SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		5 / 12 ILE B 254
ALA A  48
LEU A  37
ILE A  35
HIS A  71
 None
 1.15A 1bsxA-2jgzB:
2.7		 1bsxA-2jgzB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		5 / 12 ILE B 254
ALA A  48
LEU A  37
ILE A  35
HIS A  71
 None
 1.15A 1bsxB-2jgzB:
2.8		 1bsxB-2jgzB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 ASP A 127
ASP A 145
ARG A  50
THR A  14
 None
None
TPO  A 160 ( 2.8A)
None
 1.35A 1ceaA-2jgzA:
undetectable
1ceaB-2jgzA:
undetectable		 1ceaA-2jgzA:
13.03
1ceaB-2jgzA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 4 ILE B 289
LEU A  76
VAL A  44
ILE A  49
 None
 0.92A 1fm6D-2jgzB:
3.4		 1fm6D-2jgzB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 134
ALA A 144
 None
 0.64A 1opjA-2jgzA:
16.3		 1opjA-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
ALA A 144
 None
 0.66A 1opjB-2jgzA:
16.3		 1opjB-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 7 LEU B 244
VAL B 247
GLY B 248
ASP B 231
 None
 0.95A 1t88A-2jgzB:
undetectable		 1t88A-2jgzB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		3 / 3 TRP B 208
THR B 276
TYR B 277
 None
 0.79A 2a3aA-2jgzB:
undetectable		 2a3aA-2jgzB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		3 / 3 TRP B 208
THR B 276
TYR B 277
 None
 0.75A 2a3aB-2jgzB:
undetectable		 2a3aB-2jgzB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		3 / 3 TRP B 208
THR B 276
TYR B 277
 None
 0.80A 2a3bA-2jgzB:
undetectable		 2a3bA-2jgzB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 LEU A  87
ILE A 135
LEU A 103
ILE A 104
 None
 0.92A 2azxA-2jgzA:
undetectable		 2azxA-2jgzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 LEU A 189
ILE A 141
GLY A 114
CYH A 118
HIS A 119
 None
 1.38A 2b17A-2jgzA:
undetectable		 2b17A-2jgzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 LEU A 189
ILE A 141
GLY A 114
CYH A 118
PHE A 146
 None
 1.13A 2b17A-2jgzA:
undetectable		 2b17A-2jgzA:
16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ILE A  10
VAL A  18
VAL A  64
PHE A  80
ASN A 132
LEU A 134
ALA A 144
ASP A 145
 None
 0.84A 2eufB-2jgzA:
36.0		 2eufB-2jgzA:
49.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A  18
VAL A  64
PHE A  80
ASP A  86
ASN A 132
LEU A 134
ALA A 144
ASP A 145
 None
 0.66A 2eufB-2jgzA:
36.0		 2eufB-2jgzA:
49.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.77A 2hyyA-2jgzA:
16.4		 2hyyA-2jgzA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.75A 2hyyB-2jgzA:
23.2		 2hyyB-2jgzA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 134
ALA A 144
 None
 0.65A 2hyyC-2jgzA:
23.4		 2hyyC-2jgzA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.73A 2hyyD-2jgzA:
16.5		 2hyyD-2jgzA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 8 ILE A  49
ILE A  52
ILE B 254
VAL A  69
 None
 0.68A 2nniA-2jgzA:
undetectable		 2nniA-2jgzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 5 HIS B 304
PRO B 300
TYR B 175
TYR B 177
 None
 1.48A 2ombA-2jgzB:
undetectable
2ombB-2jgzB:
undetectable		 2ombA-2jgzB:
22.18
2ombB-2jgzB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 7 TYR B 191
TYR B 334
ARG B 195
ARG B 188
 None
 1.35A 2qmqA-2jgzB:
0.0		 2qmqA-2jgzB:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		5 / 12 SER B 413
VAL B 387
GLN B 417
LEU B 422
ILE B 355
 None
 1.24A 2xrlA-2jgzB:
1.6		 2xrlA-2jgzB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		5 / 12 LEU B 383
