SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		6 / 7 ASN A 104
LEU A 106
SER A 108
TYR A 125
THR A 127
VAL A 129
 BTN  A1001 ( 4.4A)
None
BTN  A1001 (-2.6A)
BTN  A1001 (-4.5A)
BTN  A1001 (-3.7A)
None
 0.37A 2uz2A-2jgsA:
undetectable		 2uz2A-2jgsA:
35.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		4 / 8 SER A  59
LYS A   4
SER A  33
THR A  35
 None
None
BTN  A1001 (-2.5A)
BTN  A1001 (-3.5A)
 0.95A 4ikjA-2jgsA:
undetectable
4ikjB-2jgsA:
undetectable		 4ikjA-2jgsA:
21.74
4ikjB-2jgsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		4 / 8 LEU A   7
LEU A  98
ILE A  75
THR A  53
 None
 1.05A 5ljbA-2jgsA:
3.0		 5ljbA-2jgsA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		6 / 10 TYR A 125
TRP A  28
PHE A  30
THR A  35
PHE A  37
TRP A  55
 BTN  A1001 (-4.5A)
BTN  A1001 (-3.6A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-3.5A)
None
BTN  A1001 (-3.3A)
 0.20A 5lurA-2jgsA:
8.7		 5lurA-2jgsA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		6 / 11 TYR A 125
TRP A  28
PHE A  30
THR A  35
PHE A  37
TRP A  55
 BTN  A1001 (-4.5A)
BTN  A1001 (-3.6A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-3.5A)
None
BTN  A1001 (-3.3A)
 0.22A 5lurB-2jgsA:
7.7		 5lurB-2jgsA:
50.91