SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 8 LEU A 187
VAL A 200
GLY A 131
LEU A 214
 None
 0.85A 1jlbA-2jfnA:
undetectable		 1jlbA-2jfnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 8 LEU A 187
VAL A 200
GLY A 131
LEU A 214
 None
 0.98A 1s1xA-2jfnA:
undetectable		 1s1xA-2jfnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 10 LEU A 168
LEU A 183
ALA A 182
LEU A 218
VAL A 217
 None
 1.16A 2bxeA-2jfnA:
undetectable		 2bxeA-2jfnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 6 ASP A 250
THR A 277
GLU A 276
GLU A 279
 None
 1.25A 2dttB-2jfnA:
undetectable
2dttC-2jfnA:
undetectable		 2dttB-2jfnA:
18.51
2dttC-2jfnA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 10 VAL A  90
VAL A  89
VAL A  79
ILE A  75
VAL A  76
 None
 0.93A 2qboA-2jfnA:
undetectable		 2qboA-2jfnA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 LEU A  25
ASP A 250
ILE A 253
ALA A  52
ILE A  50
 None
 0.86A 2rkfB-2jfnA:
undetectable		 2rkfB-2jfnA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 LEU A 187
LEU A 214
VAL A 200
ALA A 182
GLY A 161
 None
 1.05A 2vmyA-2jfnA:
undetectable		 2vmyA-2jfnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 5 TYR A  49
ILE A  40
LEU A  87
LEU A 239
 None
 1.18A 2zb7A-2jfnA:
undetectable		 2zb7A-2jfnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 ASP A  28
GLY A  32
THR A 135
LEU A 209
ALA A 169
 GLU  A1287 (-2.8A)
GLU  A1287 ( 4.2A)
GLU  A1287 ( 4.2A)
None
None
 1.09A 3d91A-2jfnA:
undetectable		 3d91A-2jfnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 8 ILE A  68
PHE A  67
THR A  77
LEU A 103
VAL A  90
 None
 1.25A 3ua5A-2jfnA:
undetectable		 3ua5A-2jfnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 4 ASN A  93
VAL A 201
THR A 144
ILE A 148
 GLU  A1287 (-4.0A)
None
None
None
 1.37A 4retA-2jfnA:
2.1		 4retA-2jfnA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 4 ASN A  93
VAL A 201
THR A 144
ILE A 148
 GLU  A1287 (-4.0A)
None
None
None
 1.37A 4retC-2jfnA:
2.3		 4retC-2jfnA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 ALA A 134
GLY A 137
GLY A  61
ILE A  68
LEU A 100
 None
None
GLU  A1287 (-3.5A)
None
UMA  A1286 (-4.4A)
 1.02A 5ul4A-2jfnA:
2.7		 5ul4A-2jfnA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		3 / 3 ARG A  21
PHE A 109
LEU A 239
 None
 0.86A 5veuA-2jfnA:
undetectable		 5veuA-2jfnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 VAL A 166
SER A 162
THR A 135
PHE A  58
GLY A  61
 None
None
GLU  A1287 ( 4.2A)
GLU  A1287 (-4.5A)
GLU  A1287 (-3.5A)
 1.02A 6drzA-2jfnA:
undetectable		 6drzA-2jfnA:
21.63