SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLU A 112
ILE A 111
ARG A 114
LEU A  58
ILE A  66
 None
 1.30A 1d1gA-2jigA:
undetectable		 1d1gA-2jigA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 ASP A 236
HIS A 135
HIS A 133
 ZN  A1253 (-2.2A)
ZN  A1253 (-3.0A)
None
 0.69A 1oe3A-2jigA:
undetectable		 1oe3A-2jigA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 HIS A 143
ASP A 145
THR A 164
HIS A 227
SER A 239
 ZN  A1252 ( 3.3A)
ZN  A1252 ( 2.4A)
None
ZN  A1252 ( 3.3A)
PD2  A1254 (-3.3A)
 0.60A 1uofA-2jigA:
8.3		 1uofA-2jigA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A  42
LEU A  54
PHE A  57
MET A 165
 None
 0.89A 1x8vA-2jigA:
undetectable		 1x8vA-2jigA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 ASP A 236
HIS A 135
HIS A 133
 ZN  A1253 (-2.2A)
ZN  A1253 (-3.0A)
None
 0.70A 2xxgA-2jigA:
undetectable		 2xxgA-2jigA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 10 LEU A 132
HIS A 143
ASP A 145
HIS A 227
TRP A 243
 None
ZN  A1252 ( 3.3A)
ZN  A1252 ( 2.4A)
ZN  A1252 ( 3.3A)
PD2  A1254 (-4.1A)
 0.95A 3kcxA-2jigA:
8.3		 3kcxA-2jigA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 10 TYR A 134
LEU A 132
HIS A 143
HIS A 227
TRP A 243
 PD2  A1254 (-4.5A)
None
ZN  A1252 ( 3.3A)
ZN  A1252 ( 3.3A)
PD2  A1254 (-4.1A)
 1.32A 3kcxA-2jigA:
8.3		 3kcxA-2jigA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		3 / 4 SER A  90
GLY A 228
GLU A 177
 None
PD2  A1254 (-3.8A)
None
 0.62A 3raeA-2jigA:
1.6
3raeC-2jigA:
undetectable		 3raeA-2jigA:
16.47
3raeC-2jigA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 129
THR A 119
ILE A  66
PHE A  57
LEU A  58
 None
 1.12A 3vw1B-2jigA:
undetectable		 3vw1B-2jigA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 137
HIS A 135
ASP A 236
HIS A 133
GLY A 235
 None
ZN  A1253 (-3.0A)
ZN  A1253 (-2.2A)
None
None
 1.29A 4bz6C-2jigA:
undetectable		 4bz6C-2jigA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 TYR A 134
HIS A 143
HIS A 227
TYR A 168
 PD2  A1254 (-4.5A)
ZN  A1252 ( 3.3A)
ZN  A1252 ( 3.3A)
None
 1.37A 4df2A-2jigA:
undetectable		 4df2A-2jigA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 7 LYS A  55
LEU A  53
LEU A 210
SER A 239
 None
None
None
PD2  A1254 (-3.3A)
 1.16A 4iklA-2jigA:
undetectable
4iklB-2jigA:
undetectable		 4iklA-2jigA:
19.64
4iklB-2jigA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		3 / 4 SER A  90
GLY A 228
GLU A 177
 None
PD2  A1254 (-3.8A)
None
 0.58A 4juoA-2jigA:
undetectable
4juoC-2jigA:
undetectable		 4juoA-2jigA:
16.47
4juoC-2jigA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		4 / 5 TYR A 134
ARG A  93
ASP A 149
GLU A 141
 PD2  A1254 (-4.5A)
GOL  A1255 (-4.3A)
None
None
 1.24A 4nkvB-2jigA:
undetectable		 4nkvB-2jigA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2jig PROLYL-4 HYDROXYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 212
SER A 214
VAL A 163
ARG A 161
GLY A 154
 None
 1.21A 5f9zB-2jigA:
undetectable		 5f9zB-2jigA:
19.37