LEU B 329
MET B 389
VAL B 388
PHE B 339
 None
 1.41A 2yloA-2jgzB:
undetectable		 2yloA-2jgzB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 115
SER A 106
ILE A 192
ASN A  62
LEU A 143
 None
 1.16A 3cjtG-2jgzA:
undetectable		 3cjtG-2jgzA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 115
SER A 106
ILE A 192
ASN A  62
LEU A 143
 None
 1.12A 3cjtK-2jgzA:
undetectable		 3cjtK-2jgzA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 275
ALA A 183
LEU A 115
ALA A 116
LEU A 108
 None
 1.11A 3dauA-2jgzA:
undetectable		 3dauA-2jgzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
LEU A 134
ALA A 144
 None
 0.69A 3gvuA-2jgzA:
16.8		 3gvuA-2jgzA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
GLU A  51
VAL A  64
LEU A 134
ALA A 144
 None
 0.59A 3ik3A-2jgzA:
23.2		 3ik3A-2jgzA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
VAL A  64
HIS A 125
LEU A 134
ALA A 144
 None
 0.38A 3ik3A-2jgzA:
23.2		 3ik3A-2jgzA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
GLU A  51
VAL A  64
LEU A 134
ALA A 144
 None
 0.55A 3ik3B-2jgzA:
23.0		 3ik3B-2jgzA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
VAL A  64
HIS A 125
LEU A 134
ALA A 144
 None
 0.39A 3ik3B-2jgzA:
23.0		 3ik3B-2jgzA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.68A 3k5vA-2jgzA:
16.3		 3k5vA-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.67A 3k5vB-2jgzA:
16.2		 3k5vB-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 11 ILE A  10
ALA A  31
LYS A  33
VAL A  64
PHE A  80
PHE A  82
LEU A 134
 None
 0.78A 3miyA-2jgzA:
19.6		 3miyA-2jgzA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 ILE A  10
ALA A  31
LYS A  33
PHE A  80
PHE A  82
LEU A 134
 None
 0.78A 3miyB-2jgzA:
24.0		 3miyB-2jgzA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.71A 3ms9A-2jgzA:
22.8		 3ms9A-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.74A 3mssA-2jgzA:
16.5		 3mssA-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.76A 3mssC-2jgzA:
16.5		 3mssC-2jgzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  10
VAL A  18
ALA A  31
LYS A  33
LEU A  55
PHE A 146
 None
 1.18A 3og7A-2jgzA:
9.7		 3og7A-2jgzA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 134
ALA A 144
 None
 0.76A 3pyyA-2jgzA:
16.6		 3pyyA-2jgzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
LEU A 134
ALA A 144
 None
 0.67A 3pyyB-2jgzA:
16.5		 3pyyB-2jgzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE A  35
LEU A  76
LEU B 290
SER B 256
 None
 0.79A 3r9vA-2jgzA:
1.6
3r9vB-2jgzA:
undetectable		 3r9vA-2jgzA:
21.45
3r9vB-2jgzA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  51
LEU A  55
PHE A  80
HIS A 125
ALA A 144
 None
 0.65A 3rgfA-2jgzA:
12.0		 3rgfA-2jgzA:
33.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 5 TYR B 371
ILE B 355
LEU B 356
LYS B 354
 None
 1.33A 3sueC-2jgzB:
undetectable		 3sueC-2jgzB:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 ALA A  31
VAL A  64
PHE A  80
PHE A  82
ASP A  86
LEU A 134
 None
 0.69A 3ti1A-2jgzA:
33.9		 3ti1A-2jgzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 ALA A  31
VAL A  64
PHE A  82
ASP A  86
LYS A  88
LEU A 134
 None
 1.12A 3ti1A-2jgzA:
33.9		 3ti1A-2jgzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 ILE A  10
ALA A  31
VAL A  64
PHE A  80
PHE A  82
LEU A 134
 None
 0.75A 3ti1A-2jgzA:
33.9		 3ti1A-2jgzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 ILE A  10
