SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.17A 1gtfJ-2jgrA:
undetectable
1gtfK-2jgrA:
undetectable		 1gtfJ-2jgrA:
14.23
1gtfK-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2jgr YEGS
(Escherichia
coli) 		5 / 11 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.14A 1gtfQ-2jgrA:
undetectable
1gtfR-2jgrA:
undetectable		 1gtfQ-2jgrA:
14.23
1gtfR-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2jgr YEGS
(Escherichia
coli) 		5 / 9 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.12A 1gtfR-2jgrA:
undetectable
1gtfS-2jgrA:
undetectable		 1gtfR-2jgrA:
14.23
1gtfS-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2jgr YEGS
(Escherichia
coli) 		4 / 7 ALA A  96
ILE A  70
ASP A 269
PHE A  99
 None
 0.94A 1upfB-2jgrA:
undetectable		 1upfB-2jgrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 11 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.14A 1utdS-2jgrA:
undetectable
1utdT-2jgrA:
undetectable		 1utdS-2jgrA:
14.23
1utdT-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.13A 1utdU-2jgrA:
undetectable
1utdV-2jgrA:
undetectable		 1utdU-2jgrA:
14.23
1utdV-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2jgr YEGS
(Escherichia
coli) 		5 / 12 GLY A 205
GLY A 206
GLY A 207
LEU A 210
ASN A 137
 None
 1.16A 1xdsB-2jgrA:
undetectable		 1xdsB-2jgrA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2jgr YEGS
(Escherichia
coli) 		5 / 12 ILE A  90
GLY A  89
LEU A   9
GLY A  64
ALA A 116
 None
 0.76A 2fk8A-2jgrA:
undetectable		 2fk8A-2jgrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2jgr YEGS
(Escherichia
coli) 		4 / 6 LEU A 223
ASN A 137
ILE A 280
PHE A 256
 None
 1.20A 2jn3A-2jgrA:
undetectable		 2jn3A-2jgrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2jgr YEGS
(Escherichia
coli) 		4 / 7 ILE A 136
THR A 140
ILE A  90
GLY A 207
 None
 0.80A 2v0mB-2jgrA:
undetectable		 2v0mB-2jgrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2jgr YEGS
(Escherichia
coli) 		4 / 9 ILE A 216
ALA A 100
VAL A 103
CYH A 295
 None
 0.78A 2vufB-2jgrA:
undetectable		 2vufB-2jgrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2jgr YEGS
(Escherichia
coli) 		4 / 8 GLY A  66
GLU A  72
ILE A  90
ALA A 100
 POP  A1300 (-3.5A)
None
None
None
 0.95A 3aodA-2jgrA:
undetectable		 3aodA-2jgrA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2jgr YEGS
(Escherichia
coli) 		5 / 12 ASN A 137
ASP A  98
GLY A 270
ASN A 267
PHE A 266
 None
 1.21A 3k13C-2jgrA:
undetectable		 3k13C-2jgrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2jgr YEGS
(Escherichia
coli) 		3 / 3 ASP A 218
ARG A 299
ARG A 224
 None
 0.94A 3k37A-2jgrA:
undetectable		 3k37A-2jgrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jgr YEGS
(Escherichia
coli) 		5 / 9 LEU A  77
LEU A   8
ILE A  10
ALA A  46
ALA A  53
 None
 1.10A 3mdvA-2jgrA:
undetectable		 3mdvA-2jgrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2jgr YEGS
(Escherichia
coli) 		5 / 9 ASP A 218
GLY A 219
ILE A 124
GLY A 199
LEU A 215
 None
 1.01A 3ogpB-2jgrA:
undetectable		 3ogpB-2jgrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2jgr YEGS
(Escherichia
coli) 		4 / 6 ALA A  63
ILE A  70
LEU A  88
ALA A 116
 None
 0.90A 3r9sC-2jgrA:
undetectable		 3r9sC-2jgrA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2jgr YEGS
(Escherichia
coli) 		4 / 5 LEU A 223
GLY A 251
PHE A 226
ASN A 213
 None
 1.02A 3uq6B-2jgrA:
undetectable		 3uq6B-2jgrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2jgr YEGS
(Escherichia
coli) 		5 / 12 LEU A  91
LEU A  93
SER A  15
THR A  16
VAL A  73
 None
 1.24A 4f4dB-2jgrA:
5.9		 4f4dB-2jgrA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2jgr YEGS
(Escherichia
coli) 		4 / 8 GLY A 219
ILE A 124
LEU A 298
LEU A 297
 None
 0.73A 4mwzB-2jgrA:
undetectable		 4mwzB-2jgrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2jgr YEGS
(Escherichia
coli) 		4 / 7 ASP A 178
ARG A 179
PHE A 143
HIS A 262
 None
 1.50A 4o4dA-2jgrA:
undetectable		 4o4dA-2jgrA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2jgr YEGS
(Escherichia
coli) 		5 / 12 ALA A 100
ILE A 105
ILE A 216
ASN A 217
LEU A 298
 None
 1.20A 4r3aA-2jgrA:
undetectable		 4r3aA-2jgrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2jgr YEGS
(Escherichia
coli) 		3 / 3 VAL A  73
LEU A  77
VAL A  50
 None
 0.49A 4wq4A-2jgrA:
1.9		 4wq4A-2jgrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.16A 5eevA-2jgrA:
3.0
5eevB-2jgrA:
undetectable		 5eevA-2jgrA:
14.23
5eevB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5eewA-2jgrA:
1.4
5eewB-2jgrA:
undetectable		 5eewA-2jgrA:
14.23
5eewB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.16A 5eexA-2jgrA:
1.4
5eexB-2jgrA:
undetectable		 5eexA-2jgrA:
14.23
5eexB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5eeyA-2jgrA:
3.0
5eeyB-2jgrA:
1.3		 5eeyA-2jgrA:
14.23
5eeyB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5eezA-2jgrA:
undetectable
5eezB-2jgrA:
undetectable		 5eezA-2jgrA:
14.23
5eezB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef0A-2jgrA:
undetectable
5ef0B-2jgrA:
1.2		 5ef0A-2jgrA:
14.23
5ef0B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef1A-2jgrA:
1.4
5ef1B-2jgrA:
undetectable		 5ef1A-2jgrA:
14.23
5ef1B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef2A-2jgrA:
3.0
5ef2B-2jgrA:
undetectable		 5ef2A-2jgrA:
14.23
5ef2B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef3A-2jgrA:
undetectable
5ef3B-2jgrA:
undetectable		 5ef3A-2jgrA:
14.23
5ef3B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2jgr YEGS
(Escherichia
coli) 		3 / 3 CYH A 211
MET A 138
ASN A 200
 None
 1.10A 5qh8A-2jgrA:
undetectable		 5qh8A-2jgrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 ALA A  53
VAL A  58
ILE A 117
ALA A 116
ALA A  63
 None
 1.06A 6h1lA-2jgrA:
undetectable		 6h1lA-2jgrA:
22.10