SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 12 LEU A 263
GLY A  18
GLY A  19
ALA A 254
LEU A 258
 None
 0.96A 1bx4A-2jfwA:
3.8		 1bx4A-2jfwA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 11 CYH A  77
ILE A  97
THR A 215
ILE A  75
VAL A  74
 TLA  A1272 ( 4.2A)
None
None
None
None
 1.20A 1pkvA-2jfwA:
undetectable
1pkvB-2jfwA:
undetectable		 1pkvA-2jfwA:
17.53
1pkvB-2jfwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 11 ILE A  75
VAL A  74
CYH A  77
ILE A  97
THR A 215
 None
None
TLA  A1272 ( 4.2A)
None
None
 1.15A 1pkvA-2jfwA:
undetectable
1pkvB-2jfwA:
undetectable		 1pkvA-2jfwA:
17.53
1pkvB-2jfwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		6 / 12 VAL A 116
ALA A 107
THR A  81
THR A 104
GLY A 187
SER A 127
 None
 1.34A 1uwjA-2jfwA:
undetectable		 1uwjA-2jfwA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 6 LEU A  73
ILE A  70
MET A  61
VAL A 155
 None
 1.14A 2ygoA-2jfwA:
undetectable		 2ygoA-2jfwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 8 ALA A  84
THR A  62
ILE A  13
THR A  58
 None
 0.90A 3bpxA-2jfwA:
undetectable
3bpxB-2jfwA:
undetectable		 3bpxA-2jfwA:
18.09
3bpxB-2jfwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 12 TYR A 191
GLY A  16
GLU A 156
VAL A  17
GLY A  18
 None
 1.23A 3f8wB-2jfwA:
undetectable		 3f8wB-2jfwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 8 PRO A  31
SER A 220
LEU A 223
ASP A 224
 None
 0.75A 3lsfH-2jfwA:
undetectable		 3lsfH-2jfwA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 8 PRO A  48
PRO A  50
GLN A  53
GLU A  52
 None
 1.13A 3oyaA-2jfwA:
2.5		 3oyaA-2jfwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 10 VAL A  99
ASN A  78
ALA A  80
THR A  58
ILE A  13
 None
TLA  A1272 (-4.3A)
None
None
None
 1.37A 3t3qC-2jfwA:
undetectable		 3t3qC-2jfwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		3 / 3 LYS A  89
ARG A 105
LEU A 222
 None
 1.24A 3v4tE-2jfwA:
undetectable		 3v4tE-2jfwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		3 / 3 THR A   5
ASN A 230
SER A 229
 None
 0.70A 4tvtA-2jfwA:
undetectable		 4tvtA-2jfwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 8 ILE A  70
TYR A  64
LEU A  36
ILE A  10
 None
 0.80A 4v04A-2jfwA:
undetectable		 4v04A-2jfwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 7 PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.85A 4zdzA-2jfwA:
undetectable		 4zdzA-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 12 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.87A 4ze2A-2jfwA:
undetectable		 4ze2A-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 4 LEU A 173
MET A 202
VAL A 201
ASN A 200
 None
 1.28A 5b8iB-2jfwA:
undetectable		 5b8iB-2jfwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 12 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.89A 5eqbA-2jfwA:
undetectable		 5eqbA-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		4 / 8 PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.90A 5esfA-2jfwA:
undetectable		 5esfA-2jfwA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 12 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.95A 5eskA-2jfwA:
undetectable		 5eskA-2jfwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 12 GLY A 217
PHE A 250
ILE A 253
PHE A  37
GLY A  16
 None
 0.95A 5eslA-2jfwA:
undetectable		 5eslA-2jfwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 11 VAL A  99
ILE A 100
TYR A 130
ILE A 185
ILE A 118
 None
 1.19A 5hw8G-2jfwA:
undetectable		 5hw8G-2jfwA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		5 / 10 PRO A   9
LEU A  73
ILE A  75
ALA A  80
VAL A  38
 None
 1.16A 5m0oA-2jfwA:
undetectable		 5m0oA-2jfwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		3 / 3 GLY A 187
THR A 121
ASN A  78
 None
TLA  A1272 (-3.9A)
TLA  A1272 (-4.3A)
 0.68A 5odiG-2jfwA:
4.3		 5odiG-2jfwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2jfw GLUTAMATE RACEMASE
(Enterococcus
faecium) 		3 / 3 GLY A 187
THR A 189
ASN A  78
 None
None
TLA  A1272 (-4.3A)
 0.53A 5odiG-2jfwA:
4.3		 5odiG-2jfwA:
19.02