SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
5 / 12 LEU A 138
ALA A 126
GLN A 127
LEU A  94
PHE A 132
None
1.40A 2oaxE-2jheA:
undetectable
2oaxE-2jheA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
5 / 10 ILE A  31
ILE A  33
GLY A  37
PHE A   6
LEU A  17
None
AE3  A1191 (-4.6A)
AE3  A1191 (-3.4A)
None
None
1.18A 3elzB-2jheA:
undetectable
3elzB-2jheA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
4 / 7 ASN A 106
ALA A 108
SER A 109
VAL A 174
None
1.06A 4ijiH-2jheA:
undetectable
4ijiH-2jheA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
5 / 10 VAL A   5
VAL A  64
ILE A  61
LEU A  28
LEU A  21
None
1.04A 4jtqA-2jheA:
undetectable
4jtqA-2jheA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
5 / 8 LEU A  28
LEU A  21
LEU A  54
ILE A  31
VAL A   5
None
1.41A 4klaA-2jheA:
undetectable
4klaA-2jheA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
4 / 7 VAL A  64
ILE A  61
LEU A  28
LEU A  21
None
0.96A 4l1wA-2jheA:
undetectable
4l1wA-2jheA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
5 / 11 LEU A  94
SER A 109
LEU A 117
ASP A 103
LEU A 120
None
1.46A 4or0A-2jheA:
undetectable
4or0A-2jheA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli)
4 / 7 LEU A  54
THR A  14
MET A  55
LEU A  46
None
AE3  A1191 (-4.3A)
None
None
1.08A 5jq7B-2jheA:
undetectable
5jq7B-2jheA:
18.23