SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 10 LEU A 201
ALA A 221
VAL A 230
GLN A 250
PHE A 176
 None
 1.02A 1rlbE-2jg2A:
undetectable		 1rlbE-2jg2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 10 LEU A 201
ALA A 221
VAL A 230
LEU A 252
PHE A 176
 None
 1.27A 1rlbE-2jg2A:
undetectable		 1rlbE-2jg2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 4 GLY A 203
SER A 235
VAL A 259
LEU A 214
 None
 1.05A 1yajB-2jg2A:
undetectable		 1yajB-2jg2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		3 / 3 THR A 382
PRO A 380
PRO A 383
 None
 0.87A 2d55C-2jg2A:
undetectable		 2d55C-2jg2A:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 9 PHE A 122
ARG A 120
ALA A 128
LEU A 119
ALA A 118
 None
 1.50A 2o01B-2jg2A:
undetectable		 2o01B-2jg2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 LEU A 154
VAL A 152
ASP A 231
SER A 264
ASN A 138
 None
None
PLP  A1265 (-2.8A)
PLP  A1265 (-3.1A)
PLP  A1265 (-4.2A)
 1.38A 2y00A-2jg2A:
undetectable		 2y00A-2jg2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 8 ARG A 120
GLY A 127
VAL A 275
ARG A 103
 None
 0.86A 3bgdB-2jg2A:
2.2		 3bgdB-2jg2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		6 / 10 LEU A 389
GLY A 413
ALA A 412
GLY A 407
LEU A 406
VAL A 374
 None
 1.16A 3em3A-2jg2A:
undetectable		 3em3A-2jg2A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 8 GLY A 413
ALA A 412
GLY A 407
LEU A 406
VAL A 374
 None
 0.93A 3em6A-2jg2A:
undetectable		 3em6A-2jg2A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		3 / 3 ASP A 155
LEU A 201
GLN A 250
 None
 0.77A 3g4lA-2jg2A:
undetectable		 3g4lA-2jg2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 10 ALA A  60
LEU A 368
ILE A  49
ALA A  48
VAL A  43
 None
 1.35A 3r9cA-2jg2A:
undetectable		 3r9cA-2jg2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 5 SER A 308
GLY A 243
GLU A 253
GLU A 248
 None
 1.35A 3raeB-2jg2A:
undetectable
3raeD-2jg2A:
2.0		 3raeB-2jg2A:
22.24
3raeD-2jg2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 LEU A 229
LEU A 154
GLY A 140
LEU A 139
SER A 161
 None
None
None
None
PLP  A1265 (-3.3A)
 1.32A 3tbgA-2jg2A:
undetectable		 3tbgA-2jg2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 LEU A 229
LEU A 154
GLY A 140
LEU A 139
SER A 161
 None
None
None
None
PLP  A1265 (-3.3A)
 1.30A 3tbgC-2jg2A:
undetectable		 3tbgC-2jg2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 PHE A 409
ILE A  68
LEU A  70
GLY A 370
VAL A 374
 None
 0.96A 4nkvB-2jg2A:
undetectable		 4nkvB-2jg2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		3 / 5 GLY A 237
GLY A 245
GLU A 248
 None
 0.48A 4z2eA-2jg2A:
undetectable
4z2eD-2jg2A:
undetectable		 4z2eA-2jg2A:
25.00
4z2eD-2jg2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		3 / 3 LYS A 318
ARG A 319
HIS A 316
 None
 1.06A 4zbrA-2jg2A:
undetectable		 4zbrA-2jg2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 7 SER A 296
ALA A 295
HIS A 112
PRO A 298
 None
 0.94A 5dzkD-2jg2A:
undetectable
5dzkR-2jg2A:
undetectable		 5dzkD-2jg2A:
20.19
5dzkR-2jg2A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		3 / 3 THR A 307
ALA A  87
LYS A  89
 None
 0.66A 6fgcA-2jg2A:
1.6		 6fgcA-2jg2A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2jg2 SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
paucimobilis) 		3 / 3 THR A 307
ALA A  87
LYS A  89
 None
 0.64A 6fgdA-2jg2A:
2.2		 6fgdA-2jg2A:
24.36