SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 7 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
 None
 1.01A 11gsA-2jhqA:
undetectable		 11gsA-2jhqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 10 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
 None
 1.06A 13gsA-2jhqA:
undetectable		 13gsA-2jhqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 8 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
 None
 1.03A 2gssA-2jhqA:
undetectable		 2gssA-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 8 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
 None
 1.04A 2gssB-2jhqA:
undetectable		 2gssB-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 11 ILE A  11
GLU A  52
PHE A  48
VAL A 148
THR A   6
 None
 1.20A 2w3aA-2jhqA:
undetectable		 2w3aA-2jhqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 12 ILE A  11
GLU A  52
PHE A  48
LEU A 126
THR A   6
 None
 1.32A 2w3mB-2jhqA:
undetectable		 2w3mB-2jhqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 9 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
 None
 1.11A 3csjB-2jhqA:
undetectable		 3csjB-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 7 TYR A  66
VAL A  79
ILE A  92
GLY A 109
 None
 0.93A 3gssA-2jhqA:
undetectable		 3gssA-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 7 TYR A  66
VAL A  79
ILE A  92
GLY A 109
 None
 0.93A 3gssB-2jhqA:
undetectable		 3gssB-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		3 / 3 ILE A  60
PHE A 203
HIS A 187
 None
 0.70A 3h0aA-2jhqA:
undetectable		 3h0aA-2jhqA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 8 TYR A  66
VAL A  79
ILE A  92
GLY A 109
 None
 0.96A 3hjoA-2jhqA:
undetectable		 3hjoA-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		3 / 3 GLU A 142
HIS A 167
THR A 124
 None
 0.89A 3hkuA-2jhqA:
undetectable		 3hkuA-2jhqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		6 / 11 ILE A  11
GLU A  52
PHE A  48
LEU A 126
VAL A 148
THR A   6
 None
 1.29A 3n0hA-2jhqA:
undetectable		 3n0hA-2jhqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 8 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
 None
 1.09A 3n9jA-2jhqA:
undetectable		 3n9jA-2jhqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		6 / 12 ILE A  11
GLU A  52
PHE A  48
LEU A 126
VAL A 148
THR A   6
 None
 1.29A 3s3vA-2jhqA:
undetectable		 3s3vA-2jhqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 9 PHE A  48
PHE A 144
ILE A  11
GLY A  12
PHE A  45
 None
 1.24A 3t3rB-2jhqA:
undetectable		 3t3rB-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 9 PHE A  48
PHE A 144
ILE A  11
GLY A  12
PHE A  45
 None
 1.23A 3t3rC-2jhqA:
undetectable		 3t3rC-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 10 PHE A  48
PHE A 144
ILE A  11
GLY A  12
PHE A  45
 None
 1.23A 3t3rD-2jhqA:
undetectable		 3t3rD-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 6 GLU A  14
TYR A  19
VAL A  27
PHE A  20
 None
 1.16A 4a97E-2jhqA:
undetectable		 4a97E-2jhqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 11 ILE A 215
VAL A  58
GLN A 117
SER A 113
GLY A 118
 None
 0.98A 4ac9B-2jhqA:
undetectable
4ac9C-2jhqA:
undetectable		 4ac9B-2jhqA:
17.77
4ac9C-2jhqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 12 ILE A  11
GLU A  52
PHE A  48
LEU A 126
THR A   6
 None
 1.23A 4cd2A-2jhqA:
undetectable		 4cd2A-2jhqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 5 PHE A  48
PHE A 144
ILE A  11
GLY A  12
 None
 0.97A 4ejjC-2jhqA:
undetectable		 4ejjC-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 8 ASP A   9
VAL A  10
GLY A  54
VAL A 148
ILE A  11
 None
 1.31A 4ll3A-2jhqA:
undetectable		 4ll3A-2jhqA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		7 / 8 GLY A  62
GLN A  63
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 None
None
None
None
CL  A1227 (-3.0A)
None
None
 0.83A 4wryA-2jhqA:
31.0		 4wryA-2jhqA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		6 / 8 GLY A  62
GLN A  63
TYR A  66
PHE A  77
ASN A 123
HIS A 187
 None
 0.91A 4wrzA-2jhqA:
30.6		 4wrzA-2jhqA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 None
None
None
CL  A1227 (-3.0A)
None
None
 0.68A 4wrzA-2jhqA:
30.6		 4wrzA-2jhqA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 7 GLY A  62
GLN A  63
TYR A  66
ASN A 123
 None
 0.75A 4ws0A-2jhqA:
30.5		 4ws0A-2jhqA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		5 / 7 GLY A  62
TYR A  66
PHE A  77
ASN A 123
HIS A 187
 None
 0.72A 4ws0A-2jhqA:
30.5		 4ws0A-2jhqA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 8 GLY A  62
GLN A  63
TYR A  66
ASN A 123
 None
 0.75A 4ws1A-2jhqA:
30.6		 4ws1A-2jhqA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 None
None
None
CL  A1227 (-3.0A)
None
None
 0.67A 4ws1A-2jhqA:
30.6		 4ws1A-2jhqA:
38.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 6 VAL A  59
ARG A 156
VAL A 148
PHE A  53
 None
 1.38A 5addA-2jhqA:
undetectable
5addB-2jhqA:
undetectable		 5addA-2jhqA:
19.23
5addB-2jhqA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 6 ARG A 156
VAL A 148
TRP A   7
PHE A  53
 None
 1.23A 5unvA-2jhqA:
undetectable
5unvB-2jhqA:
undetectable		 5unvA-2jhqA:
19.37
5unvB-2jhqA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		4 / 7 ARG A 156
VAL A 148
TRP A   7
PHE A  53
 None
 1.28A 5vujA-2jhqA:
undetectable
5vujB-2jhqA:
undetectable		 5vujA-2jhqA:
19.37
5vujB-2jhqA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jhq URACIL
DNA-GLYCOSYLASE
(Vibrio
cholerae) 		3 / 3 ASN A 123
VAL A  27
HIS A 136
 None
 0.86A 6a5yD-2jhqA:
undetectable		 6a5yD-2jhqA:
14.49