SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2jjf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 435
LEU A 364
TYR A 363
LEU A  57
THR A  61
 None
 1.48A 1mxfC-2jjfA:
3.8		 1mxfC-2jjfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 ASN A  71
VAL A  76
LEU A  37
ALA A  50
VAL A  48
 None
 1.17A 1rv7A-2jjfA:
undetectable
1rv7B-2jjfA:
undetectable		 1rv7A-2jjfA:
13.24
1rv7B-2jjfA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 168
TYR A 286
ALA A 131
MET A 308
GLY A 310
 None
 1.28A 1uhoA-2jjfA:
undetectable		 1uhoA-2jjfA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 183
THR A 185
PRO A 182
 None
 0.86A 1unjW-2jjfA:
undetectable		 1unjW-2jjfA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 183
THR A 185
PRO A 182
 None
 0.85A 1unmE-2jjfA:
undetectable		 1unmE-2jjfA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 114
ALA A 285
GLN A 288
LEU A 427
THR A 302
 None
 1.38A 1ya3B-2jjfA:
undetectable		 1ya3B-2jjfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 232
ALA A 233
ALA A 266
ALA A 139
ILE A 196
 None
 1.18A 2aclC-2jjfA:
undetectable		 2aclC-2jjfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  47
ILE A 412
LEU A 414
ARG A 422
 None
 0.98A 2byoA-2jjfA:
undetectable		 2byoA-2jjfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  41
THR A  40
LEU A  37
ALA A  50
 None
 1.42A 2e1qD-2jjfA:
undetectable		 2e1qD-2jjfA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 332
ASP A 337
GLY A 306
VAL A 307
VAL A 107
 None
 0.89A 2f8gA-2jjfA:
undetectable		 2f8gA-2jjfA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 437
THR A  61
VAL A 411
VAL A 429
LEU A 279
 None
 1.11A 2g78A-2jjfA:
undetectable		 2g78A-2jjfA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 390
GLY A 384
THR A 420
GLY A 204
LEU A 205
 None
 1.02A 2hw2A-2jjfA:
undetectable		 2hw2A-2jjfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 114
ALA A 285
GLN A 288
LEU A 427
THR A 302
 None
 1.44A 2oaxC-2jjfA:
undetectable		 2oaxC-2jjfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 218
PRO A 199
LEU A 163
ALA A 237
PHE A 235
 None
 1.42A 2vcvF-2jjfA:
undetectable		 2vcvF-2jjfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 157
ASP A 265
TRP A 142
ARG A 312
 None
 1.16A 3aruA-2jjfA:
2.8		 3aruA-2jjfA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 256
LEU A 218
ILE A 196
LEU A 163
PHE A 235
 None
 0.96A 3fl9E-2jjfA:
undetectable		 3fl9E-2jjfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 256
LEU A 218
ILE A 196
LEU A 163
PHE A 235
 None
 0.94A 3fl9F-2jjfA:
undetectable		 3fl9F-2jjfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 315
ASP A 294
ASP A 265
 None
 0.69A 3jb2A-2jjfA:
undetectable		 3jb2A-2jjfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 TYR A 173
LEU A 177
THR A 174
GLY A 128
ALA A 131
 None
 1.20A 3jusB-2jjfA:
0.5		 3jusB-2jjfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 173
LEU A 177
THR A 174
GLY A 128
ALA A 131
 None
 1.20A 3jusB-2jjfA:
undetectable		 3jusB-2jjfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 162
PHE A 249
PHE A 253
 None
 0.77A 3lk0D-2jjfA:
undetectable		 3lk0D-2jjfA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 162
PHE A 254
PHE A 253
 None
 0.65A 3lk0D-2jjfA:
undetectable		 3lk0D-2jjfA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 332
ASP A 337
GLY A 306
VAL A 307
VAL A 107
 None
 0.96A 3oxwA-2jjfA:
undetectable		 3oxwA-2jjfA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 404
ALA A 444
VAL A 448
GLU A 401
VAL A 378
 None
 1.19A 4da7A-2jjfA:
undetectable		 4da7A-2jjfA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 335
LYS A  92
PRO A  93
GLU A 126
 None
 0.93A 4z4fA-2jjfA:
2.8		 4z4fA-2jjfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 335
LYS A  92
PRO A  93
GLU A 126
 None
 0.95A 4z4gA-2jjfA:
undetectable		 4z4gA-2jjfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 402
ALA A 444
LEU A 406
ALA A 440
 None
 0.64A 4z90F-2jjfA:
undetectable
4z90G-2jjfA:
undetectable
4z90H-2jjfA:
undetectable
4z90J-2jjfA:
undetectable		 4z90F-2jjfA:
21.41
4z90G-2jjfA:
21.41
4z90H-2jjfA:
21.41
4z90J-2jjfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 335
LYS A  92
PRO A  93
GLU A 126
 None
 0.88A 5t7bA-2jjfA:
undetectable		 5t7bA-2jjfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 273
GLY A 276
ALA A 285
GLU A 133
VAL A 236
 None
 1.00A 6bqgA-2jjfA:
undetectable		 6bqgA-2jjfA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2jjf L-LYSINE EPSILON
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 426
GLY A 278
GLY A 361
GLY A 386
GLN A 288
 None
 1.04A 6nj9K-2jjfA:
undetectable		 6nj9K-2jjfA:
21.40