SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 10 ALA A  88
LEU A  23
LEU A  94
VAL A  68
ILE A  27
 None
 1.12A 2w9hA-2jikA:
undetectable		 2w9hA-2jikA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  22
GLY A  24
ALA A  54
LEU A  55
ASN A  50
 None
 0.95A 2zulA-2jikA:
undetectable		 2zulA-2jikA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  88
LEU A  23
LEU A  94
VAL A  68
ILE A  27
 None
 1.13A 3datA-2jikA:
undetectable		 3datA-2jikA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  22
GLY A  24
ALA A  54
LEU A  55
ASN A  50
 None
 0.93A 3dmhA-2jikA:
undetectable		 3dmhA-2jikA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 10 ALA A  88
LEU A  23
LEU A  94
VAL A  68
ILE A  27
 None
 1.15A 3fl9E-2jikA:
undetectable		 3fl9E-2jikA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 11 ALA A  88
LEU A  23
LEU A  94
VAL A  68
ILE A  27
 None
 1.12A 3frbX-2jikA:
undetectable		 3frbX-2jikA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 9 ALA A  88
LEU A  23
LEU A  94
VAL A  68
ILE A  27
 None
 1.12A 3freX-2jikA:
undetectable		 3freX-2jikA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		5 / 11 ALA A  88
LEU A  23
LEU A  94
VAL A  68
ILE A  27
 None
 1.26A 3jw5A-2jikA:
undetectable		 3jw5A-2jikA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2jik SYNAPTOJANIN-2
BINDING PROTEIN
(Homo
sapiens) 		3 / 3 SER A  45
PHE A  25
LYS A  48
 None
 0.97A 3u88A-2jikA:
undetectable		 3u88A-2jikA:
10.87