SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 TRP A 261
ALA A  83
VAL A  87
 None
 0.98A 1bdwA-2jgpA:
undetectable
1bdwB-2jgpA:
undetectable		 1bdwA-2jgpA:
5.16
1bdwB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 LEU A 133
VAL A 138
VAL A 240
GLN A 244
 None
 1.03A 1e7aB-2jgpA:
undetectable		 1e7aB-2jgpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  83
VAL A  87
TRP A 261
 None
 0.95A 1gmkA-2jgpA:
undetectable
1gmkB-2jgpA:
undetectable		 1gmkA-2jgpA:
5.16
1gmkB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.86A 1jnoA-2jgpA:
undetectable		 1jnoA-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.86A 1jnoB-2jgpA:
undetectable		 1jnoB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.91A 1jo4A-2jgpA:
undetectable		 1jo4A-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.91A 1jo4B-2jgpA:
undetectable		 1jo4B-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.79A 1magA-2jgpA:
undetectable		 1magA-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.78A 1magB-2jgpA:
undetectable		 1magB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.97A 1mt1A-2jgpA:
undetectable
1mt1F-2jgpA:
1.1		 1mt1A-2jgpA:
8.52
1mt1F-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.96A 1mt1B-2jgpA:
1.1
1mt1C-2jgpA:
undetectable		 1mt1B-2jgpA:
11.37
1mt1C-2jgpA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.89A 1mt1G-2jgpA:
undetectable
1mt1J-2jgpA:
1.1		 1mt1G-2jgpA:
8.52
1mt1J-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.91A 1mt1H-2jgpA:
1.1
1mt1K-2jgpA:
undetectable		 1mt1H-2jgpA:
11.37
1mt1K-2jgpA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 5 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.90A 1n13B-2jgpA:
1.1
1n13C-2jgpA:
undetectable		 1n13B-2jgpA:
11.37
1n13C-2jgpA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 8 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.91A 1n13A-2jgpA:
undetectable
1n13F-2jgpA:
1.1		 1n13A-2jgpA:
8.52
1n13F-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.92A 1n13H-2jgpA:
1.1
1n13K-2jgpA:
undetectable		 1n13H-2jgpA:
11.37
1n13K-2jgpA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.90A 1n13G-2jgpA:
undetectable
1n13J-2jgpA:
1.1		 1n13G-2jgpA:
8.52
1n13J-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.92A 1n13I-2jgpA:
undetectable
1n13L-2jgpA:
undetectable		 1n13I-2jgpA:
8.52
1n13L-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.87A 1ng8A-2jgpA:
undetectable		 1ng8A-2jgpA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.87A 1ng8B-2jgpA:
undetectable		 1ng8B-2jgpA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.94A 1nrmA-2jgpA:
undetectable		 1nrmA-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.94A 1nrmB-2jgpA:
undetectable		 1nrmB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.87A 1nruA-2jgpA:
undetectable		 1nruA-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 ALA A  32
VAL A  30
TRP A  21
 None
 0.87A 1nruB-2jgpA:
undetectable		 1nruB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 ALA A  15
LEU A  17
ILE A  72
SER A  11
 None
 1.07A 1sbrA-2jgpA:
undetectable
1sbrB-2jgpA:
1.5		 1sbrA-2jgpA:
18.64
1sbrB-2jgpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 LEU A  75
PHE A  78
ALA A  77
LEU A  17
 None
 0.97A 1ukbA-2jgpA:
undetectable		 1ukbA-2jgpA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 7 ALA A 421
ILE A 286
ILE A 353
ASP A 431
PHE A 430
 None
 1.01A 1upfB-2jgpA:
undetectable		 1upfB-2jgpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 12 ILE A 310
LEU A 342
TYR A 346
VAL A 482
GLU A 495
 None
 1.23A 2bxfA-2jgpA:
undetectable		 2bxfA-2jgpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.97A 2qqcB-2jgpA:
1.1
2qqcC-2jgpA:
undetectable		 2qqcB-2jgpA:
11.58
2qqcC-2jgpA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.94A 2qqcA-2jgpA:
undetectable
2qqcF-2jgpA:
1.1		 2qqcA-2jgpA:
8.53
2qqcF-2jgpA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.97A 2qqcG-2jgpA:
undetectable
2qqcJ-2jgpA:
1.1		 2qqcG-2jgpA:
8.53
2qqcJ-2jgpA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.96A 2qqcI-2jgpA:
undetectable
2qqcL-2jgpA:
1.1		 2qqcI-2jgpA:
8.53
2qqcL-2jgpA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.88A 2qqdA-2jgpA:
undetectable
