SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 6 ILE A 114
LYS A  47
ALA A  40
VAL A  66
 None
 0.99A 1hk1A-2jj4A:
undetectable		 1hk1A-2jj4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 7 ARG A 139
GLU A 179
ALA A 176
ALA A 177
 None
 0.98A 2ejfA-2jj4A:
undetectable		 2ejfA-2jj4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		5 / 11 VAL A 110
VAL A 102
ARG A 109
ILE A  74
ALA A 188
 None
None
None
NLG  A1292 (-4.8A)
NLG  A1292 (-3.3A)
 1.14A 2zbzA-2jj4A:
undetectable		 2zbzA-2jj4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 7 THR A  98
VAL A 101
ILE A  74
THR A  94
 None
None
NLG  A1292 (-4.8A)
None
 0.88A 3deuA-2jj4A:
undetectable		 3deuA-2jj4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		5 / 11 SER A 174
ILE A 186
VAL A 136
VAL A 152
ILE A 195
 NLG  A1292 (-3.2A)
None
None
None
None
 1.17A 3rf4A-2jj4A:
undetectable
3rf4C-2jj4A:
undetectable		 3rf4A-2jj4A:
17.76
3rf4C-2jj4A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		5 / 11 ILE A 195
SER A 174
ILE A 186
VAL A 136
VAL A 152
 None
NLG  A1292 (-3.2A)
None
None
None
 1.18A 3rf4B-2jj4A:
undetectable
3rf4C-2jj4A:
undetectable		 3rf4B-2jj4A:
17.76
3rf4C-2jj4A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		3 / 3 ASP A  97
VAL A 101
LEU A  78
 None
 0.66A 5e5jB-2jj4A:
undetectable		 5e5jB-2jj4A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 4 LEU A 235
ILE A 236
PRO A 230
LEU A 227
 None
 1.16A 5eb3A-2jj4A:
undetectable		 5eb3A-2jj4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		5 / 12 GLY A  29
LEU A 274
ILE A 270
PHE A 279
THR A  31
 None
 1.10A 5eskA-2jj4A:
undetectable		 5eskA-2jj4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 6 GLY A 130
THR A 131
SER A 173
VAL A 175
 None
 0.98A 5ewuB-2jj4A:
undetectable		 5ewuB-2jj4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 8 VAL A 126
GLY A 133
LEU A 135
THR A 131
 None
 1.06A 5sxqB-2jj4A:
undetectable		 5sxqB-2jj4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2jj4 ACETYLGLUTAMATE
KINASE
(Synechococcus
elongatus) 		4 / 8 VAL A 126
GLY A 133
LEU A 135
THR A 131
 None
 1.06A 5syjA-2jj4A:
undetectable		 5syjA-2jj4A:
18.27