SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 2jh1 MICRONEMAL PROTEIN 1
(Toxoplasma
gondii) 		5 / 12 GLY A  92
GLN A 131
ASN A 135
ILE A  21
VAL A  88
 None
None
ACT  A1262 (-3.6A)
None
None
 0.98A 4azwA-2jh1A:
undetectable		 4azwA-2jh1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2jh1 MICRONEMAL PROTEIN 1
(Toxoplasma
gondii) 		4 / 6 TYR A 203
TYR A 137
GLY A 144
GLU A 165
 None
None
ACT  A1257 ( 3.9A)
None
 0.90A 5emlA-2jh1A:
undetectable		 5emlA-2jh1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2jh1 MICRONEMAL PROTEIN 1
(Toxoplasma
gondii) 		4 / 6 PHE A 142
PRO A 143
GLY A 144
THR A 145
 None
None
ACT  A1257 ( 3.9A)
None
 0.72A 5x24A-2jh1A:
undetectable		 5x24A-2jh1A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2jh1 MICRONEMAL PROTEIN 1
(Toxoplasma
gondii) 		4 / 5 GLY A 193
ASP A 199
ARG A 192
ARG A 191
 None
 1.37A 6dwdB-2jh1A:
undetectable
6dwdD-2jh1A:
undetectable		 6dwdB-2jh1A:
17.40
6dwdD-2jh1A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2jh1 MICRONEMAL PROTEIN 1
(Toxoplasma
gondii) 		4 / 5 ARG A 192
ARG A 191
GLY A 193
ASP A 199
 None
 1.39A 6dwjB-2jh1A:
undetectable
6dwjD-2jh1A:
undetectable		 6dwjB-2jh1A:
17.40
6dwjD-2jh1A:
17.40