2qqdE-2jgpA:
1.1		 2qqdA-2jgpA:
8.75
2qqdE-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 11 PHE A 501
PHE A 392
GLN A 394
ILE A 508
PRO A 512
 None
 1.33A 2vcdA-2jgpA:
undetectable		 2vcdA-2jgpA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 PHE A 389
LEU A 335
ALA A 338
PHE A 501
 None
 0.98A 2vcvA-2jgpA:
undetectable		 2vcvA-2jgpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 9 PHE A 430
LEU A 418
LEU A 414
ALA A 378
PHE A 282
 None
 1.21A 2vcvE-2jgpA:
undetectable		 2vcvE-2jgpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 PHE A 389
LEU A 335
ALA A 338
PHE A 501
 None
 0.96A 2vcvL-2jgpA:
undetectable		 2vcvL-2jgpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 LEU A 242
SER A 231
ASP A 228
GLU A 238
 None
None
SO4  A1523 (-4.9A)
None
 1.28A 2vn1B-2jgpA:
undetectable		 2vn1B-2jgpA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 12 PHE A 392
VAL A 396
PHE A 497
LEU A 291
ALA A 344
 None
 1.25A 3apxA-2jgpA:
undetectable		 3apxA-2jgpA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 TRP A 261
ALA A  83
VAL A  87
 None
 0.97A 3l8lA-2jgpA:
undetectable
3l8lB-2jgpA:
undetectable		 3l8lA-2jgpA:
5.16
3l8lB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 SER A 151
LEU A 242
ARG A 153
ILE A 204
 None
 1.06A 3ln1C-2jgpA:
undetectable		 3ln1C-2jgpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 9 PHE A 469
LEU A 502
ILE A 480
ALA A 471
ALA A 505
 None
 1.07A 3mdvA-2jgpA:
undetectable		 3mdvA-2jgpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 12 PHE A 392
LEU A 336
TYR A 339
VAL A 354
ALA A 344
 None
 1.43A 4a84A-2jgpA:
2.5		 4a84A-2jgpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 12 PHE A 389
PHE A 469
LEU A 502
ILE A 480
ALA A 505
 None
 0.91A 4enhA-2jgpA:
undetectable		 4enhA-2jgpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 8 LYS A   3
ILE A  72
PHE A  36
GLY A  40
 None
 0.91A 4hdlA-2jgpA:
undetectable		 4hdlA-2jgpA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 SER A 102
TYR A 255
PRO A 410
 None
 0.96A 4kahA-2jgpA:
undetectable		 4kahA-2jgpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 SER A 102
TYR A 255
PRO A 410
 None
 0.96A 4kahB-2jgpA:
undetectable		 4kahB-2jgpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 SER A 102
TYR A 255
PRO A 410
 None
 0.94A 4kbeB-2jgpA:
undetectable		 4kbeB-2jgpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 GLU A 238
ARG A 148
HIS A 149
 None
 0.79A 4kf9A-2jgpA:
undetectable		 4kf9A-2jgpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 7 PHE A 373
ASP A 228
SER A 231
SER A 151
 None
SO4  A1523 (-4.9A)
None
None
 1.27A 4lv9A-2jgpA:
undetectable
4lv9B-2jgpA:
undetectable		 4lv9A-2jgpA:
23.56
4lv9B-2jgpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 VAL A 334
ALA A 505
PHE A 389
 None
 0.92A 4olbA-2jgpA:
undetectable		 4olbA-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 12 GLY A 481
LEU A 335
TYR A 339
LEU A 342
ILE A 508
 None
 1.05A 4pd4C-2jgpA:
undetectable		 4pd4C-2jgpA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 10 THR A 220
ILE A 226
LEU A 236
VAL A 230
MET A 123
 DIO  A1525 ( 3.8A)
None
DIO  A1525 ( 3.8A)
None
None
 1.17A 4r3aB-2jgpA:
undetectable		 4r3aB-2jgpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 VAL A 334
ALA A 505
PHE A 389
 None
 0.89A 4w5nA-2jgpA:
undetectable		 4w5nA-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 8 ILE A 514
LEU A 316
LEU A 502
ILE A 504
 None
 0.99A 4xtaB-2jgpA:
undetectable		 4xtaB-2jgpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		5 / 12 LEU A  75
LEU A  17
ILE A  79
VAL A  49
LEU A  66
 None
 0.97A 4y0sA-2jgpA:
undetectable		 4y0sA-2jgpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		3 / 3 VAL A 334
ALA A 505
PHE A 389
 None
 0.90A 5js1A-2jgpA:
undetectable		 5js1A-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 5 LEU A 279
TYR A 277
LEU A 414
TYR A 409
 None
 1.38A 5ki6A-2jgpA:
undetectable		 5ki6A-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2jgp TYROCIDINE
SYNTHETASE 3
(Brevibacillus
brevis) 		4 / 6 LEU A  66
PHE A  36
ASP A  35
HIS A  42
 None
None
None
SO4  A1524 (-3.6A)
 0.90A 5om3A-2jgpA:
undetectable
5om3B-2jgpA:
undetectable		 5om3A-2jgpA:
9.78
5om3B-2jgpA:
5.72