SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.58A 1c9sI-2jifA:
undetectable
1c9sJ-2jifA:
undetectable		 1c9sI-2jifA:
10.55
1c9sJ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.59A 1c9sU-2jifA:
undetectable
1c9sV-2jifA:
undetectable		 1c9sU-2jifA:
10.55
1c9sV-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 LEU A 218
SER A 234
GLY A 280
PHE A 174
 None
 1.08A 1fapB-2jifA:
1.4		 1fapB-2jifA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.62A 1gtnA-2jifA:
undetectable
1gtnK-2jifA:
undetectable		 1gtnA-2jifA:
10.55
1gtnK-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.66A 1gtnA-2jifA:
undetectable
1gtnB-2jifA:
undetectable		 1gtnA-2jifA:
10.55
1gtnB-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.64A 1gtnC-2jifA:
undetectable
1gtnD-2jifA:
undetectable		 1gtnC-2jifA:
10.55
1gtnD-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.60A 1gtnD-2jifA:
undetectable
1gtnE-2jifA:
undetectable		 1gtnD-2jifA:
10.55
1gtnE-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.64A 1gtnE-2jifA:
undetectable
1gtnF-2jifA:
undetectable		 1gtnE-2jifA:
10.55
1gtnF-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.64A 1gtnF-2jifA:
undetectable
1gtnG-2jifA:
undetectable		 1gtnF-2jifA:
10.55
1gtnG-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.60A 1gtnI-2jifA:
undetectable
1gtnJ-2jifA:
undetectable		 1gtnI-2jifA:
10.55
1gtnJ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.61A 1gtnJ-2jifA:
undetectable
1gtnK-2jifA:
undetectable		 1gtnJ-2jifA:
10.55
1gtnK-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.64A 1gtnP-2jifA:
undetectable
1gtnQ-2jifA:
undetectable		 1gtnP-2jifA:
10.55
1gtnQ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 ILE A 409
THR A 411
LEU A 304
GLY A 379
GLU A 376
 None
 1.44A 1i7qA-2jifA:
undetectable		 1i7qA-2jifA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLU A 344
GLU A 126
ALA A 305
THR A 381
 None
 0.94A 1ie4B-2jifA:
undetectable
1ie4D-2jifA:
undetectable		 1ie4B-2jifA:
18.13
1ie4D-2jifA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLU A 127
GLN A  75
LYS A  70
VAL A  68
 None
 1.38A 1l2iB-2jifA:
undetectable		 1l2iB-2jifA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ALA A 298
GLY A 296
GLY A 293
ILE A 377
GLY A 379
 None
 0.96A 1sqfA-2jifA:
undetectable		 1sqfA-2jifA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.58A 1utdB-2jifA:
undetectable
1utdC-2jifA:
undetectable		 1utdB-2jifA:
10.55
1utdC-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.59A 1utdF-2jifA:
undetectable
1utdG-2jifA:
undetectable		 1utdF-2jifA:
10.55
1utdG-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.59A 1utdI-2jifA:
undetectable
1utdJ-2jifA:
undetectable		 1utdI-2jifA:
10.55
1utdJ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.57A 1utdJ-2jifA:
undetectable
1utdK-2jifA:
undetectable		 1utdJ-2jifA:
10.55
1utdK-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LEU A  97
PHE A  98
GLY A 101
THR A 114
 None
 1.00A 2bdmA-2jifA:
undetectable		 2bdmA-2jifA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ARG A 405
ASP A 132
SER A 134
SER A  87
 None
 1.04A 2j2pD-2jifA:
undetectable
2j2pF-2jifA:
undetectable		 2j2pD-2jifA:
20.78
2j2pF-2jifA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 THR A 121
ILE A 125
GLY A 296
LEU A 276
ASN A 143
 None
 1.02A 2y7hB-2jifA:
undetectable		 2y7hB-2jifA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 THR A 121
ILE A 125
GLY A 296
LEU A 276
ASN A 143
 None
 1.01A 2y7hC-2jifA:
undetectable		 2y7hC-2jifA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 8 LEU A 349
THR A 350
GLY A 303
ALA A 305
THR A 381
 None
 1.33A 3jusB-2jifA:
0.0		 3jusB-2jifA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 9 LEU A 349
THR A 350
GLY A 303
ALA A 305
THR A 381
 None
 1.33A 3jusB-2jifA:
undetectable		 3jusB-2jifA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 GLY A 104
ILE A 125
VAL A 124
 None
 0.50A 3nv6A-2jifA:
0.9		 3nv6A-2jifA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLN A 300
ILE A 297
SER A 210
SER A 209
 None
None
CL  A1437 ( 4.6A)
FAD  A1433 (-2.8A)
 1.34A 3pmzD-2jifA:
undetectable		 3pmzD-2jifA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 TYR A 372
LEU A 357
ARG A 294
 None
None
COS  A1434 (-3.3A)
 0.81A 3sufB-2jifA:
undetectable		 3sufB-2jifA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 CYH A 139
ILE A 141
GLN A 142
ILE A 105
 None
 1.13A 4w5qA-2jifA:
undetectable		 4w5qA-2jifA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 CYH A 139
ILE A 141
GLN A 142
ILE A 105
 None
 1.10A 4z4cA-2jifA:
undetectable		 4z4cA-2jifA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 TYR A 351
GLY A 303
GLU A 126
ASP A 310
 None
 1.33A 5emlA-2jifA:
undetectable		 5emlA-2jifA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ALA A 407
GLN A 380
THR A 382
 None
 0.76A 5n0oA-2jifA:
undetectable		 5n0oA-2jifA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 VAL A 400
LYS A 402
ILE A 386
LYS A 396
 None
 1.46A 5q1sA-2jifA:
undetectable		 5q1sA-2jifA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 GLU A 292
ASN A 291
GLY A 288
GLY A 296
PHE A 174
ILE A 295
 None
COS  A1434 (-3.0A)
None
None
None
None
 1.22A 5vooD-2jifA:
undetectable		 5vooD-2jifA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ASN A 291
GLY A 288
GLY A 296
PHE A 174
ILE A 295
 COS  A1434 (-3.0A)
None
None
None
None
 1.16A 5vooF-2jifA:
undetectable		 5vooF-2jifA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 ILE A 125
ALA A 374
TYR A 413
GLY A 410
ALA A 133
 None
 1.19A 6ieyA-2jifA:
undetectable
6ieyB-2jifA:
undetectable		 6ieyA-2jifA:
21.45
6ieyB-2jifA:
21.45