SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ji4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 173
ARG A 202
ALA A 165
LEU A 169
ILE A 341
 None
None
CL  A1369 (-4.0A)
None
None
 1.01A 1bsxA-2ji4A:
undetectable		 1bsxA-2ji4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 173
ARG A 202
ALA A 165
LEU A 169
ILE A 341
 None
None
CL  A1369 (-4.0A)
None
None
 1.01A 1bsxB-2ji4A:
undetectable		 1bsxB-2ji4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 4 ILE A  86
LEU A  89
VAL A  93
ALA A 101
 None
 0.65A 1mz9A-2ji4A:
undetectable		 1mz9A-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 5 ILE A  86
LEU A  89
VAL A  93
ALA A 101
 None
 0.58A 1mz9C-2ji4A:
undetectable		 1mz9C-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A  89
VAL A  93
CYH A  96
ALA A 101
 None
 1.14A 1mz9D-2ji4A:
undetectable		 1mz9D-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 4 LEU A  89
VAL A  93
CYH A  96
ALA A 101
 None
 0.94A 1mz9E-2ji4A:
undetectable		 1mz9E-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		3 / 3 ASP A 340
THR A 338
GLU A 327
 None
 0.85A 1pj7A-2ji4A:
2.2		 1pj7A-2ji4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 173
ARG A 202
ALA A 165
LEU A 169
ILE A 341
 None
None
CL  A1369 (-4.0A)
None
None
 0.99A 2h79A-2ji4A:
undetectable		 2h79A-2ji4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A  78
ILE A 108
THR A 144
LEU A 142
PHE A 156
 None
 1.20A 2jn3A-2ji4A:
undetectable		 2jn3A-2ji4A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A  22
GLY A  47
VAL A  49
ILE A  38
ALA A  39
 None
 1.10A 2yy8A-2ji4A:
undetectable
2yy8B-2ji4A:
2.9		 2yy8A-2ji4A:
18.06
2yy8B-2ji4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 173
ARG A 202
ALA A 165
LEU A 169
ILE A 341
 None
None
CL  A1369 (-4.0A)
None
None
 0.95A 3gwsX-2ji4A:
undetectable		 3gwsX-2ji4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 SER A 166
PHE A 168
ILE A 344
LEU A 163
SER A 198
 CL  A1369 (-3.8A)
None
None
None
None
 1.27A 3ko0A-2ji4A:
undetectable
3ko0B-2ji4A:
undetectable
3ko0C-2ji4A:
undetectable
3ko0D-2ji4A:
undetectable		 3ko0A-2ji4A:
14.12
3ko0B-2ji4A:
14.12
3ko0C-2ji4A:
14.12
3ko0D-2ji4A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 11 SER A 198
LEU A 163
SER A 166
PHE A 168
ILE A 344
 None
None
CL  A1369 (-3.8A)
None
None
 1.27A 3ko0A-2ji4A:
undetectable
3ko0B-2ji4A:
undetectable
3ko0I-2ji4A:
undetectable
3ko0J-2ji4A:
undetectable		 3ko0A-2ji4A:
14.12
3ko0B-2ji4A:
14.12
3ko0I-2ji4A:
14.12
3ko0J-2ji4A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 SER A 166
PHE A 168
ILE A 344
LEU A 163
SER A 198
 CL  A1369 (-3.8A)
None
None
None
None
 1.22A 3ko0M-2ji4A:
undetectable
3ko0N-2ji4A:
undetectable
3ko0O-2ji4A:
undetectable
3ko0P-2ji4A:
undetectable		 3ko0M-2ji4A:
14.12
3ko0N-2ji4A:
14.12
3ko0O-2ji4A:
14.12
3ko0P-2ji4A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A 340
ILE A  75
ILE A  38
SER A 346
PRO A 109
 None
 1.07A 3kpdC-2ji4A:
undetectable		 3kpdC-2ji4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 10 SER A 198
SER A 166
PHE A 168
ILE A 344
LEU A 163
 None
CL  A1369 (-3.8A)
None
None
None
 1.23A 3m0wC-2ji4A:
undetectable
3m0wD-2ji4A:
undetectable
3m0wE-2ji4A:
undetectable
3m0wF-2ji4A:
undetectable		 3m0wC-2ji4A:
15.34
3m0wD-2ji4A:
15.34
3m0wE-2ji4A:
15.34
3m0wF-2ji4A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 10 LEU A 163
SER A 166
PHE A 168
ILE A 344
SER A 198
 None
CL  A1369 (-3.8A)
None
None
None
 1.18A 3m0wE-2ji4A:
undetectable
3m0wF-2ji4A:
undetectable
3m0wG-2ji4A:
undetectable
3m0wH-2ji4A:
undetectable		 3m0wE-2ji4A:
15.34
3m0wF-2ji4A:
15.34
3m0wG-2ji4A:
15.34
3m0wH-2ji4A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		5 / 10 LEU A 163
SER A 166
PHE A 168
ILE A 344
SER A 198
 None
CL  A1369 (-3.8A)
None
None
None
 1.15A 3m0wA-2ji4A:
undetectable
3m0wB-2ji4A:
undetectable
3m0wI-2ji4A:
undetectable
3m0wJ-2ji4A:
undetectable		 3m0wA-2ji4A:
15.34
3m0wB-2ji4A:
15.34
3m0wI-2ji4A:
15.34
3m0wJ-2ji4A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 6 THR A 323
SER A 114
ILE A 152
THR A  77
 None
 1.08A 3q70A-2ji4A:
undetectable		 3q70A-2ji4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 4 PRO A 109
LEU A  34
ILE A  38
ARG A  41
 None
 1.30A 3w1wA-2ji4A:
3.2		 3w1wA-2ji4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		4 / 5 ASN A 322
ASP A 340
SER A 342
ARG A  41
 None
 1.31A 5w4zA-2ji4A:
undetectable		 5w4zA-2ji4A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens) 		3 / 3 VAL A 318
GLU A 317
ILE A 310
 None
 0.64A 6f7lB-2ji4A:
undetectable		 6f7lB-2ji4A:
22.96