VAL X 349
GLY X 352
HIS X 250
ARG X 312
PRO X 336
 None
 1.40A 4bvaB-2jfeX:
undetectable		 4bvaB-2jfeX:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 GLY X  20
ASP X  50
GLY X  49
HIS X  37
 None
 0.91A 4c5nA-2jfeX:
3.4		 4c5nA-2jfeX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 GLY X  20
ASP X  50
GLY X  49
HIS X  37
 None
 0.84A 4c5nC-2jfeX:
3.5		 4c5nC-2jfeX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 4 LEU X 123
PRO X 124
LEU X 127
ILE X 138
 None
 0.75A 4f4dB-2jfeX:
undetectable		 4f4dB-2jfeX:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		5 / 9 ARG X 285
GLY X 325
PHE X 249
GLY X 187
ASP X 175
 None
 1.36A 4h2gA-2jfeX:
undetectable		 4h2gA-2jfeX:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 8 PRO X 350
VAL X 349
PRO X 336
ILE X 341
 None
 1.07A 4iilA-2jfeX:
undetectable		 4iilA-2jfeX:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 5 ILE X  66
HIS X 120
TYR X 370
VAL X 413
 None
 1.34A 4s0vA-2jfeX:
undetectable		 4s0vA-2jfeX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 CYH X 415
ILE X 371
GLN X 307
ILE X 115
 None
 1.13A 4w5tA-2jfeX:
undetectable		 4w5tA-2jfeX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 ASP X 407
ASN X 410
PHE X 304
 None
 0.72A 5dsgB-2jfeX:
undetectable		 5dsgB-2jfeX:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 GLU X 230
ASN X 374
ILE X 371
VAL X 353
 None
 1.16A 5jh7C-2jfeX:
2.6		 5jh7C-2jfeX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		3 / 3 ASP X 302
ASN X 410
GLN X 412
 None
 0.79A 5k7uA-2jfeX:
undetectable		 5k7uA-2jfeX:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 ASP X 421
ASN X 426
ASN X 422
GLN X  17
 None
 1.12A 5l6eA-2jfeX:
undetectable		 5l6eA-2jfeX:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 VAL X 220
LEU X 118
LEU X 197
GLU X 165
 None
 0.76A 5tudD-2jfeX:
undetectable		 5tudD-2jfeX:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 6 CYH X 415
ILE X 371
GLN X 307
ILE X 115
 None
 1.13A 6cbdA-2jfeX:
undetectable		 6cbdA-2jfeX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens) 		4 / 7 ASP X  62
GLY X  20
SER X  55
GLY X  54
 None
 0.80A 6ekzA-2jfeX:
undetectable		 6ekzA-2jfeX:
10.93