SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 LEU A 316
GLY A 152
VAL A 272
LEU A 132
PHE A 148
 None
PLP  A1494 (-3.5A)
None
None
None
 1.17A 1gs4A-2jisA:
undetectable		 1gs4A-2jisA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 GLU A 402
LEU A 403
VAL A 392
LEU A 483
 None
 0.94A 1hk3A-2jisA:
undetectable		 1hk3A-2jisA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 PHE A 465
LEU A 486
LEU A 482
 None
 0.68A 1mx1E-2jisA:
undetectable		 1mx1E-2jisA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 5 GLU A 128
LEU A 132
ASP A 145
LEU A 325
 None
 1.11A 1n13B-2jisA:
undetectable
1n13C-2jisA:
undetectable		 1n13B-2jisA:
10.76
1n13C-2jisA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 4 LEU A 282
VAL A 280
ILE A 381
TRP A 369
 None
 1.38A 1s9qB-2jisA:
undetectable		 1s9qB-2jisA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.83A 1usqB-2jisA:
undetectable		 1usqB-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.84A 1usqC-2jisA:
undetectable		 1usqC-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.83A 1usqD-2jisA:
undetectable		 1usqD-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.84A 1usqE-2jisA:
undetectable		 1usqE-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.84A 1usqF-2jisA:
undetectable		 1usqF-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZWP_A_NIMA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 5 LEU A  93
GLY A 246
ASP A 273
LYS A 305
 None
None
PLP  A1494 (-2.7A)
PLP  A1494 (-1.4A)
 1.49A 1zwpA-2jisA:
0.0		 1zwpA-2jisA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 ALA A 300
GLY A 151
SER A 193
 None
PLP  A1494 (-3.5A)
PLP  A1494 ( 4.1A)
 0.59A 2ivuA-2jisA:
undetectable		 2ivuA-2jisA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.84A 2jkjA-2jisA:
undetectable		 2jkjA-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.83A 2jkjB-2jisA:
undetectable		 2jkjB-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.83A 2jkjC-2jisA:
undetectable		 2jkjC-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.84A 2jkjE-2jisA:
undetectable		 2jkjE-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.79A 2jklA-2jisA:
undetectable		 2jklA-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.79A 2jklB-2jisA:
undetectable		 2jklB-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.80A 2jklC-2jisA:
undetectable		 2jklC-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.80A 2jklD-2jisA:
undetectable		 2jklD-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.80A 2jklE-2jisA:
undetectable		 2jklE-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PRO A  87
GLY A  85
ILE A  33
GLY A  36
 None
 0.80A 2jklF-2jisA:
undetectable		 2jklF-2jisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 GLY A 246
VAL A 280
SER A 245
LEU A 290
 None
 0.82A 2oa1B-2jisA:
undetectable		 2oa1B-2jisA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 THR A 244
ASP A 254
SER A 187
TYR A 192
 PLP  A1494 ( 4.5A)
None
None
None
 1.36A 2xz5A-2jisA:
undetectable
2xz5C-2jisA:
undetectable		 2xz5A-2jisA:
17.67
2xz5C-2jisA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 ARG A 327
TYR A 165
ASP A 297
GLN A 319
 None
 1.44A 3dh0A-2jisA:
undetectable		 3dh0A-2jisA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 SER A 472
ASP A 382
ASP A  98
TRP A 369
 None
 1.18A 3havA-2jisA:
undetectable		 3havA-2jisA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLU A 128
ARG A 358
ALA A 346
GLU A 129
ARG A 136
 None
 1.43A 3k37B-2jisA:
undetectable		 3k37B-2jisA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLU A 128
ARG A 358
ALA A 346
GLU A 129
ARG A 136
 None
 1.49A 3k39D-2jisA:
undetectable		 3k39D-2jisA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLU A 128
ARG A 358
ALA A 346
GLU A 129
ARG A 136
 None
 1.49A 3k39N-2jisA:
undetectable		 3k39N-2jisA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ALA A  32
ILE A 106
LEU A  21
ARG A  22
VAL A  24
 None
 1.09A 3o7wA-2jisA:
undetectable		 3o7wA-2jisA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 9 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.47A 3ozkA-2jisA:
undetectable		 3ozkA-2jisA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 PHE A 465
PHE A 416
PRO A 418
GLN A 491
MET A 445
 None
 1.29A 4a84A-2jisA:
undetectable		 4a84A-2jisA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ALA A 275
ASN A 302
ILE A 293
VAL A 272
HIS A 271
 PLP  A1494 (-3.5A)
PLP  A1494 (-3.5A)
None
None
None
 1.29A 4azsA-2jisA:
2.6		 4azsA-2jisA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 THR A 113
LEU A 111
VAL A 360
GLN A 115
 None
 0.86A 4em2A-2jisA:
0.0		 4em2A-2jisA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 6 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.47A 4ikiB-2jisA:
undetectable		 4ikiB-2jisA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 7 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.45A 4ikjA-2jisA:
undetectable
4ikjB-2jisA:
undetectable		 4ikjA-2jisA:
12.97
4ikjB-2jisA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 8 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.45A 4ikjA-2jisA:
undetectable
4ikjB-2jisA:
undetectable		 4ikjA-2jisA:
12.97
4ikjB-2jisA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 8 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.45A 4ikkA-2jisA:
undetectable
4ikkB-2jisA:
undetectable		 4ikkA-2jisA:
12.97
4ikkB-2jisA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 7 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.43A 4ikkA-2jisA:
undetectable
4ikkB-2jisA:
undetectable		 4ikkA-2jisA:
12.97
4ikkB-2jisA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ASP A 273
LEU A 162
GLY A 152
ASN A 302
ALA A 159
 PLP  A1494 (-2.7A)
None
PLP  A1494 (-3.5A)
PLP  A1494 (-3.5A)
None
 1.20A 4n09A-2jisA:
3.9		 4n09A-2jisA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 4 ASN A 156
SER A 314
ALA A 300
VAL A 299
 PLP  A1494 ( 4.7A)
PLP  A1494 ( 4.9A)
None
None
 0.98A 4x1kC-2jisA:
3.0		 4x1kC-2jisA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 ASP A 478
VAL A 469
LEU A 391
 None
 0.53A 5e5jB-2jisA:
undetectable		 5e5jB-2jisA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 GLY A 454
GLN A 456
LYS A 442
 None
 0.89A 5imsB-2jisA:
3.7		 5imsB-2jisA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 4 ASN A 156
SER A 314
ALA A 300
VAL A 299
 PLP  A1494 ( 4.7A)
PLP  A1494 ( 4.9A)
None
None
 1.03A 5nm5A-2jisA:
3.0		 5nm5A-2jisA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 VAL A  27
VAL A  24
GLN A  67
 None
 0.72A 5qhgA-2jisA:
undetectable		 5qhgA-2jisA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 GLU A  45
ARG A  79
TYR A  80
 None
 0.50A 5trqB-2jisA:
undetectable		 5trqB-2jisA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 LEU A 377
GLN A 372
LYS A 134
 None
 0.94A 6exiB-2jisA:
undetectable		 6exiB-2jisA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 LEU A 377
GLN A 372
LYS A 134
 None
 0.92A 6exiA-2jisA:
undetectable		 6exiA-2jisA:
9.94