SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A  59
PHE A  56
LEU A  65
GLN A 101
GLY A 102
 None
 1.36A 1uhoA-2jftA:
undetectable		 1uhoA-2jftA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A  59
PHE A  56
LEU A  65
GLN A 101
GLY A 103
 None
 1.30A 1uhoA-2jftA:
undetectable		 1uhoA-2jftA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 127
ILE A 172
VAL A  33
 None
 0.70A 2avvD-2jftA:
undetectable		 2avvD-2jftA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 168
ASN A 108
THR A  89
 None
 0.76A 2q63B-2jftA:
undetectable		 2q63B-2jftA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PHE A  37
GLY A  41
ALA A  23
LEU A 159
THR A  47
 None
 1.21A 3a3yA-2jftA:
undetectable		 3a3yA-2jftA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASN A  19
ALA A  46
GLY A  36
THR A  85
 None
None
MG  A 301 (-4.1A)
None
 0.93A 3dl9A-2jftA:
undetectable		 3dl9A-2jftA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A  27
LEU A  30
GLN A 101
 None
 0.68A 3g4lA-2jftA:
undetectable		 3g4lA-2jftA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PRO A  15
GLY A 221
GLY A 220
ASP A  12
ASP A 218
 None
 1.00A 4b17A-2jftA:
undetectable		 4b17A-2jftA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  79
LEU A  80
SER A  87
THR A  89
 None
 1.05A 4i89A-2jftA:
undetectable		 4i89A-2jftA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 158
GLY A 110
ILE A 165
ASN A  73
GLY A 160
 None
 1.22A 4obwD-2jftA:
undetectable		 4obwD-2jftA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 8 ALA A  48
ALA A  72
ALA A  57
PHE A  56
LEU A  65
 None
 1.29A 4v1fA-2jftA:
undetectable
4v1fB-2jftA:
undetectable		 4v1fA-2jftA:
16.67
4v1fB-2jftA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 8 ALA A  48
ALA A  72
ALA A  58
PHE A  56
LEU A  65
 None
 1.31A 4v1fA-2jftA:
undetectable
4v1fB-2jftA:
undetectable		 4v1fA-2jftA:
16.67
4v1fB-2jftA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  79
LEU A  80
SER A  87
THR A  89
 None
 1.01A 5bojA-2jftA:
undetectable		 5bojA-2jftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A  17
ASP A  35
GLY A  36
ASP A  22
 SO4  A 306 (-2.8A)
MN  A 302 ( 2.6A)
MG  A 301 (-4.1A)
MN  A 302 ( 4.8A)
 1.33A 5hp1A-2jftA:
undetectable		 5hp1A-2jftA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  79
LEU A  80
SER A  87
THR A  89
 None
 1.05A 5l4iA-2jftA:
undetectable		 5l4iA-2jftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2jft SER-THR PHOSPHATASE
MSPP
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 109
VAL A  69
LEU A  66
LEU A 105
ALA A  95
 None
 1.13A 6ajiA-2jftA:
undetectable		 6ajiA-2jftA:
15.65