SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 8 ASP A 606
HIS A 646
GLY A 608
GLY A 650
 None
 0.91A 1ekjA-2jgdA:
undetectable
1ekjB-2jgdA:
undetectable		 1ekjA-2jgdA:
15.14
1ekjB-2jgdA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 7 ASP A 606
HIS A 646
GLY A 608
GLY A 650
 None
 0.93A 1ekjE-2jgdA:
4.9
1ekjF-2jgdA:
4.5		 1ekjE-2jgdA:
15.14
1ekjF-2jgdA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 8 LEU A 436
ARG A 441
PHE A 444
TRP A 183
 None
 0.81A 1fapB-2jgdA:
undetectable		 1fapB-2jgdA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 PHE A 851
LEU A 860
PHE A 869
ILE A 845
LEU A 738
 None
 1.23A 1kglA-2jgdA:
undetectable		 1kglA-2jgdA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 LEU A 271
VAL A 266
VAL A 384
LEU A 239
LEU A 438
 None
 1.28A 1mx1E-2jgdA:
undetectable		 1mx1E-2jgdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 GLY A 362
VAL A 360
MET A 414
ILE A 411
GLY A 364
 None
 1.39A 1pn0A-2jgdA:
undetectable		 1pn0A-2jgdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 GLY A 362
VAL A 360
MET A 414
ILE A 411
GLY A 364
 None
 1.40A 1pn0B-2jgdA:
undetectable		 1pn0B-2jgdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 GLY A 362
VAL A 360
MET A 414
ILE A 411
GLY A 364
 None
 1.41A 1pn0C-2jgdA:
undetectable		 1pn0C-2jgdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 GLY A 362
VAL A 360
MET A 414
ILE A 411
GLY A 364
 None
 1.40A 1pn0D-2jgdA:
undetectable		 1pn0D-2jgdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 PHE A 591
ASP A 592
ARG A 783
SER A 777
LEU A 717
 None
 1.36A 1ynnC-2jgdA:
0.0		 1ynnC-2jgdA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 8 ILE A 354
ILE A 388
ASN A 269
VAL A 270
 None
 0.71A 2nniA-2jgdA:
undetectable		 2nniA-2jgdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 LEU A 316
LEU A 267
LEU A 213
MET A 258
 None
 1.14A 2oaxF-2jgdA:
undetectable		 2oaxF-2jgdA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 4 ALA A 666
VAL A 330
PHE A 667
THR A 369
 None
 1.48A 2pkkA-2jgdA:
undetectable		 2pkkA-2jgdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 4 ALA A 666
VAL A 330
PHE A 700
THR A 673
 None
None
None
AMP  A1934 (-3.9A)
 1.30A 2pkkA-2jgdA:
undetectable		 2pkkA-2jgdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 6 ILE A 331
ARG A 385
PRO A 351
VAL A 295
 None
 0.99A 2ygoA-2jgdA:
undetectable		 2ygoA-2jgdA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 11 LEU A 766
VAL A 549
TYR A 601
TYR A 545
GLU A 607
 None
 1.45A 3bgrA-2jgdA:
0.3
3bgrB-2jgdA:
undetectable		 3bgrA-2jgdA:
20.04
3bgrB-2jgdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 9 LEU A 314
VAL A 270
LEU A 350
ILE A 352
ALA A 246
 None
 1.10A 3mdvA-2jgdA:
undetectable		 3mdvA-2jgdA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 ALA A 911
VAL A 912
GLN A 921
 None
 0.63A 3of4B-2jgdA:
undetectable		 3of4B-2jgdA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 6 VAL A 564
TYR A 578
TYR A 639
ILE A 561
 None
 1.12A 3q5sA-2jgdA:
undetectable		 3q5sA-2jgdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 7 ARG A 900
ALA A 902
TRP A 871
ALA A 929
 None
 0.85A 3tx2A-2jgdA:
2.8		 3tx2A-2jgdA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 ASP A 451
ARG A 261
THR A 409
 None
 0.75A 4i13A-2jgdA:
undetectable		 4i13A-2jgdA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 7 LEU A 613
ASN A 598
GLN A 643
LEU A 642
 None
 1.11A 4ib4A-2jgdA:
undetectable		 4ib4A-2jgdA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 GLY A 142
ALA A 145
ALA A 159
PHE A 139
MET A 151
 None
 1.24A 4kicA-2jgdA:
2.4		 4kicA-2jgdA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 LEU A 766
ARG A 767
MET A 746
 None
 0.97A 4m11C-2jgdA:
undetectable		 4m11C-2jgdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 MET A 238
LEU A 235
VAL A 270
GLY A 247
THR A 307
 None
 1.43A 4mubA-2jgdA:
undetectable		 4mubA-2jgdA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 6 LEU A 613
ASN A 598
GLN A 643
LEU A 642
 None
 1.15A 4nc3A-2jgdA:
undetectable		 4nc3A-2jgdA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 LEU A 256
LEU A 239
ILE A 236
LEU A 235
LEU A 213
 None
