SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jhn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A  41
VAL A  48
GLY A  62
GLU A  68
 None
 1.01A 1jlfA-2jhnA:
undetectable
1jlfB-2jhnA:
undetectable		 1jlfA-2jhnA:
21.00
1jlfB-2jhnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 136
LEU A 139
PHE A 161
GLN A 164
ILE A 167
 None
 1.24A 2jjpA-2jhnA:
undetectable		 2jjpA-2jhnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 200
LEU A 197
ALA A 230
ALA A 125
 None
 0.83A 2vcvF-2jhnA:
undetectable		 2vcvF-2jhnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		5 / 10 TYR A 251
TYR A 284
PHE A 270
VAL A 243
LEU A 281
 None
 1.23A 2w98A-2jhnA:
undetectable		 2w98A-2jhnA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 211
LEU A 227
VAL A 226
LEU A 231
 None
 0.82A 2w98B-2jhnA:
undetectable		 2w98B-2jhnA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 5 TYR A  51
ALA A  47
TYR A  79
MET A  16
 None
None
GOL  A1300 (-4.3A)
None
 1.09A 3d91A-2jhnA:
undetectable		 3d91A-2jhnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  56
GLU A  86
TYR A 106
 None
 0.83A 3k37B-2jhnA:
undetectable		 3k37B-2jhnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 7 VAL A 243
VAL A 247
LEU A 250
ASN A 234
 None
None
None
GOL  A1302 (-4.3A)
 0.80A 4e1gB-2jhnA:
undetectable		 4e1gB-2jhnA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  73
TRP A  69
ILE A   4
 None
 1.04A 4mwxA-2jhnA:
undetectable		 4mwxA-2jhnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 7 VAL A  20
LEU A 231
PHE A 282
LEU A 225
 None
 1.22A 6aycA-2jhnA:
undetectable		 6aycA-2jhnA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 131
SER A 132
ALA A 140
LEU A 180
 None
 1.06A 6dwnA-2jhnA:
undetectable		 6dwnA-2jhnA:
12.97