VAL A  64
PHE A  80
PHE A  82
LEU A 134
ASP A 145
 None
 1.09A 3ti1A-2jgzA:
33.9		 3ti1A-2jgzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 VAL A  64
PHE A  80
PHE A  82
ASP A  86
LEU A 134
ASP A 145
 None
 0.89A 3ti1A-2jgzA:
33.9		 3ti1A-2jgzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		5 / 12 ILE B 254
ALA A  48
LEU A  37
ILE A  35
HIS A  71
 None
 1.10A 3uvvA-2jgzB:
undetectable		 3uvvA-2jgzB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A  31
GLU A  51
LEU A  55
ILE A  63
HIS A 125
LEU A 134
ALA A 144
 None
 0.77A 4c8bB-2jgzA:
15.8		 4c8bB-2jgzA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR B 177
HIS A 121
ARG A 122
 None
 1.13A 4e7bC-2jgzB:
undetectable		 4e7bC-2jgzB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		3 / 3 ARG B 308
TYR A 179
ASN A 272
 None
 0.91A 4ffwB-2jgzB:
undetectable		 4ffwB-2jgzB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
ASP A  86
ASP A 127
LYS A 129
ASN A 132
LEU A 134
ASP A 145
 None
 0.67A 4i41A-2jgzA:
19.5		 4i41A-2jgzA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 ILE A  35
ILE A  52
VAL A  44
PRO A  45
 None
 0.63A 4jltA-2jgzA:
undetectable		 4jltA-2jgzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 LYS A 237
PRO A 238
SER A 239
 None
 0.29A 4k50I-2jgzA:
undetectable		 4k50I-2jgzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 5 LEU A  87
PRO A 130
LEU A 133
ILE A 141
 None
 0.97A 4klrA-2jgzA:
undetectable		 4klrA-2jgzA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ILE A  10
ALA A  31
VAL A  64
PHE A  82
LEU A  83
ASP A 145
 None
 0.75A 4ks8A-2jgzA:
28.2		 4ks8A-2jgzA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ILE A  10
ALA A  31
VAL A  64
PHE A  82
LEU A  83
LEU A 134
 None
 0.62A 4ks8A-2jgzA:
28.2		 4ks8A-2jgzA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 VAL A  18
ALA A  31
ASP A  86
LEU A 134
 None
 0.82A 4l9iA-2jgzA:
10.1		 4l9iA-2jgzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  13
VAL A  18
ALA A  31
LYS A  33
ASP A  86
LEU A 134
ASP A 145
 None
 0.97A 4mkcA-2jgzA:
24.3		 4mkcA-2jgzA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 8 GLY A  13
ALA A  31
ASP A  86
ASN A 132
LEU A 134
ASP A 145
 None
 0.68A 4ogrA-2jgzA:
36.9		 4ogrA-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 8 ILE A  10
GLY A  13
VAL A  18
ALA A  31
ASN A 132
LEU A 134
ASP A 145
 None
 0.65A 4ogrA-2jgzA:
36.9		 4ogrA-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 7 ALA A  31
ASP A  86
ASN A 132
LEU A 134
ASP A 145
 None
 0.49A 4ogrE-2jgzA:
36.0		 4ogrE-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 9 GLY A  13
VAL A  18
ALA A  31
ASP A  86
ASN A 132
LEU A 134
ASP A 145
 None
 0.84A 4ogrI-2jgzA:
36.4		 4ogrI-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 9 ILE A  10
GLY A  13
VAL A  18
ALA A  31
ASN A 132
LEU A 134
ASP A 145
 None
 0.76A 4ogrI-2jgzA:
36.4		 4ogrI-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  10
ALA A  31
GLU A  51
LEU A 134
ALA A 144
ASP A 145
 None
 0.77A 4qmnA-2jgzA:
28.6		 4qmnA-2jgzA:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  10
GLY A  11
VAL A  18
ALA A  31
LEU A  83
LEU A 134
 None
 0.64A 4qmzA-2jgzA:
29.1		 4qmzA-2jgzA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 7 GLY B 296
GLN B 185
ARG B 232
ILE B 229
 None
 0.92A 4txnB-2jgzB:
undetectable		 4txnB-2jgzB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 7 GLY B 296
GLN B 185
ARG B 232
ILE B 229
 None
 0.95A 4txnD-2jgzB:
undetectable		 4txnD-2jgzB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
GLU A  51
HIS A 125
LEU A 134
ALA A 144
 None
 0.63A 4tyjA-2jgzA:
23.0		 4tyjA-2jgzA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
CYH A 118
HIS A 125
ALA A 144
 None
 1.11A 4v04A-2jgzA:
22.6		 4v04A-2jgzA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 VAL A 252
LEU A 255
VAL A 197
 None
 0.57A 4wq4A-2jgzA:
undetectable		 4wq4A-2jgzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 263
ASP A 256
ILE A 192
 None
 0.71A 4xi3D-2jgzA:
undetectable		 4xi3D-2jgzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
LYS A  33
LEU A  55
ASP A 145
PHE A 146
 None
 0.97A 4xv2B-2jgzA:
24.2		 4xv2B-2jgzA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 ALA A  31
PHE A  82
LEU A 134
ALA A 144
ASP A 145
 None
 0.64A 5ajqB-2jgzA:
24.4		 5ajqB-2jgzA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 6 HIS B 320
ILE B 412
TYR B 404
TYR B 224
 None
 1.23A 5ih0A-2jgzB:
undetectable		 5ih0A-2jgzB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		5 / 11 ARG B 202
ILE B 230
ILE B 289
VAL B 187
VAL B 337
 None
 1.41A 5jkwA-2jgzB:
undetectable		 5jkwA-2jgzB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		3 / 3 TYR B 404
TYR B 224
GLN B 220
 None
 1.04A 5jsdA-2jgzB:
undetectable
5jsdB-2jgzB:
undetectable		 5jsdA-2jgzB:
15.63
5jsdB-2jgzB:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		3 / 3 TYR B 404
TYR B 224
GLN B 220
 None
 1.04A 5jsdB-2jgzB:
undetectable
5jsdC-2jgzB:
undetectable		 5jsdB-2jgzB:
15.63
5jsdC-2jgzB:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
ASP A 145
 None
 0.69A 5l2iA-2jgzA:
18.9		 5l2iA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
 None
 0.66A 5l2iA-2jgzA:
18.9		 5l2iA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 GLY A  11
VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
 None
 0.80A 5l2tA-2jgzA:
19.3		 5l2tA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  11
VAL A  64
PHE A  80
ASP A  86
LEU A 134
ALA A 144
ASP A 145
 None
 0.93A 5l2tA-2jgzA:
19.3		 5l2tA-2jgzA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  10
GLY A  11
VAL A  18
ALA A  31
PHE A  80
ASP A  86
LEU A 134
 None
 1.03A 5l2tA-2jgzA:
19.3		 5l2tA-2jgzA:
48.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  31
VAL A  64
HIS A 125
LEU A 134
ALA A 144
 None
 0.46A 5mo4A-2jgzA:
16.2		 5mo4A-2jgzA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 ALA A  31
GLU A  51
LEU A 134
ASP A 145
 None
 0.55A 5owrA-2jgzA:
22.9		 5owrA-2jgzA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 7 SER B 310
ALA B 323
ILE B 355
LEU B 356
 None
 1.05A 5te8A-2jgzB:
undetectable		 5te8A-2jgzB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens) 		4 / 7 LEU B 301
VAL A 123
TYR B 177
GLU A  57
 None
 1.24A 5umwA-2jgzB:
undetectable
5umwF-2jgzB:
undetectable		 5umwA-2jgzB:
16.22
5umwF-2jgzB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 GLY A  11
VAL A  18
ALA A  31
PHE A  80
ALA A 144
 None
 0.42A 5xv7A-2jgzA:
19.9		 5xv7A-2jgzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  78
LEU A 134
 None
 0.69A 5yu9B-2jgzA:
22.2		 5yu9B-2jgzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 134
ALA A 144
 None
 0.69A 6hd6A-2jgzA:
16.3		 6hd6A-2jgzA:
24.19