 0.81A 4odoA-2jgdA:
undetectable		 4odoA-2jgdA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 LEU A 256
LEU A 239
ILE A 236
LEU A 235
LEU A 213
 None
 0.86A 4odoB-2jgdA:
undetectable		 4odoB-2jgdA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 LEU A 256
LEU A 239
ILE A 236
LEU A 235
LEU A 213
 None
 0.85A 4odoC-2jgdA:
undetectable		 4odoC-2jgdA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 ASP A 451
ARG A 261
THR A 409
 None
 0.74A 4p3rA-2jgdA:
undetectable		 4p3rA-2jgdA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 ASN A 423
VAL A 422
LEU A 229
LEU A 207
ASP A 425
 None
 1.17A 4qckA-2jgdA:
undetectable		 4qckA-2jgdA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 ASP A 294
HIS A 298
LYS A 296
 None
 0.92A 4qzuD-2jgdA:
undetectable		 4qzuD-2jgdA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 LEU A 256
MET A 238
LEU A 235
HIS A 355
 None
 1.37A 4xi3B-2jgdA:
undetectable		 4xi3B-2jgdA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 7 THR A 369
LEU A 370
THR A 353
THR A 383
 None
 0.96A 4z91F-2jgdA:
undetectable
4z91G-2jgdA:
undetectable
4z91H-2jgdA:
undetectable
4z91I-2jgdA:
undetectable
4z91J-2jgdA:
undetectable		 4z91F-2jgdA:
16.22
4z91G-2jgdA:
16.22
4z91H-2jgdA:
16.22
4z91I-2jgdA:
16.22
4z91J-2jgdA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 11 ALA A 375
ASP A 617
GLU A 616
THR A 622
GLY A 621
 None
 1.48A 4zjoD-2jgdA:
undetectable		 4zjoD-2jgdA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 6 GLU A 214
GLY A 231
GLY A 232
ASP A 233
 None
 0.73A 5a06D-2jgdA:
2.1		 5a06D-2jgdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 6 GLU A 230
GLY A 231
GLY A 232
ASP A 233
 None
 1.05A 5a06D-2jgdA:
2.1		 5a06D-2jgdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 ARG A 900
ARG A 816
ASN A 931
VAL A 932
 None
 1.22A 5cshB-2jgdA:
undetectable		 5cshB-2jgdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 LEU A 642
VAL A 611
PHE A 652
TYR A 578
GLY A 594
 None
 1.41A 5i8fA-2jgdA:
undetectable		 5i8fA-2jgdA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 VAL A 748
GLN A 739
CYH A 741
 None
 0.75A 5icxA-2jgdA:
undetectable
5icxE-2jgdA:
undetectable		 5icxA-2jgdA:
12.68
5icxE-2jgdA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 VAL A 774
GLN A 739
CYH A 741
 None
 0.85A 5icxC-2jgdA:
undetectable
5icxF-2jgdA:
undetectable		 5icxC-2jgdA:
12.68
5icxF-2jgdA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 ARG A 900
ARG A 816
ASN A 931
VAL A 932
 None
 1.23A 5os7B-2jgdA:
undetectable		 5os7B-2jgdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 7 ARG A 100
TYR A 164
GLU A 189
LEU A  95
 None
 1.12A 5umwB-2jgdA:
undetectable
5umwE-2jgdA:
undetectable		 5umwB-2jgdA:
6.75
5umwE-2jgdA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW3_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 4 GLN A 831
LEU A 930
ASN A 835
GLN A 837
 None
 1.50A 5vw3A-2jgdA:
2.1		 5vw3A-2jgdA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 8 GLU A 214
HIS A 260
GLY A 232
LEU A 235
 None
 0.87A 5w3jB-2jgdA:
undetectable		 5w3jB-2jgdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 9 VAL A 664
GLY A 619
VAL A 654
ASP A 617
GLY A 621
 None
 1.28A 5zniA-2jgdA:
undetectable		 5zniA-2jgdA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 10 LEU A 714
ALA A 672
GLU A 616
SER A 618
VAL A 611
 None
 1.46A 6b89B-2jgdA:
2.4		 6b89B-2jgdA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 VAL A 254
THR A 251
LEU A 271
VAL A 520
 None
 0.95A 6bqgA-2jgdA:
undetectable		 6bqgA-2jgdA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 12 VAL A 360
VAL A 387
GLY A 382
VAL A 380
GLY A 257
 None
 1.09A 6brdC-2jgdA:
undetectable		 6brdC-2jgdA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 8 LEU A 791
LEU A 554
GLY A 594
TYR A 758
 None
 0.95A 6ce2A-2jgdA:
1.7		 6ce2A-2jgdA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 ARG A 900
ARG A 816
ASN A 931
VAL A 932
 None
 1.23A 6gmdA-2jgdA:
undetectable		 6gmdA-2jgdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 8 GLY A 594
PHE A 591
VAL A 788
ALA A 583
 None
 0.79A 6hu9H-2jgdA:
undetectable
6hu9e-2jgdA:
undetectable		 6hu9H-2jgdA:
7.10
6hu9e-2jgdA:
9.46