SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jjd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		4 / 8 VAL A 363
THR A 344
TYR A 388
LEU A 391
 None
 0.97A 1z2bB-2jjdA:
undetectable		 1z2bB-2jjdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		3 / 3 ASN A 163
ASN A 191
ARG A 374
 None
 0.67A 2rlcA-2jjdA:
undetectable		 2rlcA-2jjdA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		4 / 5 VAL A 686
TYR A 683
VAL A 658
ASP A 657
 None
 1.31A 2x45C-2jjdA:
undetectable		 2x45C-2jjdA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		3 / 3 ARG A 467
ASP A 509
ASN A 451
 None
 0.76A 2zzmA-2jjdA:
undetectable		 2zzmA-2jjdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 ASN A 451
GLY A 446
VAL A 468
ARG A 669
LEU A 470
 None
 1.24A 3mnoA-2jjdA:
undetectable		 3mnoA-2jjdA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 ASN A 451
GLY A 446
VAL A 468
ARG A 669
LEU A 470
 None
 1.25A 3mnpA-2jjdA:
undetectable		 3mnpA-2jjdA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 LEU A 296
VAL A 333
ILE A 346
THR A 229
VAL A 231
 None
 0.81A 3so9B-2jjdA:
undetectable		 3so9B-2jjdA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 HIS A 591
GLU A 530
VAL A 528
THR A 639
GLY A 638
 None
 1.02A 4hvcA-2jjdA:
undetectable		 4hvcA-2jjdA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 VAL A 333
ALA A 206
PHE A 316
PHE A 345
GLY A 343
 None
 1.21A 4mm6A-2jjdA:
undetectable		 4mm6A-2jjdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		4 / 6 ALA A 498
GLY A 635
ILE A 487
VAL A 662
 None
 0.77A 4r21A-2jjdA:
undetectable		 4r21A-2jjdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 9 ALA A 498
GLY A 635
ALA A 634
ILE A 487
VAL A 662
 None
 1.04A 4r21B-2jjdA:
2.2		 4r21B-2jjdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		3 / 3 ARG A 567
ASP A 568
ARG A 588
 None
 0.66A 4wq4B-2jjdA:
undetectable		 4wq4B-2jjdA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 ILE A 230
GLU A 264
ARG A 291
ALA A 328
ILE A 259
 None
 1.15A 5igvA-2jjdA:
2.0		 5igvA-2jjdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		5 / 12 ILE A 230
GLU A 264
ARG A 291
ALA A 328
ILE A 259
 None
 1.21A 5ih0A-2jjdA:
1.9		 5ih0A-2jjdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		4 / 5 ARG A 567
GLN A 538
PRO A 541
ILE A 555
 None
 1.49A 5ki6A-2jjdA:
2.3		 5ki6A-2jjdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens) 		4 / 7 VAL A 267
ARG A 649
TYR A 490
GLU A 653
 None
 1.07A 5umwB-2jjdA:
1.5
5umwE-2jjdA:
undetectable		 5umwB-2jjdA:
8.89
5umwE-2jjdA:
8.89